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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fyw XCF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fyw XCFDihydrofolate reductase 1.5.1.3 0.950
3fyv XCFDihydrofolate reductase 1.5.1.3 0.858
3frf XCFDihydrofolate reductase 1.5.1.3 0.806
3fy8 XCFDihydrofolate reductase 1.5.1.3 0.787
2w9g TOPDihydrofolate reductase 1.5.1.3 0.785
3m09 RARDihydrofolate reductase 1.5.1.3 0.778
3fy9 XCFDihydrofolate reductase 1.5.1.3 0.739
4elf 35IDihydrofolate reductase / 0.738
4fgh 0U6Dihydrofolate reductase 1.5.1.3 0.724
3m08 RARDihydrofolate reductase 1.5.1.3 0.721
3fl8 RARDihydrofolate reductase / 0.711
4g8z TOPDihydrofolate reductase 1.5.1.3 0.706
4elb 34SDihydrofolate reductase / 0.705
2w9h TOPDihydrofolate reductase 1.5.1.3 0.685
3fra I2HDihydrofolate reductase 1.5.1.3 0.679
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.668
1tdr MTXDihydrofolate reductase 1.5.1.3 0.664
4elb 34RDihydrofolate reductase / 0.657
1dra MTXDihydrofolate reductase 1.5.1.3 0.655
2znn S44Peroxisome proliferator-activated receptor alpha / 0.652
1dyr TOPDihydrofolate reductase 1.5.1.3 0.651
3dau MTXDihydrofolate reductase 1.5.1.3 0.650