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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ghw GHW Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ghw GHWDihydrofolate reductase 1.5.1.3 1.091
3gi2 GHWDihydrofolate reductase 1.5.1.3 1.044
3ghv GHCDihydrofolate reductase 1.5.1.3 1.018
4m6k FOLDihydrofolate reductase 1.5.1.3 0.867
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.857
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.857
1dhf FOLDihydrofolate reductase 1.5.1.3 0.829
4kfj FOLDihydrofolate reductase 1.5.1.3 0.822
2w3m FOLDihydrofolate reductase 1.5.1.3 0.804
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.798
4i1n FOLDihydrofolate reductase 1.5.1.3 0.780
4x5g FOLDihydrofolate reductase 1.5.1.3 0.777
1hfq MOTDihydrofolate reductase 1.5.1.3 0.770
4m6l 21VDihydrofolate reductase 1.5.1.3 0.765
3eig MTXDihydrofolate reductase 1.5.1.3 0.754
1hfp MOTDihydrofolate reductase 1.5.1.3 0.749
1hfr MOTDihydrofolate reductase 1.5.1.3 0.747
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.746
4i13 FOLDihydrofolate reductase 1.5.1.3 0.742
1dyj DDFDihydrofolate reductase 1.5.1.3 0.741
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.741
1drf FOLDihydrofolate reductase 1.5.1.3 0.740
2dhf DZFDihydrofolate reductase 1.5.1.3 0.735
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.733
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.731
1u72 MTXDihydrofolate reductase 1.5.1.3 0.731
3tqb FOLDihydrofolate reductase / 0.731
4keb FOLDihydrofolate reductase 1.5.1.3 0.729
1ohk COPDihydrofolate reductase 1.5.1.3 0.728
1dls MTXDihydrofolate reductase 1.5.1.3 0.725
4x5f FOLDihydrofolate reductase 1.5.1.3 0.724
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.722
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.722
4p68 MTXDihydrofolate reductase / 0.722
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.720
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.719
1u70 MTXDihydrofolate reductase 1.5.1.3 0.716
4fhb FOLDihydrofolate reductase 1.5.1.3 0.715
3dfr MTXDihydrofolate reductase 1.5.1.3 0.714
2qk8 MTXDihydrofolate reductase / 0.712
1jom FFODihydrofolate reductase 1.5.1.3 0.711
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.711
4kjj FOLDihydrofolate reductase 1.5.1.3 0.711
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.710
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.710
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.710
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.708
4dfr MTXDihydrofolate reductase 1.5.1.3 0.708
7dfr FOLDihydrofolate reductase 1.5.1.3 0.707
1dre MTXDihydrofolate reductase 1.5.1.3 0.706
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.704
4x5h FOLDihydrofolate reductase 1.5.1.3 0.700
4p66 MTXDihydrofolate reductase / 0.699
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.697
1ohj COPDihydrofolate reductase 1.5.1.3 0.695
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.695
1e26 GPBDihydrofolate reductase 1.5.1.3 0.690
4qi9 MTXDihydrofolate reductase / 0.690
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.684
1dhi MTXDihydrofolate reductase 1.5.1.3 0.680
3drc MTXDihydrofolate reductase 1.5.1.3 0.680
5hi6 MTXDihydrofolate reductase / 0.680
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.676
4x5i FOLDihydrofolate reductase 1.5.1.3 0.676
5ccc DDFDihydrofolate reductase 1.5.1.3 0.676
3frd DHFDihydrofolate reductase 1.5.1.3 0.672
2zza FOLDihydrofolate reductase / 0.671
1rb2 FOLDihydrofolate reductase 1.5.1.3 0.670
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.670
3dau MTXDihydrofolate reductase 1.5.1.3 0.669
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.668
1tdr MTXDihydrofolate reductase 1.5.1.3 0.668
1dyh DZFDihydrofolate reductase 1.5.1.3 0.667
1dyi FOLDihydrofolate reductase 1.5.1.3 0.665
1df7 MTXDihydrofolate reductase 1.5.1.3 0.664
3tq9 MTXDihydrofolate reductase / 0.663
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.661
1dhj MTXDihydrofolate reductase 1.5.1.3 0.657
1jol FFODihydrofolate reductase 1.5.1.3 0.657
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.657
1ao8 MTXDihydrofolate reductase 1.5.1.3 0.656
1dra MTXDihydrofolate reductase 1.5.1.3 0.655
2drc MTXDihydrofolate reductase 1.5.1.3 0.653
3och 2MXDihydrofolate reductase 1.5.1.3 0.652