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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gwf FAD Cyclohexanone monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gwf FADCyclohexanone monooxygenase / 1.399
1w4x FADPhenylacetone monooxygenase 1.14.13.92 1.015
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.998
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.984
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.958
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.928
3gwd FADCyclohexanone monooxygenase / 0.896
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.861
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.833
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.814
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.812
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.811
2yg4 FADPutrescine oxidase / 0.809
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.807
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.800
2xvf FADPutative flavin-containing monooxygenase / 0.798
2zbw FADFerredoxin--NADP reductase / 0.798
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.793
4ap3 FADSteroid monooxygenase / 0.793
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.792
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.785
3pl8 FADPyranose 2-oxidase / 0.782
4ap1 FADSteroid monooxygenase / 0.782
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.781
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.781
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.780
3k4c FADPyranose 2-oxidase / 0.779
4opc FDAConserved Archaeal protein / 0.766
3he3 FADUDP-galactopyranose mutase / 0.764
2yg6 FADPutrescine oxidase / 0.762
4mih FADPyranose 2-oxidase 1.1.3.10 0.762
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.761
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.760
4em3 FADCoenzyme A disulfide reductase / 0.758
1yqz FADCoenzyme A disulfide reductase / 0.757
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.757
3kkj FADRenalase / 0.756
4mok FADPyranose 2-oxidase / 0.755
3qj4 FADRenalase / 0.754
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.753
4ntd FADThioredoxin reductase / 0.752
2gvc FADThiol-specific monooxygenase 1.14.13 0.751
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.751
2q7v FADThioredoxin reductase / 0.749
4em4 FADCoenzyme A disulfide reductase / 0.749
2ign FADPyranose 2-oxidase / 0.748
3atq FDAConserved Archaeal protein / 0.748
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.745
3ict FADCoenzyme A disulfide reductase / 0.745
2yg3 FADPutrescine oxidase / 0.744
4j33 FADKynurenine 3-monooxygenase / 0.742
1jnz FADAdenylylsulfate reductase, subunit A (AprA) / 0.741
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.741
1joa FADNADH peroxidase 1.11.1.1 0.740
2yg5 FADPutrescine oxidase / 0.739
3mj4 FADUDP-galactopyranose mutase / 0.738
4eqs FADCoenzyme A disulfide reductase / 0.738
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.736
4aos FADSteroid monooxygenase / 0.735
4eqw FADCoenzyme A disulfide reductase / 0.734
4eqr FADCoenzyme A disulfide reductase / 0.733
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.733
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.732
4fwf FADLysine-specific histone demethylase 1B 1 0.731
3fbs FADOxidoreductase / 0.730
4cnk FADL-amino acid oxidase / 0.730
2yqu FADDihydrolipoyl dehydrogenase / 0.729
4eqx FADCoenzyme A disulfide reductase / 0.729
3f8d FADNADH oxidase/thioredoxin reductase / 0.728
4j34 FADKynurenine 3-monooxygenase / 0.728
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.727
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.727
2fja FADAdenylylsulfate reductase, subunit A (AprA) / 0.726
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.725
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.722
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.721
2xve FADPutative flavin-containing monooxygenase / 0.721
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.718
4gus FADLysine-specific histone demethylase 1B 1 0.717
2yg7 FADPutrescine oxidase / 0.716
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.714
2xls FADPutative flavin-containing monooxygenase / 0.712
1nhr FADNADH peroxidase 1.11.1.1 0.711
3f8p NADNADH oxidase/thioredoxin reductase / 0.711
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.710
4hb9 FADUncharacterized protein / 0.710
3f8r NAPNADH oxidase/thioredoxin reductase / 0.709
2gv8 FADThiol-specific monooxygenase 1.14.13 0.708
2bi8 FADUDP-galactopyranose mutase 5.4.99.9 0.707
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.707
3lsm SFDPyranose 2-oxidase / 0.706
3rha FDAPutrescine oxidase / 0.706
3bg7 FADPyranose 2-oxidase / 0.705
2bi7 FADUDP-galactopyranose mutase 5.4.99.9 0.704
4hsu FADLysine-specific histone demethylase 1B 1 0.704
1z6l FADPolyamine oxidase FMS1 / 0.703
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.703
1ryi FADGlycine oxidase 1.4.3.19 0.702
4guu FA9Lysine-specific histone demethylase 1B 1 0.702
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.701
3ada NADSubunit alpha of sarocosine oxidase / 0.701
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.701
4tlz FADKtzI / 0.701
2bab FADPutative aminooxidase / 0.700
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.700
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.700
4emw FADCoenzyme A disulfide reductase / 0.700
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.700
1h83 FADPolyamine oxidase 1.5.3.14 0.698
4opg FDAConserved Archaeal protein / 0.698
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.696
1trb FADThioredoxin reductase 1.8.1.9 0.696
3kyb FADUDP-galactopyranose mutase 5.4.99.9 0.696
4opd FDAConserved Archaeal protein / 0.696
1ger FADGlutathione reductase 1.8.1.7 0.695
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.695
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.695
1f8w FADNADH peroxidase 1.11.1.1 0.694
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.694
4cnj FADL-amino acid oxidase / 0.692
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.691
4nzh FADL-ornithine N(5)-monooxygenase / 0.691
1tdf FADThioredoxin reductase 1.8.1.9 0.690
4gcm FADThioredoxin reductase 1.8.1.9 0.690
3vqr FADPutative oxidoreductase / 0.689
4rsl FADFructosyl peptide oxidase / 0.688
3k7t FAD6-hydroxy-L-nicotine oxidase / 0.687
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.686
3nlc FADUncharacterized protein / 0.686
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.685
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.685
5cku FADL-ornithine N(5)-monooxygenase / 0.685
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.685
3axb FADPutative oxidoreductase / 0.684
1get FADGlutathione reductase 1.8.1.7 0.683
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.683
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.682
3ish FADThioredoxin reductase 1.8.1.9 0.681
4b63 FADL-ornithine N(5)-monooxygenase / 0.681
4j57 FADThioredoxin reductase 2 1.8.1.9 0.681
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.680
2iw5 FADLysine-specific histone demethylase 1A 1 0.680
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.680
4yac NAIC alpha-dehydrogenase / 0.680
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.679
3ad9 NADSubunit alpha of sarocosine oxidase / 0.679
4b69 FADL-ornithine N(5)-monooxygenase / 0.678
4xbf FADLysine-specific histone demethylase 1A 1 0.678
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.677
1nhp FADNADH peroxidase 1.11.1.1 0.676
2vq7 FADPutative flavin-containing monooxygenase / 0.676
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.676
4qi7 FADCellobiose dehydrogenase / 0.676
1knp FADL-aspartate oxidase 1.4.3.16 0.675
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.675
2rgo FADAlpha-Glycerophosphate Oxidase / 0.675
2y48 FADLysine-specific histone demethylase 1A 1 0.674
3cgd FADCoenzyme A disulfide reductase / 0.674
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.674
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.674
4gut FADLysine-specific histone demethylase 1B 1 0.674
5j60 FADThioredoxin reductase / 0.674
3sz0 FADSulfide-quinone reductase / 0.673
4j36 FADKynurenine 3-monooxygenase / 0.673
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.672
2iid FADL-amino-acid oxidase 1.4.3.2 0.672
1nhq FADNADH peroxidase 1.11.1.1 0.671
2rab FADGlutathione amide reductase / 0.671
2xlp FADPutative flavin-containing monooxygenase / 0.671
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.671
1fec FADTrypanothione reductase 1.8.1.12 0.670
2gqw FADFerredoxin reductase / 0.670
3k30 ADPHistamine dehydrogenase / 0.670
3lsi FADPyranose 2-oxidase / 0.670
3t2z FADSulfide-quinone reductase / 0.670
1c0l FADD-amino-acid oxidase 1.4.3.3 0.669
2hqm FADGlutathione reductase 1.8.1.7 0.669
4jq9 FADDihydrolipoyl dehydrogenase / 0.669
2eq9 FADDihydrolipoyl dehydrogenase / 0.667
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.667
4opi FDAConserved Archaeal protein / 0.667
4tlx FDAKtzI / 0.667
4mo2 FADUDP-galactopyranose mutase / 0.666
4rpg FADUDP-galactopyranose mutase 5.4.99.9 0.666
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.665
1nhs FADNADH peroxidase 1.11.1.1 0.665
1qo8 FADFumarate reductase flavoprotein subunit / 0.665
2xlr FADPutative flavin-containing monooxygenase / 0.665
3ics FADCoenzyme A disulfide reductase / 0.665
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.665
2b9y FADPutative aminooxidase / 0.664
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.664
4utl FNRXenobiotic reductase / 0.664
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.663
2rgj FADFlavin-containing monooxygenase / 0.663
3cty FADProbable thioredoxin reductase / 0.663
4gur FADLysine-specific histone demethylase 1B 1 0.663
4tm4 FDAKtzI / 0.663
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.663
2b9x FADPutative aminooxidase / 0.662
2bac FADPutative aminooxidase / 0.662
2q0l FADThioredoxin reductase 1.8.1.9 0.662
4fwj FADLysine-specific histone demethylase 1B 1 0.662
1ges FADGlutathione reductase 1.8.1.7 0.661
2igo FADPyranose 2-oxidase / 0.661
4dna FADProbable glutathione reductase / 0.661
1pdh FASp-hydroxybenzoate hydroxylase / 0.660
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.660
2r0c FADPutative FAD-monooxygenase / 0.660
2vqb FADPutative flavin-containing monooxygenase / 0.660
2vvl FADMonoamine oxidase N 1.4.3.4 0.660
3cn8 FADPolyamine oxidase FMS1 / 0.660
3hdy FADUDP-galactopyranose mutase / 0.660
1tde FADThioredoxin reductase 1.8.1.9 0.659
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.658
2q0k FADThioredoxin reductase 1.8.1.9 0.658
2xvh FADPutative flavin-containing monooxygenase / 0.658
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.657
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.657
3s5w FADL-ornithine N(5)-monooxygenase / 0.657
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.657
1h81 FADPolyamine oxidase 1.5.3.14 0.656
1ijh FADCholesterol oxidase 1.1.3.6 0.656
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.656
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.656
1bzl FADTrypanothione reductase 1.8.1.12 0.655
2jae FADL-amino acid oxidase / 0.655
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.654
1tyt FADTrypanothione reductase 1.8.1.12 0.654
2gr3 FADFerredoxin reductase / 0.654
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.654
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.653
1gxf FADTrypanothione reductase 1.8.1.12 0.653
2ywl FADThioredoxin reductase related protein / 0.653
3v76 FDAUncharacterized protein / 0.653
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.652
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.652
4fwe FADLysine-specific histone demethylase 1B 1 0.652
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.652
1f3p FADFerredoxin reductase / 0.651
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.651
1q1w FADPutidaredoxin reductase 1.18.1.5 0.651
3ihg FADAklavinone 12-hydroxylase RdmE / 0.651
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.651
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.650
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
4aox FADSteroid monooxygenase / 0.650
4b65 FADL-ornithine N(5)-monooxygenase / 0.650