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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fzp AGS Protein-tyrosine kinase 2-beta 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.871
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.714
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.709
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.694
4c3r ACPAurora kinase A 2.7.11.1 0.683
2ozo ANPTyrosine-protein kinase ZAP-70 2.7.10.2 0.676
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.676
2pzp ACPFibroblast growth factor receptor 2 / 0.674
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.674
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.673
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.672
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.671
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.671
5l8l ADPAurora kinase A 2.7.11.1 0.666
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.661
5l8j ADPAurora kinase A 2.7.11.1 0.658
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.657
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.657
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.654
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.654
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.653
2itx ANPEpidermal growth factor receptor 2.7.10.1 0.652
3ac1 KZITyrosine-protein kinase Lck 2.7.10.2 0.651
4dt8 ADNAPH(2'')-Id / 0.650