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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gmb FAD 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.338
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.086
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.067
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.035
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.032
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.023
4bjz FADProbable salicylate monooxygenase / 0.909
4bk3 FADProbable salicylate monooxygenase / 0.896
4k5r FADOxygenase / 0.860
4bk2 FADProbable salicylate monooxygenase / 0.856
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.852
4j2w FADKynurenine 3-monooxygenase / 0.830
4j33 FADKynurenine 3-monooxygenase / 0.819
2qa1 FADPgaE / 0.818
4j36 FADKynurenine 3-monooxygenase / 0.800
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.798
3ept FDAPutative FAD-monooxygenase / 0.794
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.793
1zk7 FADMercuric reductase 1.16.1.1 0.784
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.782
1zx9 FADMercuric reductase 1.16.1.1 0.781
4opc FDAConserved Archaeal protein / 0.781
3atq FDAConserved Archaeal protein / 0.776
3rp8 FADFAD-dependent urate hydroxylase / 0.774
2qa2 FADPolyketide oxygenase CabE / 0.773
4opg FDAConserved Archaeal protein / 0.773
4j34 FADKynurenine 3-monooxygenase / 0.771
4opi FDAConserved Archaeal protein / 0.771
4a6n FADTetX family tetracycline inactivation enzyme / 0.769
4opl FDAConserved Archaeal protein / 0.766
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.765
3atr FDAConserved Archaeal protein / 0.765
4hb9 FADUncharacterized protein / 0.764
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.761
2wba FADTrypanothione reductase 1.8.1.12 0.761
1trb FADThioredoxin reductase 1.8.1.9 0.755
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.755
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.752
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.751
4opt FDAConserved Archaeal protein / 0.750
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.749
4nte FADDepH / 0.749
1ges FADGlutathione reductase 1.8.1.7 0.748
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.745
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.745
4gcm FADThioredoxin reductase 1.8.1.9 0.743
1b4v FADCholesterol oxidase 1.1.3.6 0.741
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.740
2q0k FADThioredoxin reductase 1.8.1.9 0.740
4j31 FADKynurenine 3-monooxygenase / 0.740
1feb FADTrypanothione reductase 1.8.1.12 0.737
4k2x FADPolyketide oxygenase/hydroxylase / 0.736
2xdo FADTetX family tetracycline inactivation enzyme / 0.734
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.734
3icr FADCoenzyme A disulfide reductase / 0.734
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.733
3lad FADDihydrolipoyl dehydrogenase / 0.733
4a5l FADThioredoxin reductase / 0.732
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.731
4ccq FADThioredoxin reductase / 0.731
4opu FDAConserved Archaeal protein / 0.731
4x4j FADPutative oxygenase / 0.731
2jk6 FADTrypanothione reductase / 0.730
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.730
3fmw FADOxygenase / 0.730
4j57 FADThioredoxin reductase 2 1.8.1.9 0.730
4jnq FDAThioredoxin reductase / 0.729
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.728
4opd FDAConserved Archaeal protein / 0.728
1geu FADGlutathione reductase 1.8.1.7 0.726
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.726
2hqm FADGlutathione reductase 1.8.1.7 0.725
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.724
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.723
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.722
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.722
4mih FADPyranose 2-oxidase 1.1.3.10 0.722
2r9z FADGlutathione amide reductase / 0.721
3axb FADPutative oxidoreductase / 0.720
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.719
4a99 FADTetX family tetracycline inactivation enzyme / 0.719
4icy FADPgaE / 0.719
4ntc FADThioredoxin reductase gliT / 0.719
1k0l FADp-hydroxybenzoate hydroxylase / 0.716
4i58 FADCyclohexylamine Oxidase / 0.716
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.715
1phh FADp-hydroxybenzoate hydroxylase / 0.715
1tde FADThioredoxin reductase 1.8.1.9 0.715
2wp5 FADTrypanothione reductase / 0.715
2zzc FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.715
3k4n FADPyranose 2-oxidase / 0.715
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.715
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.714
1fea FADTrypanothione reductase 1.8.1.12 0.713
1fec FADTrypanothione reductase 1.8.1.12 0.713
2v6o FADThioredoxin glutathione reductase / 0.713
3f8d FADNADH oxidase/thioredoxin reductase / 0.713
4up3 FADThioredoxin reductase / 0.712
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.711
3urh FADDihydrolipoyl dehydrogenase / 0.711
3lsm SFDPyranose 2-oxidase / 0.710
4cbq FADThioredoxin reductase / 0.710
1ger FADGlutathione reductase 1.8.1.7 0.709
2igo FADPyranose 2-oxidase / 0.709
2ign FADPyranose 2-oxidase / 0.707
3lsi FADPyranose 2-oxidase / 0.707
1k0j FADp-hydroxybenzoate hydroxylase / 0.706
2rab FADGlutathione amide reductase / 0.706
2x8h FADThioredoxin glutathione reductase / 0.706
3cgd FADCoenzyme A disulfide reductase / 0.706
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.704
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.704
2zbw FADFerredoxin--NADP reductase / 0.704
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.703
2whd FADThioredoxin reductase / 0.703
4mok FADPyranose 2-oxidase / 0.703
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.702
4jn9 FADDepH / 0.701
1d7l RFLp-hydroxybenzoate hydroxylase / 0.700
2tpr FADTrypanothione reductase 1.8.1.12 0.700
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.700
5dbj FADFADH2-dependent halogenase PltA / 0.699
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.697
1ve9 FADD-amino-acid oxidase 1.4.3.3 0.697
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.697
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.697
2wow FADTrypanothione reductase / 0.697
3k4c FADPyranose 2-oxidase / 0.697
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
4a65 FADThioredoxin reductase / 0.697
1cbo FADCholesterol oxidase 1.1.3.6 0.696
1gxf FADTrypanothione reductase 1.8.1.12 0.696
4ntd FADThioredoxin reductase / 0.696
3lsh FADPyranose 2-oxidase / 0.695
3pl8 FADPyranose 2-oxidase / 0.695
3r9u FADThioredoxin reductase / 0.695
4fwe FADLysine-specific histone demethylase 1B 1 0.695
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.694
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.694
1bzl FADTrypanothione reductase 1.8.1.12 0.693
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.693
1z6l FADPolyamine oxidase FMS1 / 0.693
4nev FADTrypanothione reductase / 0.693
5buk FADFADH2-dependent halogenase / 0.692
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.691
4at0 FADPossible succinate dehydrogenase / 0.691
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.691
3ka7 FADPutative oxidoreductase / 0.690
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.690
1ryi FADGlycine oxidase 1.4.3.19 0.689
1tyt FADTrypanothione reductase 1.8.1.12 0.689
1xpq FADPolyamine oxidase FMS1 / 0.689
3fg2 FADPutative rubredoxin reductase / 0.689
3p9u FADTetX family tetracycline inactivation enzyme / 0.689
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.689
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.688
4b1b FADThioredoxin reductase 1.8.1.9 0.688
4ysh FADGlycine oxidase / 0.688
2x8g FADThioredoxin glutathione reductase / 0.687
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.687
1b8s FADCholesterol oxidase 1.1.3.6 0.686
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.686
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.685
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.685
2yqu FADDihydrolipoyl dehydrogenase / 0.684
4cnk FADL-amino acid oxidase / 0.684
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.683
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.683
1tdo FADL-amino-acid oxidase 1.4.3.2 0.682
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.682
3cty FADProbable thioredoxin reductase / 0.681
3ics FADCoenzyme A disulfide reductase / 0.681
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.681
4jq9 FADDihydrolipoyl dehydrogenase / 0.681
1cl0 FADThioredoxin reductase 1.8.1.9 0.680
1f8w FADNADH peroxidase 1.11.1.1 0.680
2z6c FMNPhototropin-1 2.7.11.1 0.680
3bi2 FADPolyamine oxidase FMS1 / 0.680
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.679
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.679
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.678
5l3d FADLysine-specific histone demethylase 1A 1 0.678
2eq7 FADDihydrolipoyl dehydrogenase / 0.677
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.677
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.676
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.676
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.676
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.676
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.676
1cc2 FADCholesterol oxidase 1.1.3.6 0.675
4ech FADPolyamine oxidase FMS1 / 0.675
4j56 FADThioredoxin reductase 2 1.8.1.9 0.675
2w0h FADTrypanothione reductase / 0.674
4guv FADTetX family tetracycline inactivation enzyme / 0.674
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.673
2eq8 FADDihydrolipoyl dehydrogenase / 0.673
4dna FADProbable glutathione reductase / 0.673
5i39 FADL-amino acid deaminase / 0.673
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.672
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.672
4gdp FADPolyamine oxidase FMS1 / 0.672
4la1 FADThioredoxin glutathione reductase / 0.672
1npx FADNADH peroxidase 1.11.1.1 0.671
2jb2 FADL-amino acid oxidase / 0.671
2x3n FADProbable FAD-dependent monooxygenase / 0.670
2y48 FADLysine-specific histone demethylase 1A 1 0.670
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.670
2bac FADPutative aminooxidase / 0.669
2jae FADL-amino acid oxidase / 0.669
2yvj FADFerredoxin reductase / 0.669
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.669
1ng4 FADGlycine oxidase 1.4.3.19 0.668
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.668
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.668
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.667
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.667
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.667
3d72 FADVivid PAS protein VVD / 0.666
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.665
1zmd FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.664
2cdu FADNADH oxidase / 0.664
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.664
4wx1 FDAUDP-galactopyranose mutase / 0.664
2gqw FADFerredoxin reductase / 0.663
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
3itj FADThioredoxin reductase 1 1.8.1.9 0.663
4eeu FMNPhototropin-2 2.7.11.1 0.663
1nhs FADNADH peroxidase 1.11.1.1 0.662
1tdn FADL-amino-acid oxidase 1.4.3.2 0.662
2jb1 FADL-amino acid oxidase / 0.662
4u8l FDAUDP-galactopyranose mutase / 0.662
5j3w FMNSensory box protein / 0.662
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.661
1nhq FADNADH peroxidase 1.11.1.1 0.661
2iid FADL-amino-acid oxidase 1.4.3.2 0.661
3cnt FADPolyamine oxidase FMS1 / 0.661
3dme FADPutative conserved exported protein / 0.661
1d7y FADFerredoxin reductase / 0.660
2eq9 FADDihydrolipoyl dehydrogenase / 0.660
1ojt FADDihydrolipoyl dehydrogenase / 0.659
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
4em3 FADCoenzyme A disulfide reductase / 0.658
1typ FADTrypanothione reductase 1.8.1.12 0.657
2dvl FADAcyl-CoA dehydrogenase / 0.657
2fje FADAdenylylsulfate reductase, subunit A (AprA) / 0.657
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.657
1nhr FADNADH peroxidase 1.11.1.1 0.656
2eq6 FADDihydrolipoyl dehydrogenase / 0.656
3ad9 FADSubunit beta of sarcosine oxidase / 0.656
4ccr FADThioredoxin reductase / 0.656
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.656
1s4m LUMRiboflavin biosynthesis protein / 0.655
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.655
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.655
1jnr FADAdenylylsulfate reductase, subunit A (AprA) / 0.654
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.654
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.653
2gew FADCholesterol oxidase 1.1.3.6 0.653
3cnj FADCholesterol oxidase 1.1.3.6 0.653
3ict FADCoenzyme A disulfide reductase / 0.653
4u2t FADCholesterol oxidase 1.1.3.6 0.653
4u8n FDAUDP-galactopyranose mutase / 0.653
4yus FMNFamily 3 adenylate cyclase / 0.653
5djt FMNNPH1-2 / 0.653
2gmj FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.652
3hdy FADUDP-galactopyranose mutase / 0.652
3hgo FMN12-oxophytodienoate reductase 3 1.3.1.42 0.652
2z6d FMNPhototropin-2 2.7.11.1 0.651
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.651
2pr5 FMNBlue-light photoreceptor / 0.650