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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dko IHZ Ephrin type-A receptor 7 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dko IHZEphrin type-A receptor 7 2.7.10.1 1.166
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.736
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.729
4kao KAOFocal adhesion kinase 1 2.7.10.2 0.703
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.699
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.697
4agw NG7Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.690
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.689
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.688
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.685
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.682
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.682
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.680
3el8 PD5Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.680
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.676
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.674
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.672
2p4i MR9Angiopoietin-1 receptor 2.7.10.1 0.670
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.670
3ugc 046Tyrosine-protein kinase JAK2 / 0.664
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.660
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.659
3iw5 DF3Mitogen-activated protein kinase 14 / 0.657