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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cse N22 Uncharacterized protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cse N22Uncharacterized protein / 1.128
3qlz QLZUncharacterized protein / 0.860
3k45 51PDihydrofolate reductase 1.5.1.3 0.774
4kak 06UDihydrofolate reductase 1.5.1.3 0.751
3qlx QLRUncharacterized protein / 0.744
3eem 53VUncharacterized protein / 0.727
3eek 53SUncharacterized protein / 0.711
3eel 53TUncharacterized protein / 0.710
2bl9 CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.697
4h97 53SDihydrofolate reductase 1.5.1.3 0.690
4kd7 9DRDihydrofolate reductase 1.5.1.3 0.672
3d80 Q22Dihydrofolate reductase 1.5.1.3 0.666
4h96 14QDihydrofolate reductase 1.5.1.3 0.665
4ixg IXGDihydrofolate reductase 1.5.1.3 0.665
2bla CP6Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.659
1hfp MOTDihydrofolate reductase 1.5.1.3 0.658
3nxo D2BDihydrofolate reductase 1.5.1.3 0.653
4p68 MTXDihydrofolate reductase / 0.651