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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3g5e Q74 Aldose reductase 1.1.1.21

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3g5e Q74Aldose reductase 1.1.1.21 1.201
4gca 2X9Aldose reductase 1.1.1.21 1.122
1t40 ID5Aldose reductase 1.1.1.21 0.914
2pdh 47DAldose reductase 1.1.1.21 0.914
2pdn 47DAldose reductase 1.1.1.21 0.910
2fz9 ZSTAldose reductase 1.1.1.21 0.909
1z3n 3NAAldose reductase 1.1.1.21 0.891
2dux ZSTAldose reductase 1.1.1.21 0.854
2pdg 47DAldose reductase 1.1.1.21 0.839
1t41 ID5Aldose reductase 1.1.1.21 0.813
2pdm ZSTAldose reductase 1.1.1.21 0.797
2pdq 47DAldose reductase 1.1.1.21 0.794
2hv5 ZSTAldose reductase 1.1.1.21 0.785
1frb ZSTAldose reductase-related protein 2 / 0.781
2pd5 ZSTAldose reductase 1.1.1.21 0.777
2fz8 ZSTAldose reductase 1.1.1.21 0.771
2duz ZSTAldose reductase 1.1.1.21 0.768
2hvo ZSTAldose reductase 1.1.1.21 0.768
2hvn ZSTAldose reductase 1.1.1.21 0.763
2pdi ZSTAldose reductase 1.1.1.21 0.761
2dv0 ZSTAldose reductase 1.1.1.21 0.753
2pdb ZSTAldose reductase 1.1.1.21 0.749
2pdx ZSTAldose reductase 1.1.1.21 0.744
3m4h 388Aldose reductase 1.1.1.21 0.744
2pzn 393Aldose reductase 1.1.1.21 0.732
3ld5 LDTAldose reductase 1.1.1.21 0.730
3ght LDTAldose reductase 1.1.1.21 0.729
2pdu 393Aldose reductase 1.1.1.21 0.728
2pdp 393Aldose reductase 1.1.1.21 0.720
2pdc 393Aldose reductase 1.1.1.21 0.718
1iei ZESAldose reductase 1.1.1.21 0.715
3mc5 393Aldose reductase 1.1.1.21 0.714
3ghu LDTAldose reductase 1.1.1.21 0.713
3lz5 LDTAldose reductase 1.1.1.21 0.713
3len ZSTAldose reductase 1.1.1.21 0.711
3m64 393Aldose reductase 1.1.1.21 0.707
3m0i ZSTAldose reductase 1.1.1.21 0.696
3lql LDTAldose reductase 1.1.1.21 0.690
2ikj 393Aldose reductase 1.1.1.21 0.689
2pdf ZSTAldose reductase 1.1.1.21 0.685
3ghs LDTAldose reductase 1.1.1.21 0.652
3mb9 ZSTAldose reductase 1.1.1.21 0.651