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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3d7z GK5 Mitogen-activated protein kinase 14

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3d7z GK5Mitogen-activated protein kinase 14 / 1.193
3iph G11Mitogen-activated protein kinase 14 / 1.023
3gfe P37Mitogen-activated protein kinase 14 / 0.901
3itz P66Mitogen-activated protein kinase 14 / 0.835
3e92 G6AMitogen-activated protein kinase 14 / 0.834
4kin 1M8Mitogen-activated protein kinase 14 / 0.823
3s4q NK0Mitogen-activated protein kinase 14 / 0.792
3rin I2OMitogen-activated protein kinase 14 / 0.784
4kiq 1RAMitogen-activated protein kinase 14 / 0.776
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.733
3u8w 09JMitogen-activated protein kinase 14 / 0.726
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.725
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.723
2zb1 GK4Mitogen-activated protein kinase 14 / 0.720
3dt1 P40Mitogen-activated protein kinase 14 / 0.716
3nnu EDBMitogen-activated protein kinase 14 / 0.699
4kip 1R9Mitogen-activated protein kinase 14 / 0.687
3bx5 304Mitogen-activated protein kinase 14 / 0.686
3fkl FKLMitogen-activated protein kinase 14 / 0.686
3e93 19BMitogen-activated protein kinase 14 / 0.683
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.675
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.672
2zb0 GK3Mitogen-activated protein kinase 14 / 0.670
3l8x N4DMitogen-activated protein kinase 14 / 0.662
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.659
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.657