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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bur TES 3-oxo-5-beta-steroid 4-dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3bur TES3-oxo-5-beta-steroid 4-dehydrogenase / 1.206
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.890
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.736
1lhw ESMSex hormone-binding globulin / 0.710
1fdu ESTEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.694
5dxg ESTEstrogen receptor / 0.694
1qyx ASDEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.691
4jbt ASDCytochrome P450 monooxygenase / 0.690
3ov4 EQUSteroid Delta-isomerase 5.3.3.1 0.689
3l03 4OHEstrogen receptor / 0.679
4y8w STRSteroid 21-hydroxylase / 0.677
4xo7 ASDAldo-keto reductase family 1 member C2 / 0.665
3uud ESTEstrogen receptor / 0.661
2oax SNLMineralocorticoid receptor / 0.660
1zhz ERGOxysterol-binding protein homolog 4 / 0.659
4qe6 JN3Bile acid receptor / 0.659
3oll ESTEstrogen receptor beta / 0.658
2ao6 R18Androgen receptor / 0.656
2w8y NDRProgesterone receptor / 0.652
3myt EQUSteroid Delta-isomerase 5.3.3.1 0.651