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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bu5 ATP Insulin receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3bu5 ATPInsulin receptor 2.7.10.1 1.014
4xlv ACPInsulin receptor 2.7.10.1 0.918
2pui ADPMethylthioribose kinase 2.7.1.100 0.805
4gyi ADPUncharacterized protein / 0.800
3cly ACPFibroblast growth factor receptor 2 / 0.781
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.770
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.769
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.768
2pyw ADPMethylthioribose kinase 2.7.1.100 0.768
4dee ADPAurora kinase A 2.7.11.1 0.764
5dr2 ATPAurora kinase A 2.7.11.1 0.764
5dn3 ATPAurora kinase A 2.7.11.1 0.761
5dt3 ATPAurora kinase A 2.7.11.1 0.761
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.760
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.760
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.758
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.757
3c4z ADPRhodopsin kinase / 0.754
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.754
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.751
5dos ATPAurora kinase A 2.7.11.1 0.751
4utd ACPAurora kinase A 2.7.11.1 0.750
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.747
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.746
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.745
2olc ADPMethylthioribose kinase 2.7.1.100 0.743
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.741
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.739
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.738
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.737
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.736
2pul ACPMethylthioribose kinase 2.7.1.100 0.733
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.732
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.731
2py3 ACPFibroblast growth factor receptor 2 / 0.729
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.728
2pun ACPMethylthioribose kinase 2.7.1.100 0.725
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.723
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.721
1mq4 ADPAurora kinase A 2.7.11.1 0.721
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.721
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.720
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.719
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.717
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.717
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.717
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.717
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.716
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.714
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.714
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.713
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.713
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.712
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.712
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.712
3c50 ADPRhodopsin kinase / 0.710
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.710
5dt4 ATPAurora kinase A 2.7.11.1 0.710
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.708
2pup ADPMethylthioribose kinase 2.7.1.100 0.707
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.706
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.705
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.705
5iqe GNPBifunctional AAC/APH 2.3.1 0.705
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.704
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.704
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.704
4bn1 ADPAurora kinase A 2.7.11.1 0.703
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.703
4ffr ATPUncharacterized protein / 0.703
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.703
5iqi GNPBifunctional AAC/APH 2.3.1 0.703
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.702
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.701
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.701
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.701
5ce3 ADPProtein kinase YopO / 0.701
5drd ATPAurora kinase A 2.7.11.1 0.701
5eg3 ACPFibroblast growth factor receptor 2 / 0.700
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.699
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.698
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.697
4qny ANPMitogen activated protein kinase, putative / 0.697
1ol5 ADPAurora kinase A 2.7.11.1 0.696
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.696
2pz5 ACPFibroblast growth factor receptor 2 / 0.695
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.695
3qc9 ADPRhodopsin kinase / 0.695
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.694
2pzp ACPFibroblast growth factor receptor 2 / 0.694
4ceg ADPAurora kinase A 2.7.11.1 0.694
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.694
4o4d ATPKinase / 0.693
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.693
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.692
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.692
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.692
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.691
5iqh GNPBifunctional AAC/APH 2.3.1 0.691
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.690
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.690
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.690
4o4f ATPKinase / 0.689
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.688
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.688
4o4e ATPKinase / 0.688
5dnr ATPAurora kinase A 2.7.11.1 0.688
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.686
4c3p ACPAurora kinase A 2.7.11.1 0.686
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.685
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.684
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.683
1t36 ADPCarbamoyl-phosphate synthase large chain / 0.683
2j9g ADPBiotin carboxylase 6.3.4.14 0.683
3c4w ATPRhodopsin kinase / 0.683
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.683
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.683
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.683
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
2dwb ANPAurora kinase A 2.7.11.1 0.682
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.682
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.682
4ix5 ANPUncharacterized protein / 0.682
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.682
5iqd GNPBifunctional AAC/APH 2.3.1 0.682
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.681
5iqa GNPBifunctional AAC/APH 2.3.1 0.681
5iqb GNPBifunctional AAC/APH 2.3.1 0.681
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.679
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.679
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.679
4ysj ADPCalmodulin-like domain protein kinase / 0.677
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.677
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.675
3wo1 ADPAlanine--anticapsin ligase / 0.675
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.675
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.674
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.672
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.672
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.672
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.672
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.672
5cnn ANPEpidermal growth factor receptor 2.7.10.1 0.672
2vqd AP2Biotin carboxylase 6.3.4.14 0.671
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.671
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4ork GDPBifunctional AAC/APH 2.3.1 0.671
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.670
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.669
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.669
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.669
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.668
3wo0 ADPAlanine--anticapsin ligase / 0.667
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.667
4ffl ADPUncharacterized protein / 0.666
3nie ANPMitogen-activated protein kinase / 0.665
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.665
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.663
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.663
3t8o ATPRhodopsin kinase / 0.663
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.662
3c4x ATPRhodopsin kinase / 0.662
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.662
4n57 ADPAPH(2'')-Id / 0.662
5l8l ADPAurora kinase A 2.7.11.1 0.662
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.661
3ort AGSSerine/threonine protein kinase / 0.661
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.661
1ir3 ANPInsulin receptor 2.7.10.1 0.660
3tdw GDPGentamicin resistance protein / 0.660
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.660
5l8j ADPAurora kinase A 2.7.11.1 0.660
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.659
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.659
3orl AGSSerine/threonine protein kinase / 0.659
3pff ADPATP-citrate synthase 2.3.3.8 0.659
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
5byl GCPBifunctional AAC/APH 2.3.1 0.659
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.658
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.658
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.658
4q5h ANPProtein kinase OspG 2.7 0.658
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.658
4jrn ANPRhoptry kinase family protein / 0.657
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.656
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.656
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.656
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.654
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.654
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.654
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.654
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.654
5l8k ADPAurora kinase A 2.7.11.1 0.654
2qo9 ANPEphrin type-A receptor 3 2.7.10.1 0.653
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.652
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.652
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.652
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.652
3oro AGSSerine/threonine protein kinase / 0.651
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650