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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gvu STI Abelson tyrosine-protein kinase 2 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 1.211
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 1.082
1iep STITyrosine-protein kinase ABL1 2.7.10.2 1.058
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.001
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.981
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.921
2pl0 STITyrosine-protein kinase Lck 2.7.10.2 0.895
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.879
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.869
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.811
3bv3 P39Mitogen-activated protein kinase 14 / 0.769
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.754
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.752
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.749
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.749
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.733
3bv2 P38Mitogen-activated protein kinase 14 / 0.724
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.710
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.697
3gfe P37Mitogen-activated protein kinase 14 / 0.691
4kiq 1RAMitogen-activated protein kinase 14 / 0.691
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.689
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.689
3ocg OCGMitogen-activated protein kinase 14 / 0.685
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.683
3d83 GK6Mitogen-activated protein kinase 14 / 0.681
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.680
3s4q NK0Mitogen-activated protein kinase 14 / 0.680
3mvm 39PMitogen-activated protein kinase 14 / 0.679
2hk5 1BMTyrosine-protein kinase HCK 2.7.10.2 0.678
3mvl 38PMitogen-activated protein kinase 14 / 0.674
3d7z GK5Mitogen-activated protein kinase 14 / 0.659
3bx5 304Mitogen-activated protein kinase 14 / 0.657
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.654
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.652
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.651
4eym 0RXMitogen-activated protein kinase 13 2.7.11.24 0.651