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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3cd2 MTX Dihydrofolate reductase 1.5.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3cd2 MTXDihydrofolate reductase 1.5.1.3 1.046
1u70 MTXDihydrofolate reductase 1.5.1.3 0.888
1dls MTXDihydrofolate reductase 1.5.1.3 0.879
1rg7 MTXDihydrofolate reductase 1.5.1.3 0.868
4p66 MTXDihydrofolate reductase / 0.863
3drc MTXDihydrofolate reductase 1.5.1.3 0.859
1ra3 MTXDihydrofolate reductase 1.5.1.3 0.858
3dfr MTXDihydrofolate reductase 1.5.1.3 0.858
2drc MTXDihydrofolate reductase 1.5.1.3 0.845
1dra MTXDihydrofolate reductase 1.5.1.3 0.844
3och 2MXDihydrofolate reductase 1.5.1.3 0.840
3eig MTXDihydrofolate reductase 1.5.1.3 0.838
3ia4 MTXDihydrofolate reductase / 0.838
1dhi MTXDihydrofolate reductase 1.5.1.3 0.834
2qk8 MTXDihydrofolate reductase / 0.833
1u72 MTXDihydrofolate reductase 1.5.1.3 0.831
4qi9 MTXDihydrofolate reductase / 0.831
4dfr MTXDihydrofolate reductase 1.5.1.3 0.825
5hi6 MTXDihydrofolate reductase / 0.825
1df7 MTXDihydrofolate reductase 1.5.1.3 0.820
3dau MTXDihydrofolate reductase 1.5.1.3 0.817
3tq9 MTXDihydrofolate reductase / 0.816
1rh3 MTXDihydrofolate reductase 1.5.1.3 0.815
3ix9 MTXDihydrofolate reductase 1.5.1.3 0.807
1rx3 MTXDihydrofolate reductase 1.5.1.3 0.805
1rb3 MTXDihydrofolate reductase 1.5.1.3 0.801
1e26 GPBDihydrofolate reductase 1.5.1.3 0.796
1dre MTXDihydrofolate reductase 1.5.1.3 0.795
3td8 D2RDihydrofolate reductase 1.5.1.3 0.788
1drb MTXDihydrofolate reductase 1.5.1.3 0.784
2zza FOLDihydrofolate reductase / 0.784
4x5f FOLDihydrofolate reductase 1.5.1.3 0.779
1tdr MTXDihydrofolate reductase 1.5.1.3 0.778
2cd2 FOLDihydrofolate reductase 1.5.1.3 0.772
1dhf FOLDihydrofolate reductase 1.5.1.3 0.771
4m6k FOLDihydrofolate reductase 1.5.1.3 0.771
1ohj COPDihydrofolate reductase 1.5.1.3 0.766
4nx7 FOLDihydrofolate reductase 1.5.1.3 0.766
4p68 MTXDihydrofolate reductase / 0.763
1ohk COPDihydrofolate reductase 1.5.1.3 0.762
1rx7 FOLDihydrofolate reductase 1.5.1.3 0.762
3ql3 FOLDihydrofolate reductase 1.5.1.3 0.762
1dyh DZFDihydrofolate reductase 1.5.1.3 0.759
1hfr MOTDihydrofolate reductase 1.5.1.3 0.759
3tqb FOLDihydrofolate reductase / 0.759
4i13 FOLDihydrofolate reductase 1.5.1.3 0.756
4kfj FOLDihydrofolate reductase 1.5.1.3 0.755
4cd2 FOLDihydrofolate reductase 1.5.1.3 0.754
1jom FFODihydrofolate reductase 1.5.1.3 0.752
4i1n FOLDihydrofolate reductase 1.5.1.3 0.750
4x5g FOLDihydrofolate reductase 1.5.1.3 0.749
1hfq MOTDihydrofolate reductase 1.5.1.3 0.747
1dhj MTXDihydrofolate reductase 1.5.1.3 0.746
2d0k FOLDihydrofolate reductase 1.5.1.3 0.746
7dfr FOLDihydrofolate reductase 1.5.1.3 0.745
4x5i FOLDihydrofolate reductase 1.5.1.3 0.744
5ccc DDFDihydrofolate reductase 1.5.1.3 0.743
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.742
4x5h FOLDihydrofolate reductase 1.5.1.3 0.741
1ra2 FOLDihydrofolate reductase 1.5.1.3 0.739
1rx5 DDFDihydrofolate reductase 1.5.1.3 0.739
4nx6 FOLDihydrofolate reductase 1.5.1.3 0.736
1rx4 DDFDihydrofolate reductase 1.5.1.3 0.734
1hfp MOTDihydrofolate reductase 1.5.1.3 0.733
1drf FOLDihydrofolate reductase 1.5.1.3 0.732
3frd DHFDihydrofolate reductase 1.5.1.3 0.732
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.730
4kjj FOLDihydrofolate reductase 1.5.1.3 0.730
4ej1 FOLDihydrofolate reductase 1.5.1.3 0.729
4keb FOLDihydrofolate reductase 1.5.1.3 0.729
2w3m FOLDihydrofolate reductase 1.5.1.3 0.727
3gi2 GHWDihydrofolate reductase 1.5.1.3 0.727
3nu0 3TUDihydrofolate reductase 1.5.1.3 0.725
1dyi FOLDihydrofolate reductase 1.5.1.3 0.722
1rx2 FOLDihydrofolate reductase 1.5.1.3 0.718
1cd2 FOLDihydrofolate reductase 1.5.1.3 0.715
3ghw GHWDihydrofolate reductase 1.5.1.3 0.710
1dyj DDFDihydrofolate reductase 1.5.1.3 0.709
3dat MTXDihydrofolate reductase / 0.708
4fhb FOLDihydrofolate reductase 1.5.1.3 0.706
4m6l 21VDihydrofolate reductase 1.5.1.3 0.700
4dpd DHFBifunctional dihydrofolate reductase-thymidylate synthase / 0.696
1jol FFODihydrofolate reductase 1.5.1.3 0.694
1ra8 FOLDihydrofolate reductase 1.5.1.3 0.692
1rx6 DDFDihydrofolate reductase 1.5.1.3 0.692
2fzi DH3Dihydrofolate reductase 1.5.1.3 0.692
3ntz 3TZDihydrofolate reductase 1.5.1.3 0.692
2dhf DZFDihydrofolate reductase 1.5.1.3 0.687
1qzf FOLBifunctional dihydrofolate reductase-thymidylate synthase / 0.686
1re7 FOLDihydrofolate reductase 1.5.1.3 0.686
2fzj DH3Dihydrofolate reductase 1.5.1.3 0.686
1dds MTXDihydrofolate reductase 1.5.1.3 0.685
2fzh DH1Dihydrofolate reductase 1.5.1.3 0.685
1rx8 FOLDihydrofolate reductase 1.5.1.3 0.678
4ixg IXGDihydrofolate reductase 1.5.1.3 0.673
1rd7 FOLDihydrofolate reductase 1.5.1.3 0.671
5cc9 DDFDihydrofolate reductase 1.5.1.3 0.671
1daj MOTDihydrofolate reductase 1.5.1.3 0.668
3fyw XCFDihydrofolate reductase 1.5.1.3 0.668
1bk0 ACVIsopenicillin N synthase 1.21.3.1 0.665
2w9h TOPDihydrofolate reductase 1.5.1.3 0.665
1hb1 OCVIsopenicillin N synthase 1.21.3.1 0.663
1aoe GW3Dihydrofolate reductase 1.5.1.3 0.662
1drt PCVClavaminate synthase 1 1.14.11.21 0.659
1u5a BIKL-lactate dehydrogenase 1.1.1.27 0.659
1oc1 ASVIsopenicillin N synthase 1.21.3.1 0.654
1u5c BIKL-lactate dehydrogenase 1.1.1.27 0.654
4ie5 MD6Alpha-ketoglutarate-dependent dioxygenase FTO / 0.654
1ddr MTXDihydrofolate reductase 1.5.1.3 0.652
3uwq U5POrotidine 5'-phosphate decarboxylase / 0.652
3fvu IACKynurenine--oxoglutarate transaminase 1 2.6.1.7 0.651