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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dfc ANP Death-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 1.134
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.904
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.871
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.854
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.835
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.827
3llt ANPProtein serine/threonine kinase-1 / 0.814
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.799
2pyw ADPMethylthioribose kinase 2.7.1.100 0.798
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.798
2pui ADPMethylthioribose kinase 2.7.1.100 0.795
3oro AGSSerine/threonine protein kinase / 0.793
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.792
3ori AGSSerine/threonine protein kinase / 0.787
3ort AGSSerine/threonine protein kinase / 0.786
3nie ANPMitogen-activated protein kinase / 0.785
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.784
2olc ADPMethylthioribose kinase 2.7.1.100 0.781
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.780
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.776
4ceg ADPAurora kinase A 2.7.11.1 0.773
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.770
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.769
3c4z ADPRhodopsin kinase / 0.764
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.758
1mq4 ADPAurora kinase A 2.7.11.1 0.757
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.757
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.756
2pul ACPMethylthioribose kinase 2.7.1.100 0.754
3qc9 ADPRhodopsin kinase / 0.754
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.753
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.750
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.750
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.750
5dos ATPAurora kinase A 2.7.11.1 0.750
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
5dt3 ATPAurora kinase A 2.7.11.1 0.748
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.745
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.745
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.744
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
3t8o ATPRhodopsin kinase / 0.739
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.738
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
5drd ATPAurora kinase A 2.7.11.1 0.735
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.731
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.729
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.728
2p0a ANPSynapsin-3 / 0.727
4xlv ACPInsulin receptor 2.7.10.1 0.726
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.724
5dr2 ATPAurora kinase A 2.7.11.1 0.724
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.721
5dn3 ATPAurora kinase A 2.7.11.1 0.721
5dnr ATPAurora kinase A 2.7.11.1 0.721
5dt4 ATPAurora kinase A 2.7.11.1 0.720
3orm AGSSerine/threonine protein kinase / 0.719
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.719
3c4w ATPRhodopsin kinase / 0.718
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.718
4o4d ATPKinase / 0.717
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
4ysj ADPCalmodulin-like domain protein kinase / 0.716
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.715
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.714
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.713
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.711
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.711
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.710
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.710
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.709
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.708
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.705
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.705
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.704
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.704
3bu5 ATPInsulin receptor 2.7.10.1 0.704
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.704
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.703
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.699
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.699
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.699
4utd ACPAurora kinase A 2.7.11.1 0.698
4zgn ATPCell division cycle protein 123 / 0.698
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
5iqb GNPBifunctional AAC/APH 2.3.1 0.695
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.693
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.692
4qny ANPMitogen activated protein kinase, putative / 0.692
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
5iqf GDPBifunctional AAC/APH 2.3.1 0.692
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.691
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
4n57 ADPAPH(2'')-Id / 0.691
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.691
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4dee ADPAurora kinase A 2.7.11.1 0.690
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.689
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.688
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.688
5eg3 ACPFibroblast growth factor receptor 2 / 0.688
4c3r ACPAurora kinase A 2.7.11.1 0.687
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.686
2yaa ATPDeath-associated protein kinase 2 / 0.685
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.685
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.685
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.683
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.683
2dwb ANPAurora kinase A 2.7.11.1 0.682
3tdw GDPGentamicin resistance protein / 0.682
2pun ACPMethylthioribose kinase 2.7.1.100 0.681
3orp AGSSerine/threonine protein kinase / 0.681
5l8k ADPAurora kinase A 2.7.11.1 0.680
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.679
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.677
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.677
1cm8 ANPMitogen-activated protein kinase 12 / 0.675
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.675
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.675
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.675
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.675
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.674
4bn1 ADPAurora kinase A 2.7.11.1 0.673
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.672
1u54 ACPActivated CDC42 kinase 1 / 0.671
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.671
2pup ADPMethylthioribose kinase 2.7.1.100 0.671
5l8j ADPAurora kinase A 2.7.11.1 0.671
4jrn ANPRhoptry kinase family protein / 0.670
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.669
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.669
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.668
2vqd AP2Biotin carboxylase 6.3.4.14 0.667
4gv1 0XZRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.667
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.667
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.666
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.666
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.666
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
1bmf ADPATP synthase subunit alpha, mitochondrial / 0.665
1bmf ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.665
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.665
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.665
3r5f ATPD-alanine--D-alanine ligase / 0.664
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.662
4c3p ACPAurora kinase A 2.7.11.1 0.662
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.662
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.661
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.661
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.660
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.660
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.660
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.659
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.659
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.658
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.658
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.658
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.657
1ol5 ADPAurora kinase A 2.7.11.1 0.656
2pml ANPUncharacterized protein / 0.656
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.656
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.656
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.656
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.656
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.655
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.655
1ol6 ATPAurora kinase A 2.7.11.1 0.654
3q5i ANPProtein kinase, putative / 0.654
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.654
4eyf PNKMetallo-beta-lactamase type 2 / 0.654
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.654
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.653
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.652
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.651
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.650
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.650