Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3duf R1T Pyruvate dehydrogenase E1 component subunit alpha 1.2.4.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3duf R1TPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 1.215
3duf R1TPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 1.215
3dv0 TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.954
3dv0 TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.954
2j9f THV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.864
2j9f THV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial 1.2.4.4 0.864
1v11 TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.828
3exh TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.818
3exh TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.818
1ols TDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 1.2.4.4 0.813
1ni4 TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.803
1ni4 TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.803
3zhu TD8Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.767
1umc TDP2-oxoisovalerate dehydrogenase subunit alpha 1.2.4.4 0.765
1umc TDP2-oxoisovalerate dehydrogenase subunit beta 1.2.4.4 0.765
3exf TPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1.2.4.1 0.761
3exf TPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial 1.2.4.1 0.761
3dva TPWPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.756
3dva TPWPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.756
3zhs TD6Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.746
2qtc TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.719
1y9d TPPPyruvate oxidase 1.2.3.3 0.712
3zht TD9Multifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.711
1l8a TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.709
4qel TZDBenzoylformate decarboxylase 4.1.1.7 0.708
3zhr TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.706
2q5q TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.705
1po7 TZDBenzoylformate decarboxylase 4.1.1.7 0.703
2g28 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.701
5ej4 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.700
3zhv TDWMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.699
5ej7 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.697
1pox TPPPyruvate oxidase 1.2.3.3 0.696
2fwn TDPBenzoylformate decarboxylase 4.1.1.7 0.695
2q5o TPWIndole-3-pyruvate decarboxylase 4.1.1.74 0.692
4ju8 TZDBenzoylformate decarboxylase 4.1.1.7 0.691
4ju9 TZDBenzoylformate decarboxylase 4.1.1.7 0.691
2qta TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.690
3d7k D7KBenzaldehyde lyase / 0.690
4k9n TZDBenzoylformate decarboxylase 4.1.1.7 0.688
4mpr TPPBenzoylformate decarboxylase 4.1.1.7 0.688
5dgt TZDBenzoylformate decarboxylase 4.1.1.7 0.688
1gpu THDTransketolase 1 2.2.1.1 0.687
2o1x TDP1-deoxy-D-xylulose-5-phosphate synthase 2.2.1.7 0.686
2g25 TDKPyruvate dehydrogenase E1 component 1.2.4.1 0.685
5eja TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.684
1trk TPPTransketolase 1 2.2.1.1 0.682
3fzn D7KBenzoylformate decarboxylase 4.1.1.7 0.682
4mq5 TPPBenzoylformate decarboxylase 4.1.1.7 0.682
5ej9 TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.682
2r8o T5XTransketolase 1 / 0.681
3fsj D7KBenzoylformate decarboxylase 4.1.1.7 0.680
3zhq TPPMultifunctional 2-oxoglutarate metabolism enzyme 1.2.4.2 0.679
4jub TPPBenzoylformate decarboxylase 4.1.1.7 0.679
2uz1 TPPBenzaldehyde lyase / 0.678
4k9o TPPBenzoylformate decarboxylase 4.1.1.7 0.677
2ezt TDMPyruvate oxidase 1.2.3.3 0.676
5ahk TPPAcetolactate synthase II, large subunit / 0.676
5esd TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.675
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.674
2r5n TPPTransketolase 1 / 0.674
2v3w TPPBenzoylformate decarboxylase 4.1.1.7 0.674
3ey9 TDPPyruvate dehydrogenase [ubiquinone] 1.2.5.1 0.674
1bfd TPPBenzoylformate decarboxylase 4.1.1.7 0.672
3upt TPPTransketolase / 0.671
4gm4 TZDBenzoylformate decarboxylase 4.1.1.7 0.671
1mcz TDPBenzoylformate decarboxylase 4.1.1.7 0.670
3ahi HTLProbable phosphoketolase / 0.669
1tkc M6TTransketolase 1 2.2.1.1 0.668
4mzx TZDBenzoylformate decarboxylase 4.1.1.7 0.668
3m34 TPPTransketolase / 0.667
4k9p TPPBenzoylformate decarboxylase 4.1.1.7 0.667
5eso TDP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.667
2pan TDPGlyoxylate carboligase 4.1.1.47 0.666
5ej8 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.666
2ez9 TDKPyruvate oxidase 1.2.3.3 0.665
1ay0 TPPTransketolase 1 2.2.1.1 0.663
3ahj TPPProbable phosphoketolase / 0.662
4gg1 TZDBenzoylformate decarboxylase 4.1.1.7 0.662
1rp7 TZDPyruvate dehydrogenase E1 component 1.2.4.1 0.661
4jd5 TZDBenzoylformate decarboxylase 4.1.1.7 0.661
3oe1 TDLPyruvate decarboxylase 4.1.1.1 0.660
1w88 TDPPyruvate dehydrogenase E1 component subunit alpha 1.2.4.1 0.658
1w88 TDPPyruvate dehydrogenase E1 component subunit beta 1.2.4.1 0.658
2r8p T6FTransketolase 1 / 0.657
3m7i TPPTransketolase / 0.657
4juc TPPBenzoylformate decarboxylase 4.1.1.7 0.657
2c31 TZDOxalyl-CoA decarboxylase 4.1.1.8 0.656
2jla TPP2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.656
4gm1 TZDBenzoylformate decarboxylase 4.1.1.7 0.656
2iea TDPPyruvate dehydrogenase E1 component 1.2.4.1 0.655
2ag0 TPPBenzaldehyde lyase / 0.654
4mpp TZDBenzoylformate decarboxylase 4.1.1.7 0.654
5ej5 TD62-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase / 0.651