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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gi2 GHW Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gi2 GHWDihydrofolate reductase 1.5.1.3 1.138
3ghw GHWDihydrofolate reductase 1.5.1.3 1.044
3ghv GHCDihydrofolate reductase 1.5.1.3 0.995
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.861
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.843
4kfj FOLDihydrofolate reductase 1.5.1.3 0.807
1hfr MOTDihydrofolate reductase 1.5.1.3 0.803
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.800
4m6k FOLDihydrofolate reductase 1.5.1.3 0.787
1hfq MOTDihydrofolate reductase 1.5.1.3 0.781
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.774
1hfp MOTDihydrofolate reductase 1.5.1.3 0.769
4keb FOLDihydrofolate reductase 1.5.1.3 0.768
1dhf FOLDihydrofolate reductase 1.5.1.3 0.767
4i1n FOLDihydrofolate reductase 1.5.1.3 0.758
4i13 FOLDihydrofolate reductase 1.5.1.3 0.752
3eig MTXDihydrofolate reductase 1.5.1.3 0.750
2w3m FOLDihydrofolate reductase 1.5.1.3 0.747
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.746
5hi6 MTXDihydrofolate reductase / 0.742
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.741
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.740
4x5g FOLDihydrofolate reductase 1.5.1.3 0.740
4p68 MTXDihydrofolate reductase / 0.736
4x5f FOLDihydrofolate reductase 1.5.1.3 0.734
3tqb FOLDihydrofolate reductase / 0.732
1u70 MTXDihydrofolate reductase 1.5.1.3 0.731
4m6l 21VDihydrofolate reductase 1.5.1.3 0.730
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.727
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.725
2qk8 MTXDihydrofolate reductase / 0.722
4p66 MTXDihydrofolate reductase / 0.721
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.720
7dfr FOLDihydrofolate reductase 1.5.1.3 0.718
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.716
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.716
1jom FFODihydrofolate reductase 1.5.1.3 0.715
4qi9 MTXDihydrofolate reductase / 0.715
1df7 MTXDihydrofolate reductase 1.5.1.3 0.714
1ohk COPDihydrofolate reductase 1.5.1.3 0.714
1drf FOLDihydrofolate reductase 1.5.1.3 0.713
1dre MTXDihydrofolate reductase 1.5.1.3 0.710
3tq9 MTXDihydrofolate reductase / 0.709
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.706
2drc MTXDihydrofolate reductase 1.5.1.3 0.704
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.702
2dhf DZFDihydrofolate reductase 1.5.1.3 0.701
1re7 FOLDihydrofolate reductase 1.5.1.3 0.697
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.696
1u72 MTXDihydrofolate reductase 1.5.1.3 0.696
4fhb FOLDihydrofolate reductase 1.5.1.3 0.695
1ohj COPDihydrofolate reductase 1.5.1.3 0.694
1dls MTXDihydrofolate reductase 1.5.1.3 0.691
1dyj DDFDihydrofolate reductase 1.5.1.3 0.690
1jol FFODihydrofolate reductase 1.5.1.3 0.689
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.686
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.686
1e26 GPBDihydrofolate reductase 1.5.1.3 0.683
4x5i FOLDihydrofolate reductase 1.5.1.3 0.680
2d0k FOLDihydrofolate reductase 1.5.1.3 0.678
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.677
5ccc DDFDihydrofolate reductase 1.5.1.3 0.676
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.674
4x5h FOLDihydrofolate reductase 1.5.1.3 0.673
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.670
3och 2MXDihydrofolate reductase 1.5.1.3 0.670
2zza FOLDihydrofolate reductase / 0.669
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.668
3drc MTXDihydrofolate reductase 1.5.1.3 0.668
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.667
3dau MTXDihydrofolate reductase 1.5.1.3 0.664
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.664
4dfr MTXDihydrofolate reductase 1.5.1.3 0.663
1dyi FOLDihydrofolate reductase 1.5.1.3 0.660
3fri SAH16S rRNA methylase / 0.655
3frd DHFDihydrofolate reductase 1.5.1.3 0.654
2g1m 4HGEgl nine homolog 1 / 0.653
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.652
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.652