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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bkb STU Tyrosine-protein kinase Fes/Fps 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3bkb STUTyrosine-protein kinase Fes/Fps 2.7.10.2 1.071
3cbl STUTyrosine-protein kinase Fes/Fps 2.7.10.2 1.064
3cd3 STUTyrosine-protein kinase Fes/Fps 2.7.10.2 0.986
2dq7 STUTyrosine-protein kinase Fyn 2.7.10.2 0.902
1u59 STUTyrosine-protein kinase ZAP-70 2.7.10.2 0.889
2j0j 4STFocal adhesion kinase 1 2.7.10.2 0.882
2j0m 4STFocal adhesion kinase 1 2.7.10.2 0.855
2yn8 STUEphrin type-B receptor 4 2.7.10.1 0.846
2gcd STUSerine/threonine-protein kinase TAO2 2.7.11.1 0.837
1aq1 STUCyclin-dependent kinase 2 2.7.11.22 0.822
1nvr STUSerine/threonine-protein kinase Chk1 2.7.11.1 0.795
1nvq UCNSerine/threonine-protein kinase Chk1 2.7.11.1 0.779
2nry STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.776
1nxk STUMAP kinase-activated protein kinase 2 2.7.11.1 0.773
1oky STU3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.765
4bf2 STUMitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.762
1yvj 4STTyrosine-protein kinase JAK3 2.7.10.2 0.758
1sm2 STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.754
4u9a STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.754
4c34 STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.752
4wsq KSAAP2-associated protein kinase 1 2.7.11.1 0.748
1okz UCN3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.742
4u97 STUInterleukin-1 receptor-associated kinase 4 2.7.11.1 0.742
1x8b 824Wee1-like protein kinase 2.7.10.2 0.740
1snu STUTyrosine-protein kinase ITK/TSK 2.7.10.2 0.735
4fr4 STUSerine/threonine-protein kinase 32A 2.7.11.1 0.735
1stc STUcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
2io6 330Wee1-like protein kinase 2.7.10.2 0.733
1q3d STUGlycogen synthase kinase-3 beta 2.7.11.26 0.730
3zew STUEphrin type-B receptor 4 2.7.10.1 0.728
1pkd UCNCyclin-dependent kinase 2 2.7.11.22 0.725
2j0k 4STFocal adhesion kinase 1 2.7.10.2 0.719
4qmy STUSerine/threonine-protein kinase 24 2.7.11.1 0.718
5e8x STUTGF-beta receptor type-1 2.7.11.30 0.715
3bi6 396Wee1-like protein kinase 2.7.10.2 0.704
3f69 XDRSerine/threonine-protein kinase PknB 2.7.11.1 0.697
4erw STUCyclin-dependent kinase 2 2.7.11.22 0.683
4yzc STUSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.675
3cqe P91Wee1-like protein kinase 2.7.10.2 0.671
3cr0 809Wee1-like protein kinase 2.7.10.2 0.668
4e5f 0N7Polymerase acidic protein / 0.660
4kik KSAInhibitor of nuclear factor kappa-B kinase subunit beta 2.7.11.10 0.658
4cd0 AWJALK tyrosine kinase receptor 2.7.10.1 0.656
4ccu AWFALK tyrosine kinase receptor 2.7.10.1 0.651
2xmy CDKCyclin-dependent kinase 2 2.7.11.22 0.650