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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eqm ASD Aromatase 1.14.14.14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3eqm ASDAromatase 1.14.14.14 1.075
3s79 ASDAromatase 1.14.14.14 1.069
3cot STR3-oxo-5-beta-steroid 4-dehydrogenase / 0.704
2aa6 STRMineralocorticoid receptor / 0.701
4nky 3QZSteroid 17-alpha-hydroxylase/17,20 lyase / 0.694
1kdk DHTSex hormone-binding globulin / 0.693
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.689
2aa5 STRMineralocorticoid receptor / 0.686
1kdm DHTSex hormone-binding globulin / 0.684
1ya3 STRMineralocorticoid receptor / 0.680
1y5r C0RCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.677
4p6x HCYGlucocorticoid receptor / 0.675
2cbo TH2Neocarzinostatin / 0.672
2ylo TESAndrogen receptor / 0.669
2b01 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.668
1f5f DHTSex hormone-binding globulin / 0.663
4bcs BTNAvidin-related protein 4/5 / 0.663
4klr CHDFerrochelatase, mitochondrial 4.99.1.1 0.663
2rlc CHDCholoylglycine hydrolase 3.5.1.24 0.662
1d2s DHTSex hormone-binding globulin / 0.661
4uda DEXMineralocorticoid receptor / 0.661
4udc DEXGlucocorticoid receptor / 0.660
1lhv NOGSex hormone-binding globulin / 0.658
1zhw HC2Oxysterol-binding protein homolog 4 / 0.657
4k7a DHTAndrogen receptor / 0.656
2aba STRPentaerythritol tetranitrate reductase / 0.653
3mnp DEXGlucocorticoid receptor / 0.653
2b1z 17MEstrogen receptor / 0.651
1lnm DTXBilin-binding protein / 0.650
3w1w CHDFerrochelatase, mitochondrial 4.99.1.1 0.650
4j26 ESTEstrogen receptor beta / 0.650