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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3el8 PD5 Proto-oncogene tyrosine-protein kinase Src 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 1.188
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.768
3el7 PD3Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.765
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.745
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.745
3qlf PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.727
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.719
3gcs BAXMitogen-activated protein kinase 14 / 0.706
3vhe 42QVascular endothelial growth factor receptor 2 2.7.10.1 0.703
3ugc 046Tyrosine-protein kinase JAK2 / 0.701
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.692
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.687
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.680
4neu Q1AReceptor-interacting serine/threonine-protein kinase 1 2.7.11.1 0.680
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.672
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.671
2rl5 2RLVascular endothelial growth factor receptor 2 2.7.10.1 0.662
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.662
3gi3 B10Mitogen-activated protein kinase 14 / 0.661
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.654
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.653
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.652
2xhx T5MHeat shock protein HSP 90-alpha / 0.652