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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3fpz AHZ Thiamine thiazole synthase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3fpz AHZThiamine thiazole synthase / 1.147
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.966
3jsk AHZThiamine thiazole synthase / 0.822
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.773
4udq FAD5-(hydroxymethyl)furfural oxidase / 0.770
3cty FADProbable thioredoxin reductase / 0.766
1cc2 FADCholesterol oxidase 1.1.3.6 0.760
1cbo FADCholesterol oxidase 1.1.3.6 0.759
3b6d FAECholesterol oxidase 1.1.3.6 0.759
4u2s FDACholesterol oxidase 1.1.3.6 0.759
1b4v FADCholesterol oxidase 1.1.3.6 0.757
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.753
3cox FADCholesterol oxidase 1.1.3.6 0.746
3cnj FADCholesterol oxidase 1.1.3.6 0.744
1b8s FADCholesterol oxidase 1.1.3.6 0.743
1n4v FADCholesterol oxidase 1.1.3.6 0.743
3cgd FADCoenzyme A disulfide reductase / 0.739
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.737
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.733
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.732
4xwr FADCholesterol oxidase 1.1.3.6 0.730
1ijh FADCholesterol oxidase 1.1.3.6 0.729
1mxt FAECholesterol oxidase 1.1.3.6 0.729
1n1p FADCholesterol oxidase 1.1.3.6 0.729
1n4u FAECholesterol oxidase 1.1.3.6 0.729
1n4w FADCholesterol oxidase 1.1.3.6 0.729
2gew FADCholesterol oxidase 1.1.3.6 0.729
3cge FADCoenzyme A disulfide reductase / 0.729
3gyi FADCholesterol oxidase 1.1.3.6 0.729
3nlc FADUncharacterized protein / 0.729
4rek FADCholesterol oxidase 1.1.3.6 0.729
4u2t FADCholesterol oxidase 1.1.3.6 0.729
4xxg FADCholesterol oxidase 1.1.3.6 0.729
4z26 FADPutative GMC-type oxidoreductase R135 1 0.725
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.718
2eq7 NADDihydrolipoyl dehydrogenase / 0.717
3r9u FADThioredoxin reductase / 0.715
3cgc FADCoenzyme A disulfide reductase / 0.714
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.713
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.711
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.710
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.709
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.708
3lov FADProtoporphyrinogen oxidase / 0.703
2qa1 FADPgaE / 0.701
3ish FADThioredoxin reductase 1.8.1.9 0.699
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.698
2cul FADGidA-related protein / 0.698
2xve FADPutative flavin-containing monooxygenase / 0.698
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.697
3t37 FADPyridoxine 4-oxidase / 0.697
4emw FADCoenzyme A disulfide reductase / 0.697
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.695
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.694
4b69 FADL-ornithine N(5)-monooxygenase / 0.691
5hsa FASAlcohol oxidase 1 1.1.3.13 0.689
3k30 ADPHistamine dehydrogenase / 0.688
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.686
1y56 ATPUncharacterized protein / 0.682
4usr FADMonooxygenase / 0.682
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.680
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.680
4qi4 FADCellobiose dehydrogenase / 0.679
3up4 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.678
4qi5 FADCellobiose dehydrogenase / 0.673
4tm3 FADKtzI / 0.673
1npx FADNADH peroxidase 1.11.1.1 0.672
1v0j FADUDP-galactopyranose mutase 5.4.99.9 0.672
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.672
4qi7 FADCellobiose dehydrogenase / 0.672
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.670
3atr FDAConserved Archaeal protein / 0.670
3atq FDAConserved Archaeal protein / 0.669
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.669
1qo8 FADFumarate reductase flavoprotein subunit / 0.668
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.668
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.667
3t2y FADSulfide-quinone reductase / 0.666
2rdn 1PL1-deoxypentalenic acid 11-beta-hydroxylase 1.14.11.35 0.664
2b9y FADPutative aminooxidase / 0.663
2x3n FADProbable FAD-dependent monooxygenase / 0.663
4j34 FADKynurenine 3-monooxygenase / 0.663
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.662
3gyj FADCholesterol oxidase 1.1.3.6 0.660
3s5w FADL-ornithine N(5)-monooxygenase / 0.660
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.659
3a27 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.659
4bjz FADProbable salicylate monooxygenase / 0.659
4c3y FAD3-ketosteroid dehydrogenase / 0.659
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.659
1kf6 FADFumarate reductase flavoprotein subunit 1.3.5.4 0.658
1tdf FADThioredoxin reductase 1.8.1.9 0.658
2q0k FADThioredoxin reductase 1.8.1.9 0.658
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.658
4opl FDAConserved Archaeal protein / 0.658
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.658
3gd3 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.657
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.657
2npx FADNADH peroxidase 1.11.1.1 0.655
1nhq FADNADH peroxidase 1.11.1.1 0.654
2e1m FADL-glutamate oxidase / 0.654
3int FDAUDP-galactopyranose mutase 5.4.99.9 0.654
4opc FDAConserved Archaeal protein / 0.654
1zx9 FADMercuric reductase 1.16.1.1 0.653
2vqb FADPutative flavin-containing monooxygenase / 0.653
3nix FADFlavoprotein/dehydrogenase / 0.653
2aqj FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.652
4nwz FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.652
4opg FDAConserved Archaeal protein / 0.652
3sz0 FADSulfide-quinone reductase / 0.651
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.651
3utf FDAUDP-galactopyranose mutase / 0.651
2rgh FADAlpha-Glycerophosphate Oxidase / 0.650
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.650
3f8p NADNADH oxidase/thioredoxin reductase / 0.650
3g07 SAM7SK snRNA methylphosphate capping enzyme 2.1.1 0.650
3lad FADDihydrolipoyl dehydrogenase / 0.650