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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3eko PYU Heat shock protein HSP 90-alpha

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3eko PYUHeat shock protein HSP 90-alpha / 0.834
2yi5 YI5Heat shock protein HSP 90-alpha / 0.800
4bqj XKLHeat shock protein HSP 90-alpha / 0.797
4b7p 9UNHeat shock protein HSP 90-alpha / 0.790
4egk RDCHeat shock protein HSP 90-alpha / 0.788
2yk2 YJWHeat shock protein HSP 90-alpha / 0.782
2ye4 2FYHeat shock protein HSP 90-alpha / 0.775
2yi6 6QMHeat shock protein HSP 90-alpha / 0.775
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.772
2xjj L81Heat shock protein HSP 90-alpha / 0.766
2xx2 13CATP-dependent molecular chaperone HSP82 / 0.760
2yjw YJWHeat shock protein HSP 90-alpha / 0.759
3k97 4CDHeat shock protein HSP 90-alpha / 0.754
3k98 1RCHeat shock protein HSP 90-alpha / 0.753
2xab VHDHeat shock protein HSP 90-alpha / 0.750
2xjx XJXHeat shock protein HSP 90-alpha / 0.750
2yi7 BZ8Heat shock protein HSP 90-alpha / 0.748
3k99 PFTHeat shock protein HSP 90-alpha / 0.746
3hek BD0Heat shock protein HSP 90-alpha / 0.745
3ekr PY9Heat shock protein HSP 90-alpha / 0.744
4e5i 0N9Polymerase acidic protein / 0.744
1yc1 4BCHeat shock protein HSP 90-alpha / 0.738
2byi 2DDHeat shock protein HSP 90-alpha / 0.737
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.736
2ccu 2D9Heat shock protein HSP 90-alpha / 0.735
1yc4 43PHeat shock protein HSP 90-alpha / 0.734
2xx5 13NATP-dependent molecular chaperone HSP82 / 0.734
1qy8 RDIEndoplasmin / 0.729
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.729
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.728
1u0z RDCEndoplasmin / 0.724
3hhu 819Heat shock protein HSP 90-alpha / 0.724
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.715
3inx JZCHeat shock protein HSP 90-alpha / 0.710
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.709
2vci 2GJHeat shock protein HSP 90-alpha / 0.708
2xht C0YHeat shock protein HSP 90-alpha / 0.706
4egh 0OYHeat shock protein HSP 90-alpha / 0.706
2gfd RDAEndoplasmin / 0.688
2wer RDCATP-dependent molecular chaperone HSP82 / 0.685
2bre KJ2ATP-dependent molecular chaperone HSP82 / 0.684
2brc CT5ATP-dependent molecular chaperone HSP82 / 0.681
2yec XQ0Heat shock protein HSP 90-alpha / 0.669
2fxs RDAATP-dependent molecular chaperone HSP82 / 0.667
2fyp RDEEndoplasmin / 0.665
4mpn PV0[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1m78 CLZDihydrofolate reductase 1.5.1.3 0.659
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 0.655
1yy4 4NAEstrogen receptor beta / 0.651