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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gi3 B10 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gi3 B10Mitogen-activated protein kinase 14 / 1.319
3p5k P5KMitogen-activated protein kinase 14 / 0.906
3hv7 1AUMitogen-activated protein kinase 14 / 0.808
1kv2 B96Mitogen-activated protein kinase 14 / 0.800
2yiw YIWMitogen-activated protein kinase 14 / 0.777
3nnx EDDMitogen-activated protein kinase 14 / 0.777
3p7a P7AMitogen-activated protein kinase 14 / 0.770
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.757
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.752
4e5i 0N9Polymerase acidic protein / 0.744
3hv5 R24Mitogen-activated protein kinase 14 / 0.735
2yis YISMitogen-activated protein kinase 14 / 0.734
3hv6 R39Mitogen-activated protein kinase 14 / 0.732
3hv3 R49Mitogen-activated protein kinase 14 / 0.725
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.723
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.707
3gcu R48Mitogen-activated protein kinase 14 / 0.704
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.704
3gcs BAXMitogen-activated protein kinase 14 / 0.702
3lfe Z84Mitogen-activated protein kinase 14 / 0.700
3pg3 DG7Mitogen-activated protein kinase 14 / 0.695
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.693
3lff Z83Mitogen-activated protein kinase 14 / 0.691
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.690
3bv2 P38Mitogen-activated protein kinase 14 / 0.687
3ugc 046Tyrosine-protein kinase JAK2 / 0.687
3d83 GK6Mitogen-activated protein kinase 14 / 0.685
2puu G2GMitogen-activated protein kinase 14 / 0.684
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.683
1kv1 BMUMitogen-activated protein kinase 14 / 0.681
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.681
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.681
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.680
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.678
3p7c P7CMitogen-activated protein kinase 14 / 0.677
4aa0 AA0Mitogen-activated protein kinase 14 / 0.676
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.675
1wbv LI3Mitogen-activated protein kinase 14 / 0.667
3hv4 L51Mitogen-activated protein kinase 14 / 0.667
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.662
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
3nnw EDDMitogen-activated protein kinase 14 / 0.658
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.655
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.654
3uvq FS8Mitogen-activated protein kinase 14 / 0.653
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.653
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.652
4ja8 1K9Isocitrate dehydrogenase [NADP], mitochondrial 1.1.1.42 0.652
1w82 L10Mitogen-activated protein kinase 14 / 0.650
3uvr 06FMitogen-activated protein kinase 14 / 0.650