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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3d80 Q22 Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.675
1kmv LIIDihydrofolate reductase 1.5.1.3 0.669
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.668
3eek 53SUncharacterized protein / 0.667
4dfr MTXDihydrofolate reductase 1.5.1.3 0.667
2w3w VG9Dihydrofolate reductase / 0.666
3cse N22Uncharacterized protein / 0.666
4dph P65Bifunctional dihydrofolate reductase-thymidylate synthase / 0.666
4kak 06UDihydrofolate reductase 1.5.1.3 0.666
4p68 MTXDihydrofolate reductase / 0.666
1ia2 TQ4Dihydrofolate reductase 1.5.1.3 0.665
1mvs DTMDihydrofolate reductase 1.5.1.3 0.665
3eem 53VUncharacterized protein / 0.665
3s7a 684Dihydrofolate reductase 1.5.1.3 0.665
1dls MTXDihydrofolate reductase 1.5.1.3 0.664
1kms LIHDihydrofolate reductase 1.5.1.3 0.664
3dfr MTXDihydrofolate reductase 1.5.1.3 0.664
3ia4 MTXDihydrofolate reductase / 0.664
4ixg IXGDihydrofolate reductase 1.5.1.3 0.664
3eel 53TUncharacterized protein / 0.663
1m7a MQUDihydrofolate reductase 1.5.1.3 0.662
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.662
3jsu KA5Bifunctional dihydrofolate reductase-thymidylate synthase / 0.662
3jwc EKBDihydrofolate reductase / 0.662
3sai 9DRDihydrofolate reductase / 0.662
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.661
1dds MTXDihydrofolate reductase 1.5.1.3 0.661
1dyr TOPDihydrofolate reductase 1.5.1.3 0.661
1u70 MTXDihydrofolate reductase 1.5.1.3 0.661
3drc MTXDihydrofolate reductase 1.5.1.3 0.661
3eig MTXDihydrofolate reductase 1.5.1.3 0.661
3qlr QLRDihydrofolate reductase 1.5.1.3 0.661
3qlx QLRUncharacterized protein / 0.661
4ixf IXFDihydrofolate reductase 1.5.1.3 0.661
1klk PMDDihydrofolate reductase 1.5.1.3 0.660
1pd8 CO4Dihydrofolate reductase 1.5.1.3 0.660
1pd9 CO4Dihydrofolate reductase 1.5.1.3 0.660
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.660
1ia1 TQ3Dihydrofolate reductase 1.5.1.3 0.659
3i8a N22Dihydrofolate reductase 1.5.1.3 0.659
3qlz QLZUncharacterized protein / 0.659
1boz PRDDihydrofolate reductase 1.5.1.3 0.658
1dra MTXDihydrofolate reductase 1.5.1.3 0.658
1ia4 TQ6Dihydrofolate reductase 1.5.1.3 0.658
3qls 55VDihydrofolate reductase 1.5.1.3 0.658
4qi9 MTXDihydrofolate reductase / 0.658
1s3w TQTDihydrofolate reductase 1.5.1.3 0.657
2drc MTXDihydrofolate reductase 1.5.1.3 0.657
4dp3 MMVBifunctional dihydrofolate reductase-thymidylate synthase / 0.657
4m7v RARDihydrofolate reductase / 0.657
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.656
3fl8 RARDihydrofolate reductase / 0.656
3jw5 TOPDihydrofolate reductase / 0.656
3jwm 5WBDihydrofolate reductase / 0.656
3k45 51PDihydrofolate reductase 1.5.1.3 0.656
3kjs DQ1Bifunctional dihydrofolate reductase-thymidylate synthase / 0.656
3qyo Q24Dihydrofolate reductase 1.5.1.3 0.656
3r33 6MEDihydrofolate reductase 1.5.1.3 0.656
1hfp MOTDihydrofolate reductase 1.5.1.3 0.655
1s3v TQDDihydrofolate reductase 1.5.1.3 0.655
4elf 35IDihydrofolate reductase / 0.655
5hi6 MTXDihydrofolate reductase / 0.655
1hfr MOTDihydrofolate reductase 1.5.1.3 0.654
1ly4 COQDihydrofolate reductase 1.5.1.3 0.654
4elh 53IDihydrofolate reductase / 0.654
1dlr MXADihydrofolate reductase 1.5.1.3 0.653
1m79 MQ1Dihydrofolate reductase 1.5.1.3 0.653
3eej 53RUncharacterized protein / 0.653
4ddr MMVDihydrofolate reductase 1.5.1.3 0.653
4h98 14QUncharacterized protein / 0.653
1dre MTXDihydrofolate reductase 1.5.1.3 0.652
1m78 CLZDihydrofolate reductase 1.5.1.3 0.652
3dat MTXDihydrofolate reductase / 0.652
1hfq MOTDihydrofolate reductase 1.5.1.3 0.651
1ia3 TQ5Dihydrofolate reductase 1.5.1.3 0.651
3fre TOPDihydrofolate reductase 1.5.1.3 0.651
1u71 MXADihydrofolate reductase 1.5.1.3 0.650
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.650
2w3v TOPDihydrofolate reductase / 0.650
3frf XCFDihydrofolate reductase 1.5.1.3 0.650
3td8 D2RDihydrofolate reductase 1.5.1.3 0.650