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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gu6 ADP Death-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.990
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.899
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.884
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.882
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.882
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.874
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.869
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.858
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.835
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.834
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.790
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.788
3c4z ADPRhodopsin kinase / 0.787
3c50 ADPRhodopsin kinase / 0.787
1mq4 ADPAurora kinase A 2.7.11.1 0.784
4dee ADPAurora kinase A 2.7.11.1 0.783
2pui ADPMethylthioribose kinase 2.7.1.100 0.782
3qc9 ADPRhodopsin kinase / 0.782
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.780
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.780
4ysj ADPCalmodulin-like domain protein kinase / 0.780
2pun ACPMethylthioribose kinase 2.7.1.100 0.779
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.778
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.777
5dr2 ATPAurora kinase A 2.7.11.1 0.777
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.775
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.772
3bu5 ATPInsulin receptor 2.7.10.1 0.770
2pul ACPMethylthioribose kinase 2.7.1.100 0.769
3t8o ATPRhodopsin kinase / 0.769
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.768
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.768
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.767
5dt3 ATPAurora kinase A 2.7.11.1 0.767
2olc ADPMethylthioribose kinase 2.7.1.100 0.766
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.765
5dn3 ATPAurora kinase A 2.7.11.1 0.764
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
4ceg ADPAurora kinase A 2.7.11.1 0.761
3oro AGSSerine/threonine protein kinase / 0.760
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.760
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.758
1ol6 ATPAurora kinase A 2.7.11.1 0.758
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.756
2pyw ADPMethylthioribose kinase 2.7.1.100 0.753
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.753
3c4w ATPRhodopsin kinase / 0.748
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.748
4o4d ATPKinase / 0.745
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.744
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
5dnr ATPAurora kinase A 2.7.11.1 0.744
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.743
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.743
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.743
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.742
5dos ATPAurora kinase A 2.7.11.1 0.742
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.740
3gu8 3GUDeath-associated protein kinase 1 2.7.11.1 0.739
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.739
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.738
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.738
5drd ATPAurora kinase A 2.7.11.1 0.738
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.737
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.736
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.735
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.735
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.735
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.734
3rv4 ADPBiotin carboxylase 6.3.4.14 0.733
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.733
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.732
2pz5 ACPFibroblast growth factor receptor 2 / 0.731
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.729
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.728
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.728
5dt4 ATPAurora kinase A 2.7.11.1 0.727
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.726
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.726
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.726
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.725
4q5h ANPProtein kinase OspG 2.7 0.725
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.723
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.723
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.723
4utd ACPAurora kinase A 2.7.11.1 0.723
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.722
4bn1 ADPAurora kinase A 2.7.11.1 0.722
3c4x ATPRhodopsin kinase / 0.721
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
4xlv ACPInsulin receptor 2.7.10.1 0.721
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.720
5iqb GNPBifunctional AAC/APH 2.3.1 0.720
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.719
2dwb ANPAurora kinase A 2.7.11.1 0.719
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.718
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.718
4o4e ATPKinase / 0.718
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.717
4o4f ATPKinase / 0.717
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.717
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.716
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.716
5byl GCPBifunctional AAC/APH 2.3.1 0.715
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.713
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.713
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.713
5eg3 ACPFibroblast growth factor receptor 2 / 0.713
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.712
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.712
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.712
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.711
2yaa ATPDeath-associated protein kinase 2 / 0.711
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.710
2py3 ACPFibroblast growth factor receptor 2 / 0.709
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.708
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.708
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.707
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.707
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.707
5iqh GNPBifunctional AAC/APH 2.3.1 0.707
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.706
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.704
4c3r ACPAurora kinase A 2.7.11.1 0.704
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.704
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.703
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.703
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.703
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.702
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.702
3cly ACPFibroblast growth factor receptor 2 / 0.701
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.700
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.698
3orm AGSSerine/threonine protein kinase / 0.698
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.697
3llt ANPProtein serine/threonine kinase-1 / 0.697
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.697
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.697
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.696
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.696
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.696
1ol5 ADPAurora kinase A 2.7.11.1 0.694
1u54 ACPActivated CDC42 kinase 1 / 0.694
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.694
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.694
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.694
3nie ANPMitogen-activated protein kinase / 0.693
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.693
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.692
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.692
4o1p ANPRibonuclease L / 0.692
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.690
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.690
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.690
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.690
1cm8 ANPMitogen-activated protein kinase 12 / 0.689
4pl3 ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.689
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.688
2wqe ADPAurora kinase A 2.7.11.1 0.687
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.687
2vqd AP2Biotin carboxylase 6.3.4.14 0.686
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.686
5l8k ADPAurora kinase A 2.7.11.1 0.686
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.685
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.684
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.684
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.684
5ce3 ADPProtein kinase YopO / 0.684
1ir3 ANPInsulin receptor 2.7.10.1 0.683
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.683
3ort AGSSerine/threonine protein kinase / 0.683
4ork GDPBifunctional AAC/APH 2.3.1 0.683
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.682
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.682
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
2pzp ACPFibroblast growth factor receptor 2 / 0.681
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.681
1m0w ANPGlutathione synthetase 6.3.2.3 0.680
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.680
3ork AGSSerine/threonine protein kinase / 0.680
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.680
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.679
4zs4 ATPMyosin heavy chain kinase A 2.7.11.7 0.679
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4n57 ADPAPH(2'')-Id / 0.678
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.677
2p0a ANPSynapsin-3 / 0.677
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.677
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.677
3q5i ANPProtein kinase, putative / 0.677
4jrn ANPRhoptry kinase family protein / 0.677
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.676
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.676
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.675
4qny ANPMitogen activated protein kinase, putative / 0.675
1e8x ATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2.7.1.153 0.674
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.674
3g8c ADPBiotin carboxylase 6.3.4.14 0.674
5l8l ADPAurora kinase A 2.7.11.1 0.674
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.673
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.673
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.672
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.672
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.672
5l8j ADPAurora kinase A 2.7.11.1 0.672
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.671
3orp AGSSerine/threonine protein kinase / 0.670
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.669
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.667
5iqg GDPBifunctional AAC/APH 2.3.1 0.667
5iqd GNPBifunctional AAC/APH 2.3.1 0.666
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.664
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.664
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.664
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.663
2j9g ADPBiotin carboxylase 6.3.4.14 0.663
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.661
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.661
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.661
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.661
2pup ADPMethylthioribose kinase 2.7.1.100 0.661
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.659
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.659
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.659
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.659
5iqf GDPBifunctional AAC/APH 2.3.1 0.659
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.658
4mam A12N5-carboxyaminoimidazole ribonucleotide synthase / 0.658
3ori AGSSerine/threonine protein kinase / 0.657
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.657
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.656
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
5iqa GNPBifunctional AAC/APH 2.3.1 0.656
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.655
3lla ACPMyosin heavy chain kinase A 2.7.11.7 0.655
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
2zdg ADPD-alanine--D-alanine ligase / 0.654
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.652
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
1h1w ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.651
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
1ne4 RP1cAMP-dependent protein kinase type I-alpha regulatory subunit / 0.651
5c93 ACPTwo-component system histidine protein kinase / 0.651
5iqi GNPBifunctional AAC/APH 2.3.1 0.651
5l6w AGSLIM domain kinase 1 2.7.11.1 0.651
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.650
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650
4mv8 ACPBiotin carboxylase 6.3.4.14 0.650