Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dau MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3dau MTXDihydrofolate reductase 1.5.1.3 1.150
3drc MTXDihydrofolate reductase 1.5.1.3 0.965
3och 2MXDihydrofolate reductase 1.5.1.3 0.963
1dra MTXDihydrofolate reductase 1.5.1.3 0.946
2drc MTXDihydrofolate reductase 1.5.1.3 0.931
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.930
4dfr MTXDihydrofolate reductase 1.5.1.3 0.924
1dls MTXDihydrofolate reductase 1.5.1.3 0.918
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.918
5hi6 MTXDihydrofolate reductase / 0.913
4p66 MTXDihydrofolate reductase / 0.911
1df7 MTXDihydrofolate reductase 1.5.1.3 0.908
3ia4 MTXDihydrofolate reductase / 0.904
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.887
3tq9 MTXDihydrofolate reductase / 0.878
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.866
2qk8 MTXDihydrofolate reductase / 0.860
3eig MTXDihydrofolate reductase 1.5.1.3 0.857
1tdr MTXDihydrofolate reductase 1.5.1.3 0.856
1dhj MTXDihydrofolate reductase 1.5.1.3 0.854
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.853
1jol FFODihydrofolate reductase 1.5.1.3 0.844
1dre MTXDihydrofolate reductase 1.5.1.3 0.843
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.830
2zza FOLDihydrofolate reductase / 0.830
3cd2 MTXDihydrofolate reductase 1.5.1.3 0.817
1u70 MTXDihydrofolate reductase 1.5.1.3 0.807
1u72 MTXDihydrofolate reductase 1.5.1.3 0.799
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.797
4m6k FOLDihydrofolate reductase 1.5.1.3 0.793
1dhi MTXDihydrofolate reductase 1.5.1.3 0.791
3dfr MTXDihydrofolate reductase 1.5.1.3 0.790
1dyj DDFDihydrofolate reductase 1.5.1.3 0.789
1hfq MOTDihydrofolate reductase 1.5.1.3 0.789
4keb FOLDihydrofolate reductase 1.5.1.3 0.786
4qi9 MTXDihydrofolate reductase / 0.786
4i1n FOLDihydrofolate reductase 1.5.1.3 0.783
1drb MTXDihydrofolate reductase 1.5.1.3 0.781
1drf FOLDihydrofolate reductase 1.5.1.3 0.777
1hfp MOTDihydrofolate reductase 1.5.1.3 0.777
1ohj COPDihydrofolate reductase 1.5.1.3 0.771
4kjj FOLDihydrofolate reductase 1.5.1.3 0.771
4x5i FOLDihydrofolate reductase 1.5.1.3 0.761
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.759
7dfr FOLDihydrofolate reductase 1.5.1.3 0.758
1e26 GPBDihydrofolate reductase 1.5.1.3 0.757
1jom FFODihydrofolate reductase 1.5.1.3 0.755
4p68 MTXDihydrofolate reductase / 0.755
1hfr MOTDihydrofolate reductase 1.5.1.3 0.754
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.754
4kfj FOLDihydrofolate reductase 1.5.1.3 0.751
3dat MTXDihydrofolate reductase / 0.746
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.745
4i13 FOLDihydrofolate reductase 1.5.1.3 0.745
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.738
4fhb FOLDihydrofolate reductase 1.5.1.3 0.738
4x5f FOLDihydrofolate reductase 1.5.1.3 0.737
4x5h FOLDihydrofolate reductase 1.5.1.3 0.737
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.736
3frd DHFDihydrofolate reductase 1.5.1.3 0.736
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.736
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.734
1dyi FOLDihydrofolate reductase 1.5.1.3 0.730
2w3m FOLDihydrofolate reductase 1.5.1.3 0.730
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.730
1dyh DZFDihydrofolate reductase 1.5.1.3 0.729
5ccc DDFDihydrofolate reductase 1.5.1.3 0.728
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.724
1dds MTXDihydrofolate reductase 1.5.1.3 0.721
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.719
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.718
2dhf DZFDihydrofolate reductase 1.5.1.3 0.712
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.709
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.706
3tqb FOLDihydrofolate reductase / 0.704
1ddr MTXDihydrofolate reductase 1.5.1.3 0.700
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.700
1ohk COPDihydrofolate reductase 1.5.1.3 0.696
2d0k FOLDihydrofolate reductase 1.5.1.3 0.692
1re7 FOLDihydrofolate reductase 1.5.1.3 0.691
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.690
4x5g FOLDihydrofolate reductase 1.5.1.3 0.690
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.689
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.687
4m6l 21VDihydrofolate reductase 1.5.1.3 0.687
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.684
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.683
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.682
1hbn TP7Methyl-coenzyme M reductase I subunit alpha 2.8.4.1 0.677
1hbn TP7Methyl-coenzyme M reductase I subunit beta 2.8.4.1 0.677
1daj MOTDihydrofolate reductase 1.5.1.3 0.671
3ghw GHWDihydrofolate reductase 1.5.1.3 0.669
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.667
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.664
1dhf FOLDihydrofolate reductase 1.5.1.3 0.660
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.659
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.657
1toi HCIAspartate aminotransferase 2.6.1.1 0.650
3jw5 TOPDihydrofolate reductase / 0.650
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.650