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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bgq VX2 Serine/threonine-protein kinase pim-1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3bgq VX2Serine/threonine-protein kinase pim-1 2.7.11.1 1.025
4a7c E46Serine/threonine-protein kinase pim-1 2.7.11.1 0.741
2obj VRVSerine/threonine-protein kinase pim-1 2.7.11.1 0.740
3ti1 B49Cyclin-dependent kinase 2 2.7.11.22 0.670
4fkv 61KCyclin-dependent kinase 2 2.7.11.22 0.664
1m2r MNYCasein kinase II subunit alpha 2.7.11.1 0.663
2vag V25Dual specificity protein kinase CLK1 2.7.12.1 0.663
2vti LZ3Cyclin-dependent kinase 2 2.7.11.22 0.663
2uzt SS3cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
2xbj XBJSerine/threonine-protein kinase Chk2 2.7.11.1 0.662
3l9m L9McAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
4enx Z20Serine/threonine-protein kinase pim-1 2.7.11.1 0.659
3ma3 01ISerine/threonine-protein kinase pim-1 2.7.11.1 0.658
4fob 0USALK tyrosine kinase receptor 2.7.10.1 0.658
4fkp LS5Cyclin-dependent kinase 2 2.7.11.22 0.657
1jcm 137Tryptophan biosynthesis protein TrpCF 4.1.1.48 0.656
3r02 UNMSerine/threonine-protein kinase pim-1 2.7.11.1 0.656
1pmv 537Mitogen-activated protein kinase 10 2.7.11.24 0.655
3blr CPBCyclin-dependent kinase 9 2.7.11.22 0.653
3jxw LXGSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
4fsn A58Serine/threonine-protein kinase Chk1 2.7.11.1 0.653