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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ddp RC8 Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3ddp RC8Cyclin-dependent kinase 2 2.7.11.22 1.001
3ddq RRCCyclin-dependent kinase 2 2.7.11.22 0.879
1unl RRCCyclin-dependent-like kinase 5 2.7.11.1 0.814
3dog NNNCyclin-dependent kinase 2 2.7.11.22 0.786
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2a4l RRCCyclin-dependent kinase 2 2.7.11.22 0.740
3pj8 404Cyclin-dependent kinase 2 2.7.11.22 0.721
4kd1 1QKCyclin-dependent kinase 2 2.7.11.22 0.702
2wpa 889Cyclin-dependent kinase 2 2.7.11.22 0.693
2r3m SCXCyclin-dependent kinase 2 2.7.11.22 0.692
2f2c AP9Cyclin-dependent kinase 6 2.7.11.22 0.683
3lq5 SLQCyclin-dependent kinase 9 2.7.11.22 0.677
2a0c CK9Cyclin-dependent kinase 2 2.7.11.22 0.675
2cdz 23DSerine/threonine-protein kinase PAK 4 2.7.11.1 0.674
2r3l SCWCyclin-dependent kinase 2 2.7.11.22 0.667
1y91 CT9Cyclin-dependent kinase 2 2.7.11.22 0.666
1vyw 292Cyclin-dependent kinase 2 2.7.11.22 0.663
2izt 23DCasein kinase I isoform gamma-3 2.7.11.1 0.663
4e5f 0N7Polymerase acidic protein / 0.660
1v0p PVBCell division control protein 2 homolog 2.7.11.22 0.657
2r3r 6SCCyclin-dependent kinase 2 2.7.11.22 0.657
2r3o 2SCCyclin-dependent kinase 2 2.7.11.22 0.653