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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fy9 XCF Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fy9 XCFDihydrofolate reductase 1.5.1.3 0.974
3fy8 XCFDihydrofolate reductase 1.5.1.3 0.911
3frf XCFDihydrofolate reductase 1.5.1.3 0.814
3fyv XCFDihydrofolate reductase 1.5.1.3 0.814
3m08 RARDihydrofolate reductase 1.5.1.3 0.763
3fyw XCFDihydrofolate reductase 1.5.1.3 0.739
2w9g TOPDihydrofolate reductase 1.5.1.3 0.728
3fra I2HDihydrofolate reductase 1.5.1.3 0.708
4g8z TOPDihydrofolate reductase 1.5.1.3 0.690
1dg5 TOPDihydrofolate reductase 1.5.1.3 0.665
3m09 RARDihydrofolate reductase 1.5.1.3 0.657