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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cs9 NIL Tyrosine-protein kinase ABL1 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 1.304
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.900
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.892
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.869
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.868
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 0.849
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.829
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.814
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.808
3gfe P37Mitogen-activated protein kinase 14 / 0.796
2hiw 7MPTyrosine-protein kinase ABL1 2.7.10.2 0.793
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.777
4r7i STIMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.772
3dtw A96Vascular endothelial growth factor receptor 2 2.7.10.1 0.771
4bkj STIEpithelial discoidin domain-containing receptor 1 2.7.10.1 0.768
4kin 1M8Mitogen-activated protein kinase 14 / 0.765
4kiq 1RAMitogen-activated protein kinase 14 / 0.764
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 0.762
3bx5 304Mitogen-activated protein kinase 14 / 0.762
4kip 1R9Mitogen-activated protein kinase 14 / 0.760
2rg6 287Mitogen-activated protein kinase 14 / 0.754
2oiq STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.751
3e92 G6AMitogen-activated protein kinase 14 / 0.751
2hz0 GINTyrosine-protein kinase ABL1 2.7.10.2 0.748
3mvm 39PMitogen-activated protein kinase 14 / 0.746
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.736
3itz P66Mitogen-activated protein kinase 14 / 0.735
2p4i MR9Angiopoietin-1 receptor 2.7.10.1 0.732
3fkl FKLMitogen-activated protein kinase 14 / 0.728
3iph G11Mitogen-activated protein kinase 14 / 0.728
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.725
3s4q NK0Mitogen-activated protein kinase 14 / 0.722
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.715
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.713
3bv3 P39Mitogen-activated protein kinase 14 / 0.704
3l8x N4DMitogen-activated protein kinase 14 / 0.696
2oh4 GIGVascular endothelial growth factor receptor 2 2.7.10.1 0.694
3ocg OCGMitogen-activated protein kinase 14 / 0.692
3kq7 KQ7Mitogen-activated protein kinase 14 / 0.690
3rin I2OMitogen-activated protein kinase 14 / 0.688
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.684
2osc MUHAngiopoietin-1 receptor 2.7.10.1 0.682
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.680
3dt1 P40Mitogen-activated protein kinase 14 / 0.677
1ywn LIFVascular endothelial growth factor receptor 2 2.7.10.1 0.673
3mvl 38PMitogen-activated protein kinase 14 / 0.673
3efl 706Vascular endothelial growth factor receptor 2 2.7.10.1 0.668
2hzn KINTyrosine-protein kinase ABL1 2.7.10.2 0.663
4qrc 0LIFibroblast growth factor receptor 4 2.7.10.1 0.662
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.661
3lfa 1N1Mitogen-activated protein kinase 14 / 0.660
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.658
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.655
3orn 3ORDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.653
3qri 919Tyrosine-protein kinase ABL1 2.7.10.2 0.653
5hid B1ESerine/threonine-protein kinase B-raf 2.7.11.1 0.652
4aa0 AA0Mitogen-activated protein kinase 14 / 0.651
3ugc 046Tyrosine-protein kinase JAK2 / 0.650