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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3drc MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3drc MTXDihydrofolate reductase 1.5.1.3 1.099
3och 2MXDihydrofolate reductase 1.5.1.3 1.053
2drc MTXDihydrofolate reductase 1.5.1.3 1.037
1dra MTXDihydrofolate reductase 1.5.1.3 1.022
4dfr MTXDihydrofolate reductase 1.5.1.3 1.020
5hi6 MTXDihydrofolate reductase / 0.986
1dhi MTXDihydrofolate reductase 1.5.1.3 0.981
3dau MTXDihydrofolate reductase 1.5.1.3 0.965
1dhj MTXDihydrofolate reductase 1.5.1.3 0.960
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.950
1drb MTXDihydrofolate reductase 1.5.1.3 0.946
1df7 MTXDihydrofolate reductase 1.5.1.3 0.922
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.917
3ia4 MTXDihydrofolate reductase / 0.900
1tdr MTXDihydrofolate reductase 1.5.1.3 0.892
4p66 MTXDihydrofolate reductase / 0.891
4qi9 MTXDihydrofolate reductase / 0.884
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.874
2qk8 MTXDihydrofolate reductase / 0.869
3tq9 MTXDihydrofolate reductase / 0.864
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.859
3eig MTXDihydrofolate reductase 1.5.1.3 0.852
1dre MTXDihydrofolate reductase 1.5.1.3 0.851
1dls MTXDihydrofolate reductase 1.5.1.3 0.849
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.831
1u70 MTXDihydrofolate reductase 1.5.1.3 0.813
1dyj DDFDihydrofolate reductase 1.5.1.3 0.810
1u72 MTXDihydrofolate reductase 1.5.1.3 0.801
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.799
1jol FFODihydrofolate reductase 1.5.1.3 0.794
4i1n FOLDihydrofolate reductase 1.5.1.3 0.786
2zza FOLDihydrofolate reductase / 0.785
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.784
3dat MTXDihydrofolate reductase / 0.783
4x5f FOLDihydrofolate reductase 1.5.1.3 0.779
1e26 GPBDihydrofolate reductase 1.5.1.3 0.774
4p68 MTXDihydrofolate reductase / 0.772
1ddr MTXDihydrofolate reductase 1.5.1.3 0.771
1hfr MOTDihydrofolate reductase 1.5.1.3 0.764
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.764
1dyi FOLDihydrofolate reductase 1.5.1.3 0.759
1jom FFODihydrofolate reductase 1.5.1.3 0.758
3dfr MTXDihydrofolate reductase 1.5.1.3 0.757
4x5g FOLDihydrofolate reductase 1.5.1.3 0.757
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.754
1dyh DZFDihydrofolate reductase 1.5.1.3 0.753
1ohj COPDihydrofolate reductase 1.5.1.3 0.753
4x5i FOLDihydrofolate reductase 1.5.1.3 0.751
5ccc DDFDihydrofolate reductase 1.5.1.3 0.751
3frd DHFDihydrofolate reductase 1.5.1.3 0.745
1hfq MOTDihydrofolate reductase 1.5.1.3 0.744
1hfp MOTDihydrofolate reductase 1.5.1.3 0.743
1dds MTXDihydrofolate reductase 1.5.1.3 0.742
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.738
1re7 FOLDihydrofolate reductase 1.5.1.3 0.737
3ghv GHCDihydrofolate reductase 1.5.1.3 0.735
1drf FOLDihydrofolate reductase 1.5.1.3 0.733
4i13 FOLDihydrofolate reductase 1.5.1.3 0.732
2w3m FOLDihydrofolate reductase 1.5.1.3 0.731
4m6k FOLDihydrofolate reductase 1.5.1.3 0.730
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.728
2d0k FOLDihydrofolate reductase 1.5.1.3 0.722
4x5h FOLDihydrofolate reductase 1.5.1.3 0.720
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.718
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.712
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.712
4keb FOLDihydrofolate reductase 1.5.1.3 0.712
4kfj FOLDihydrofolate reductase 1.5.1.3 0.712
7dfr FOLDihydrofolate reductase 1.5.1.3 0.712
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.711
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.711
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.708
1ohk COPDihydrofolate reductase 1.5.1.3 0.706
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.705
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.702
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.699
4m6l 21VDihydrofolate reductase 1.5.1.3 0.695
1dhf FOLDihydrofolate reductase 1.5.1.3 0.693
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.691
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.687
3td8 D2RDihydrofolate reductase 1.5.1.3 0.681
4fhb FOLDihydrofolate reductase 1.5.1.3 0.681
3ghw GHWDihydrofolate reductase 1.5.1.3 0.680
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.678
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.673
1daj MOTDihydrofolate reductase 1.5.1.3 0.672
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.672
1dg5 TOPDihydrofolate reductase 1.5.1.3 0.671
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.671
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.669
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.668
4kjj FOLDihydrofolate reductase 1.5.1.3 0.667
2vbp VB1Isopenicillin N synthase 1.21.3.1 0.664
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.661
2dhf DZFDihydrofolate reductase 1.5.1.3 0.660
3tqb FOLDihydrofolate reductase / 0.660
4nhm UN9Prolyl 3,4-dihydroxylase TPA1 1.14.11 0.660
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.659
4bqs K2QShikimate kinase 2.7.1.71 0.658
1dyr TOPDihydrofolate reductase 1.5.1.3 0.657
1qiq ACCIsopenicillin N synthase 1.21.3.1 0.656
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.654