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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gwd FAD Cyclohexanone monooxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gwd FADCyclohexanone monooxygenase / 1.410
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.077
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.072
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 1.069
4d04 FADPhenylacetone monooxygenase 1.14.13.92 1.058
4d03 FADPhenylacetone monooxygenase 1.14.13.92 1.006
2ylr FADPhenylacetone monooxygenase 1.14.13.92 1.004
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.989
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.950
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.937
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.937
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.925
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.924
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.923
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.916
3gwf FADCyclohexanone monooxygenase / 0.896
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.887
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.863
2gv8 FADThiol-specific monooxygenase 1.14.13 0.831
4em4 FADCoenzyme A disulfide reductase / 0.782
1y56 ATPUncharacterized protein / 0.772
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.762
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.759
4em3 FADCoenzyme A disulfide reductase / 0.759
2gvc FADThiol-specific monooxygenase 1.14.13 0.758
2xve FADPutative flavin-containing monooxygenase / 0.754
4ap3 FADSteroid monooxygenase / 0.749
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.747
1zk7 FADMercuric reductase 1.16.1.1 0.744
2ign FADPyranose 2-oxidase / 0.744
4eqx FADCoenzyme A disulfide reductase / 0.742
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.740
4emw FADCoenzyme A disulfide reductase / 0.739
4eqr FADCoenzyme A disulfide reductase / 0.738
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.736
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.735
4gcm FADThioredoxin reductase 1.8.1.9 0.732
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.731
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.731
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
3ict FADCoenzyme A disulfide reductase / 0.727
4aos FADSteroid monooxygenase / 0.725
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.725
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.723
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.721
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.721
3kkj FADRenalase / 0.721
2xvh FADPutative flavin-containing monooxygenase / 0.720
3k4c FADPyranose 2-oxidase / 0.719
3hdy FADUDP-galactopyranose mutase / 0.718
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.717
2xlp FADPutative flavin-containing monooxygenase / 0.717
1f3p FADFerredoxin reductase / 0.716
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.716
3he3 FADUDP-galactopyranose mutase / 0.715
3cty FADProbable thioredoxin reductase / 0.713
3mj4 FADUDP-galactopyranose mutase / 0.713
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.713
4b69 FADL-ornithine N(5)-monooxygenase / 0.713
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.713
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.712
4aox FADSteroid monooxygenase / 0.712
3lad FADDihydrolipoyl dehydrogenase / 0.711
4tm3 FADKtzI / 0.711
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.709
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.708
2vq7 FADPutative flavin-containing monooxygenase / 0.707
3f8p NADNADH oxidase/thioredoxin reductase / 0.707
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.706
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.706
3ad9 FADSubunit beta of sarcosine oxidase / 0.705
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.704
2xvf FADPutative flavin-containing monooxygenase / 0.704
3lsm SFDPyranose 2-oxidase / 0.704
3nlc FADUncharacterized protein / 0.704
4u2l SFDCholesterol oxidase 1.1.3.6 0.704
2xls FADPutative flavin-containing monooxygenase / 0.703
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.703
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.702
2yg7 FADPutrescine oxidase / 0.699
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.699
3t2y FADSulfide-quinone reductase / 0.699
1ges FADGlutathione reductase 1.8.1.7 0.697
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.696
3we0 FADLysine 2-monooxygenase / 0.696
5br7 FADUDP-galactopyranose mutase / 0.695
2q7v FADThioredoxin reductase / 0.694
4xbf FADLysine-specific histone demethylase 1A 1 0.694
1get FADGlutathione reductase 1.8.1.7 0.693
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.693
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.692
4qi7 FADCellobiose dehydrogenase / 0.692
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.692
3t14 FADSulfide-quinone reductase / 0.691
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.690
2gew FADCholesterol oxidase 1.1.3.6 0.690
3lsh FADPyranose 2-oxidase / 0.690
3t2k FADSulfide-quinone reductase / 0.690
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.690
4mih FADPyranose 2-oxidase 1.1.3.10 0.690
4u8m FDAUDP-galactopyranose mutase / 0.690
1n4u FAECholesterol oxidase 1.1.3.6 0.689
4u2s FDACholesterol oxidase 1.1.3.6 0.689
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.688
2cvj FADThioredoxin reductase related protein / 0.688
4gdd FADUDP-galactopyranose mutase / 0.688
4rek FADCholesterol oxidase 1.1.3.6 0.688
4u2t FADCholesterol oxidase 1.1.3.6 0.686
2e1m FADL-glutamate oxidase / 0.685
2hqm FADGlutathione reductase 1.8.1.7 0.685
2xlr FADPutative flavin-containing monooxygenase / 0.685
2yg4 FADPutrescine oxidase / 0.685
3gyj FADCholesterol oxidase 1.1.3.6 0.685
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.685
4ap1 FADSteroid monooxygenase / 0.683
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.682
2eq6 FADDihydrolipoyl dehydrogenase / 0.682
3b6d FAECholesterol oxidase 1.1.3.6 0.682
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.681
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.681
2r0c FADPutative FAD-monooxygenase / 0.681
4qi5 FADCellobiose dehydrogenase / 0.681
4yac NAIC alpha-dehydrogenase / 0.681
1e1n FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.680
1mxt FAECholesterol oxidase 1.1.3.6 0.680
4nte FADDepH / 0.680
1h83 FADPolyamine oxidase 1.5.3.14 0.679
1n1p FADCholesterol oxidase 1.1.3.6 0.679
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.679
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.679
3kpk FADSulfide-quinone reductase / 0.679
2vqb FADPutative flavin-containing monooxygenase / 0.678
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.678
4fwf FADLysine-specific histone demethylase 1B 1 0.678
4tlx FDAKtzI / 0.677
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.676
1zx9 FADMercuric reductase 1.16.1.1 0.676
2gqw FADFerredoxin reductase / 0.676
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.676
3syi FADSulfide-quinone reductase / 0.676
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.675
3lsi FADPyranose 2-oxidase / 0.675
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.674
1pdh FASp-hydroxybenzoate hydroxylase / 0.674
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.674
5i39 FADL-amino acid deaminase / 0.674
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.673
2eq9 FADDihydrolipoyl dehydrogenase / 0.673
2iw5 FADLysine-specific histone demethylase 1A 1 0.673
3ics FADCoenzyme A disulfide reductase / 0.673
4b1b FADThioredoxin reductase 1.8.1.9 0.673
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.673
4xwr FADCholesterol oxidase 1.1.3.6 0.673
3gyi FADCholesterol oxidase 1.1.3.6 0.672
3icr FADCoenzyme A disulfide reductase / 0.672
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.671
3t37 FADPyridoxine 4-oxidase / 0.670
1cf3 FADGlucose oxidase 1.1.3.4 0.669
2b9x FADPutative aminooxidase / 0.669
1cbo FADCholesterol oxidase 1.1.3.6 0.668
3ish FADThioredoxin reductase 1.8.1.9 0.668
3uka FADUDP-galactopyranose mutase / 0.668
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.667
3fg2 FADPutative rubredoxin reductase / 0.667
3sfe FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.667
4h6r FDAProline dehydrogenase / 0.667
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.666
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.666
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.665
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.665
3qvr FADGlucose oxidase 1.1.3.4 0.664
4u8o FDAUDP-galactopyranose mutase / 0.664
4uir FADOleate hydratase 4.2.1.53 0.664
4xxg FADCholesterol oxidase 1.1.3.6 0.664
1ng3 FADGlycine oxidase 1.4.3.19 0.663
2bac FADPutative aminooxidase / 0.663
4ysw FADXanthine dehydrogenase/oxidase / 0.663
2bab FADPutative aminooxidase / 0.662
2eq7 FADDihydrolipoyl dehydrogenase / 0.662
3axb FADPutative oxidoreductase / 0.662
3cnj FADCholesterol oxidase 1.1.3.6 0.662
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.662
4tlz FADKtzI / 0.662
4usr FADMonooxygenase / 0.662
1nhq FADNADH peroxidase 1.11.1.1 0.661
3cnd FADPolyamine oxidase FMS1 / 0.661
3ukf FDAUDP-galactopyranose mutase / 0.661
4wct FADFructosyl amine:oxygen oxidoreductase / 0.661
1d7y FADFerredoxin reductase / 0.660
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.660
3pl8 FADPyranose 2-oxidase / 0.660
3qvp FADGlucose oxidase 1.1.3.4 0.660
3r9u FADThioredoxin reductase / 0.660
5cku FADL-ornithine N(5)-monooxygenase / 0.660
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.659
3k30 ADPHistamine dehydrogenase / 0.659
4gut FADLysine-specific histone demethylase 1B 1 0.659
1n4w FADCholesterol oxidase 1.1.3.6 0.658
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.658
4hsu FADLysine-specific histone demethylase 1B 1 0.658
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.658
2b9y FADPutative aminooxidase / 0.657
2i02 FMNPyridoxamine 5'-phosphate oxidase-related, FMN-binding / 0.657
2yg6 FADPutrescine oxidase / 0.657
3cge FADCoenzyme A disulfide reductase / 0.657
3vqr FADPutative oxidoreductase / 0.657
4b65 FADL-ornithine N(5)-monooxygenase / 0.657
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.657
4u8l FDAUDP-galactopyranose mutase / 0.657
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.656
2npx NADNADH peroxidase 1.11.1.1 0.656
3ihg FADAklavinone 12-hydroxylase RdmE / 0.656
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.655
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.654
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.654
4ysh FADGlycine oxidase / 0.654
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
4a99 FADTetX family tetracycline inactivation enzyme / 0.653
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.653
5dkk FMNPredicted protein / 0.653
2cdu FADNADH oxidase / 0.652
2x8g FADThioredoxin glutathione reductase / 0.652
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.652
4xr9 NADCalS8 / 0.652
1qo8 FADFumarate reductase flavoprotein subunit / 0.651
2cdu ADPNADH oxidase / 0.651
2y48 FADLysine-specific histone demethylase 1A 1 0.651
4cnj FADL-amino acid oxidase / 0.651
4eep FMNPhototropin-2 2.7.11.1 0.651
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.650
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.650
3gsi FADDimethylglycine oxidase 1.5.3.10 0.650
3i99 FADUDP-N-acetylenolpyruvoylglucosamine reductase / 0.650
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.650
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.650
4i6g FADCryptochrome-2 / 0.650
4z26 FADPutative GMC-type oxidoreductase R135 1 0.650