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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fre TOP Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fre TOPDihydrofolate reductase 1.5.1.3 1.062
3tq8 TOPDihydrofolate reductase / 0.859
4fgg 0U5Dihydrofolate reductase 1.5.1.3 0.849
3fyv XCFDihydrofolate reductase 1.5.1.3 0.797
2w9h TOPDihydrofolate reductase 1.5.1.3 0.765
3fl9 TOPDihydrofolate reductase / 0.722
2w9g TOPDihydrofolate reductase 1.5.1.3 0.707
1kmv LIIDihydrofolate reductase 1.5.1.3 0.680
4elb 34SDihydrofolate reductase / 0.678
3sru Q26Dihydrofolate reductase 1.5.1.3 0.672
4elb 34RDihydrofolate reductase / 0.672
3fl8 RARDihydrofolate reductase / 0.669
3m09 RARDihydrofolate reductase 1.5.1.3 0.666
4fgh 0U6Dihydrofolate reductase 1.5.1.3 0.663
4ele 31IDihydrofolate reductase / 0.661
1dyr TOPDihydrofolate reductase 1.5.1.3 0.659
3srw Q27Dihydrofolate reductase 1.5.1.3 0.657
3sqy Q11Dihydrofolate reductase 1.5.1.3 0.654
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.651