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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3gcu R48 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3gcu R48Mitogen-activated protein kinase 14 / 1.263
3hv4 L51Mitogen-activated protein kinase 14 / 1.177
3hv5 R24Mitogen-activated protein kinase 14 / 1.070
3gcv SS6Mitogen-activated protein kinase 14 / 0.869
1w82 L10Mitogen-activated protein kinase 14 / 0.778
3p5k P5KMitogen-activated protein kinase 14 / 0.770
3gcq 1BUMitogen-activated protein kinase 14 / 0.769
3hv6 R39Mitogen-activated protein kinase 14 / 0.766
3nnw EDDMitogen-activated protein kinase 14 / 0.766
3p7c P7CMitogen-activated protein kinase 14 / 0.755
3d83 GK6Mitogen-activated protein kinase 14 / 0.752
2bak AQZMitogen-activated protein kinase 14 / 0.749
3uvr 06FMitogen-activated protein kinase 14 / 0.749
4a9y AQZMitogen-activated protein kinase 14 / 0.749
3nnx EDDMitogen-activated protein kinase 14 / 0.747
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.746
3lfb Z87Mitogen-activated protein kinase 14 / 0.744
3lfe Z84Mitogen-activated protein kinase 14 / 0.735
3e93 19BMitogen-activated protein kinase 14 / 0.733
1kv2 B96Mitogen-activated protein kinase 14 / 0.731
4f7n 0SVCyclin-dependent kinase 8 2.7.11.22 0.729
3p7b P7BMitogen-activated protein kinase 14 / 0.725
4f6s 0SQCyclin-dependent kinase 8 2.7.11.22 0.725
3npc B96Mitogen-activated protein kinase 9 2.7.11.24 0.723
4h1m 0YJProtein-tyrosine kinase 2-beta 2.7.10.2 0.720
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.716
4ksp 1SUSerine/threonine-protein kinase B-raf 2.7.11.1 0.708
1wbs LI2Mitogen-activated protein kinase 14 / 0.705
3gi3 B10Mitogen-activated protein kinase 14 / 0.704
3lff Z83Mitogen-activated protein kinase 14 / 0.700
1wbt WBTMitogen-activated protein kinase 14 / 0.699
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.698
4fc0 0T2Serine/threonine-protein kinase B-raf 2.7.11.1 0.697
1kv1 BMUMitogen-activated protein kinase 14 / 0.695
2yiw YIWMitogen-activated protein kinase 14 / 0.693
4aa0 AA0Mitogen-activated protein kinase 14 / 0.693
3bv2 P38Mitogen-activated protein kinase 14 / 0.692
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.692
3hv7 1AUMitogen-activated protein kinase 14 / 0.691
1wbv LI3Mitogen-activated protein kinase 14 / 0.690
2puu G2GMitogen-activated protein kinase 14 / 0.689
2yis YISMitogen-activated protein kinase 14 / 0.689
3fzt 4JZProtein-tyrosine kinase 2-beta 2.7.10.2 0.689
3bv3 P39Mitogen-activated protein kinase 14 / 0.688
3fzs B96Protein-tyrosine kinase 2-beta 2.7.10.2 0.684
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.684
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.684
3p7a P7AMitogen-activated protein kinase 14 / 0.683
3nnu EDBMitogen-activated protein kinase 14 / 0.679
1w83 L11Mitogen-activated protein kinase 14 / 0.677
3hv3 R49Mitogen-activated protein kinase 14 / 0.677
3o8u BMUMitogen-activated protein kinase 14 / 0.675
4f70 0STCyclin-dependent kinase 8 2.7.11.22 0.671
4h1j 0YHProtein-tyrosine kinase 2-beta 2.7.10.2 0.666
3gcs BAXMitogen-activated protein kinase 14 / 0.661
1wbn L09Mitogen-activated protein kinase 14 / 0.657
4eyj N61Mitogen-activated protein kinase 13 2.7.11.24 0.656
2zb0 GK3Mitogen-activated protein kinase 14 / 0.655
4aac AAVMitogen-activated protein kinase 14 / 0.652
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.651
4f7l 0SOCyclin-dependent kinase 8 2.7.11.22 0.650