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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bht MFR Cyclin-dependent kinase 2 2.7.11.22

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3bht MFRCyclin-dependent kinase 2 2.7.11.22 0.873
4bid IE8Mitogen-activated protein kinase kinase kinase 5 2.7.11.25 0.724
3zls 92PDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.711
4e6d 0NUTyrosine-protein kinase JAK2 / 0.681
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.670
4i5c C5ITyrosine-protein kinase JAK1 / 0.665
2pzr ACPFibroblast growth factor receptor 2 / 0.658
1jpa ANPEphrin type-B receptor 2 2.7.10.1 0.657
2zoq 5IDMitogen-activated protein kinase 3 2.7.11.24 0.656
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.655
3t8o ATPRhodopsin kinase / 0.654
4k8a K8AFocal adhesion kinase 1 2.7.10.2 0.650