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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3f5p 741 Insulin-like growth factor 1 receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3f5p 741Insulin-like growth factor 1 receptor 2.7.10.1 1.119
2ivu ZD6Proto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.763
5amn DTQProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.756
3b8r 887Vascular endothelial growth factor receptor 2 2.7.10.1 0.755
4ase AV9Vascular endothelial growth factor receptor 2 2.7.10.1 0.741
4i23 1C9Epidermal growth factor receptor 2.7.10.1 0.738
4i22 IREEpidermal growth factor receptor 2.7.10.1 0.721
4qmn DB8Serine/threonine-protein kinase 24 2.7.11.1 0.680
5ajq DB8Serine/threonine-protein kinase 10 2.7.11.1 0.680
3dok GWJPol protein / 0.671
5bvw 1N1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.671
4kbc 1QJCasein kinase I isoform delta 2.7.11.1 0.664
4hjo AQ4Epidermal growth factor receptor 2.7.10.1 0.663
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.659
2xir 00JVascular endothelial growth factor receptor 2 2.7.10.1 0.659
4qmx H8HSerine/threonine-protein kinase 24 2.7.11.1 0.656
3dmj GWEPol protein / 0.655
2itz IREEpidermal growth factor receptor 2.7.10.1 0.654
4fv7 E94Mitogen-activated protein kinase 1 2.7.11.24 0.654
1yol S03Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.653