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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cly ACP Fibroblast growth factor receptor 2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cly ACPFibroblast growth factor receptor 2 / 1.102
2pz5 ACPFibroblast growth factor receptor 2 / 0.915
2pzp ACPFibroblast growth factor receptor 2 / 0.905
2py3 ACPFibroblast growth factor receptor 2 / 0.890
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.810
1mq4 ADPAurora kinase A 2.7.11.1 0.806
4ceg ADPAurora kinase A 2.7.11.1 0.800
2pyw ADPMethylthioribose kinase 2.7.1.100 0.791
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.786
3bu5 ATPInsulin receptor 2.7.10.1 0.781
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.778
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.776
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.775
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.774
4utd ACPAurora kinase A 2.7.11.1 0.773
4xlv ACPInsulin receptor 2.7.10.1 0.771
3c50 ADPRhodopsin kinase / 0.770
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.766
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.761
4dee ADPAurora kinase A 2.7.11.1 0.759
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.757
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.756
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.756
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.751
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.751
4o4d ATPKinase / 0.750
2dwb ANPAurora kinase A 2.7.11.1 0.749
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.747
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
5byl GCPBifunctional AAC/APH 2.3.1 0.745
1m0w ANPGlutathione synthetase 6.3.2.3 0.744
5dr2 ATPAurora kinase A 2.7.11.1 0.744
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.742
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.742
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.741
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.740
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.738
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.737
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.736
3nie ANPMitogen-activated protein kinase / 0.735
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.735
5dt3 ATPAurora kinase A 2.7.11.1 0.735
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.732
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.730
5drd ATPAurora kinase A 2.7.11.1 0.730
3c4z ADPRhodopsin kinase / 0.729
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.729
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.726
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.725
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.725
1ol5 ADPAurora kinase A 2.7.11.1 0.725
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.722
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.722
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.721
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.721
5iqb GNPBifunctional AAC/APH 2.3.1 0.720
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.718
5dn3 ATPAurora kinase A 2.7.11.1 0.718
2pun ACPMethylthioribose kinase 2.7.1.100 0.717
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.716
3orm AGSSerine/threonine protein kinase / 0.715
2pul ACPMethylthioribose kinase 2.7.1.100 0.714
5dnr ATPAurora kinase A 2.7.11.1 0.714
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.712
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.712
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.712
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.711
4c3r ACPAurora kinase A 2.7.11.1 0.711
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.710
3c4w ATPRhodopsin kinase / 0.710
3tw6 ADPPyruvate carboxylase / 0.710
4gyi ADPUncharacterized protein / 0.710
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.708
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.708
2pup ADPMethylthioribose kinase 2.7.1.100 0.708
3t8o ATPRhodopsin kinase / 0.708
5iqh GNPBifunctional AAC/APH 2.3.1 0.708
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.707
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.705
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.705
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.701
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.701
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.700
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.700
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.700
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.700
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.699
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.698
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.696
3qc9 ADPRhodopsin kinase / 0.696
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
5ce3 ADPProtein kinase YopO / 0.696
5eg3 ACPFibroblast growth factor receptor 2 / 0.696
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.694
1u54 ACPActivated CDC42 kinase 1 / 0.694
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.694
3rv4 ADPBiotin carboxylase 6.3.4.14 0.694
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.693
4ix5 ANPUncharacterized protein / 0.693
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.692
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.692
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.691
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.691
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.690
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.688
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.688
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.688
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.688
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.687
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.686
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.686
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.684
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.684
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.683
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.682
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.681
1ol7 ADPAurora kinase A 2.7.11.1 0.681
4ysj ADPCalmodulin-like domain protein kinase / 0.681
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.680
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
5dt4 ATPAurora kinase A 2.7.11.1 0.679
1ol6 ATPAurora kinase A 2.7.11.1 0.678
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.677
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.676
3c4x ATPRhodopsin kinase / 0.675
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.675
3b2t M33Fibroblast growth factor receptor 2 / 0.674
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.674
2vqd AP2Biotin carboxylase 6.3.4.14 0.673
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.673
3oro AGSSerine/threonine protein kinase / 0.672
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.672
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.671
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.671
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.670
5dos ATPAurora kinase A 2.7.11.1 0.670
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.669
4o4e ATPKinase / 0.669
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.668
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.668
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.668
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.668
4o4f ATPKinase / 0.668
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.667
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
4ffm ADPUncharacterized protein / 0.667
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5iqa GNPBifunctional AAC/APH 2.3.1 0.666
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.664
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.664
2pml ANPUncharacterized protein / 0.664
4n57 ADPAPH(2'')-Id / 0.664
5l8j ADPAurora kinase A 2.7.11.1 0.664
2pui ADPMethylthioribose kinase 2.7.1.100 0.663
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.663
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.663
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.662
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.662
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.661
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.661
4q5h ANPProtein kinase OspG 2.7 0.661
3tdw GDPGentamicin resistance protein / 0.660
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.660
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.660
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.657
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
4o0w ADNAurora kinase A 2.7.11.1 0.657
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.656
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4zgn ATPCell division cycle protein 123 / 0.655
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.654
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.653
3llt ANPProtein serine/threonine kinase-1 / 0.653
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
1jdb ADPCarbamoyl-phosphate synthase large chain / 0.652
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.652
4j98 ACPFibroblast growth factor receptor 2 / 0.652
4o0u ADNAurora kinase A 2.7.11.1 0.652
5iqf GDPBifunctional AAC/APH 2.3.1 0.652
2pwl ACPFibroblast growth factor receptor 2 / 0.651
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.651
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.651
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.651
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.650
4ee3 UDHBeta-1,4-galactosyltransferase 1 / 0.650
4o1p ANPRibonuclease L / 0.650