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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gd3 FAD Apoptosis-inducing factor 1, mitochondrial 1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.390
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.086
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.067
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.045
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.039
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 1.018
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.992
1d7y FADFerredoxin reductase / 0.875
2gqw FADFerredoxin reductase / 0.871
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.870
2gr3 FADFerredoxin reductase / 0.869
1f3p FADFerredoxin reductase / 0.859
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.859
2gr0 FADFerredoxin reductase / 0.846
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.831
1q1w FADPutidaredoxin reductase 1.18.1.5 0.809
4opg FDAConserved Archaeal protein / 0.801
4opi FDAConserved Archaeal protein / 0.800
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.797
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.797
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.796
2yvf FADFerredoxin reductase / 0.795
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.791
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.788
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.788
4opt FDAConserved Archaeal protein / 0.782
3atr FDAConserved Archaeal protein / 0.779
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.779
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.773
3atq FDAConserved Archaeal protein / 0.769
3fg2 FADPutative rubredoxin reductase / 0.768
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.765
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.761
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.759
4j33 FADKynurenine 3-monooxygenase / 0.756
4gdp FADPolyamine oxidase FMS1 / 0.755
2yvj FADFerredoxin reductase / 0.753
4opc FDAConserved Archaeal protein / 0.753
1rsg FADPolyamine oxidase FMS1 / 0.751
3klj FADNADH-rubredoxin oxidoreductase 1.18.1.1 0.751
1w4x FADPhenylacetone monooxygenase 1.14.13.92 0.748
2gr1 FADFerredoxin reductase / 0.748
4j36 FADKynurenine 3-monooxygenase / 0.741
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.739
4j34 FADKynurenine 3-monooxygenase / 0.737
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.736
4gcm FADThioredoxin reductase 1.8.1.9 0.733
3icr FADCoenzyme A disulfide reductase / 0.729
1yy5 FADPolyamine oxidase FMS1 / 0.727
3ish FADThioredoxin reductase 1.8.1.9 0.725
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.723
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.719
4opu FDAConserved Archaeal protein / 0.719
2dw4 FADLysine-specific histone demethylase 1A 1 0.718
4h4y FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.715
2zbw FADFerredoxin--NADP reductase / 0.713
1f8w FADNADH peroxidase 1.11.1.1 0.712
4h4s FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.712
4j2w FADKynurenine 3-monooxygenase / 0.712
5hxw FADL-amino acid deaminase / 0.711
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.709
3cgd FADCoenzyme A disulfide reductase / 0.709
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.708
3bi5 FADPolyamine oxidase FMS1 / 0.706
3qj4 FADRenalase / 0.706
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.706
1q1r FADPutidaredoxin reductase 1.18.1.5 0.705
4x4j FADPutative oxygenase / 0.705
1zx9 FADMercuric reductase 1.16.1.1 0.704
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.704
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.703
4h4z FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.703
3bi2 FADPolyamine oxidase FMS1 / 0.702
2ylz FADPhenylacetone monooxygenase 1.14.13.92 0.700
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.700
4k5r FADOxygenase / 0.699
5c3j FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.699
1ng3 FADGlycine oxidase 1.4.3.19 0.697
2npx FADNADH peroxidase 1.11.1.1 0.697
3cge FADCoenzyme A disulfide reductase / 0.697
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.697
3k30 ADPHistamine dehydrogenase / 0.697
4em3 FADCoenzyme A disulfide reductase / 0.696
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.696
4h4q FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.696
3cgc FADCoenzyme A disulfide reductase / 0.695
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.695
2xdo FADTetX family tetracycline inactivation enzyme / 0.694
4j31 FADKynurenine 3-monooxygenase / 0.694
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.694
3pvc FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.692
1zk7 FADMercuric reductase 1.16.1.1 0.691
2q0k FADThioredoxin reductase 1.8.1.9 0.691
2x3n FADProbable FAD-dependent monooxygenase / 0.691
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.690
3cgb FADCoenzyme A disulfide reductase / 0.690
3f8d FADNADH oxidase/thioredoxin reductase / 0.690
4fwj FADLysine-specific histone demethylase 1B 1 0.690
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.689
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.689
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.689
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.688
3rha FDAPutrescine oxidase / 0.688
1h83 FADPolyamine oxidase 1.5.3.14 0.687
2eq6 FADDihydrolipoyl dehydrogenase / 0.686
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.686
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.686
4usr FADMonooxygenase / 0.686
2yqu FADDihydrolipoyl dehydrogenase / 0.685
4xwz FADFructosyl amine:oxygen oxidoreductase / 0.685
2yg6 FADPutrescine oxidase / 0.684
4ntc FADThioredoxin reductase gliT / 0.684
1gre FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
2yg7 FADPutrescine oxidase / 0.683
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.683
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.682
4h50 FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.682
2rgo FADAlpha-Glycerophosphate Oxidase / 0.681
3f8r NAPNADH oxidase/thioredoxin reductase / 0.681
3ics FADCoenzyme A disulfide reductase / 0.681
3sgl FADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.681
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.681
4z2t FAD2-hydroxybiphenyl-3-monooxygenase / 0.681
3gwf FADCyclohexanone monooxygenase / 0.680
4h4w FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.679
2q7v FADThioredoxin reductase / 0.678
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.678
4bk2 FADProbable salicylate monooxygenase / 0.678
1f8s FADL-amino-acid oxidase 1.4.3.2 0.677
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.677
3vqr FADPutative oxidoreductase / 0.677
4b1b FADThioredoxin reductase 1.8.1.9 0.677
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.676
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.675
3axb FADPutative oxidoreductase / 0.675
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.675
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.675
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.675
1ges FADGlutathione reductase 1.8.1.7 0.674
1nhp FADNADH peroxidase 1.11.1.1 0.674
1nhq FADNADH peroxidase 1.11.1.1 0.674
1nhs FADNADH peroxidase 1.11.1.1 0.674
1tdf FADThioredoxin reductase 1.8.1.9 0.674
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.674
4gav FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.674
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.673
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.673
3cn8 FADPolyamine oxidase FMS1 / 0.673
2yg4 FADPutrescine oxidase / 0.672
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.672
1npx FADNADH peroxidase 1.11.1.1 0.671
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.671
4nte FADDepH / 0.671
3ict FADCoenzyme A disulfide reductase / 0.670
4hb9 FADUncharacterized protein / 0.670
1f8r FADL-amino-acid oxidase 1.4.3.2 0.669
2eq8 FADDihydrolipoyl dehydrogenase / 0.669
4xbf FADLysine-specific histone demethylase 1A 1 0.669
1joa FADNADH peroxidase 1.11.1.1 0.668
1nhr FADNADH peroxidase 1.11.1.1 0.668
1tde FADThioredoxin reductase 1.8.1.9 0.668
2w0h FADTrypanothione reductase / 0.668
2wow FADTrypanothione reductase / 0.668
3nlc FADUncharacterized protein / 0.668
4a5l FADThioredoxin reductase / 0.668
4g74 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.668
3dme FADPutative conserved exported protein / 0.667
4up3 FADThioredoxin reductase / 0.667
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.666
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.666
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.666
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.665
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.665
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.665
1trb FADThioredoxin reductase 1.8.1.9 0.664
3sz0 FADSulfide-quinone reductase / 0.664
4aox FADSteroid monooxygenase / 0.664
4guv FADTetX family tetracycline inactivation enzyme / 0.664
4usq FADPyridine nucleotide-disulfide oxidoreductase / 0.664
2eix FADNADH-cytochrome b5 reductase / 0.663
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.663
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.663
4bk3 FADProbable salicylate monooxygenase / 0.663
4g73 FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.663
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.662
4mo2 FDAUDP-galactopyranose mutase / 0.662
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.661
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.661
4emw FADCoenzyme A disulfide reductase / 0.661
3bg7 FADPyranose 2-oxidase / 0.659
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.659
4ynt FDAGlucose oxidase, putative / 0.659
1k0j FADp-hydroxybenzoate hydroxylase / 0.658
2xyo FADTetX family tetracycline inactivation enzyme / 0.658
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.658
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.657
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.657
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.657
3fpz AHZThiamine thiazole synthase / 0.657
3t37 FADPyridoxine 4-oxidase / 0.657
3we0 FADLysine 2-monooxygenase / 0.657
4fwf FADLysine-specific histone demethylase 1B 1 0.657
4kx6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.657
1ryi FADGlycine oxidase 1.4.3.19 0.656
2cdu FADNADH oxidase / 0.656
1h81 FADPolyamine oxidase 1.5.3.14 0.655
2ba9 FADPutative aminooxidase / 0.655
4ech FADPolyamine oxidase FMS1 / 0.655
4em4 FADCoenzyme A disulfide reductase / 0.655
4jq9 FADDihydrolipoyl dehydrogenase / 0.655
4uir FADOleate hydratase 4.2.1.53 0.655
1fec FADTrypanothione reductase 1.8.1.12 0.654
1k0l FADp-hydroxybenzoate hydroxylase / 0.654
2vvl FADMonoamine oxidase N 1.4.3.4 0.654
2zz0 FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.654
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.654
5buk FADFADH2-dependent halogenase / 0.654
5c2t FADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial / 0.654
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.653
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.653
2y48 FADLysine-specific histone demethylase 1A 1 0.653
4ykf FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.653
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
2hqm FADGlutathione reductase 1.8.1.7 0.652
4fwe FADLysine-specific histone demethylase 1B 1 0.652
4hsu FADLysine-specific histone demethylase 1B 1 0.652
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.652
4rsl FADFructosyl peptide oxidase / 0.652
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.651
2yg5 FADPutrescine oxidase / 0.651
3ka7 FADPutative oxidoreductase / 0.651
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.651
4mih FADPyranose 2-oxidase 1.1.3.10 0.651
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.650