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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bgi SAH Thiopurine S-methyltransferase 2.1.1.67

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 1.052
2bzg SAHThiopurine S-methyltransferase 2.1.1.67 0.959
3v97 SAHRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.804
1yf3 SAHDNA adenine methylase / 0.774
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.772
3grr SAHProbable ribosomal RNA small subunit methyltransferase A / 0.771
4gbe SAHDNA adenine methylase 2.1.1.72 0.754
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.754
2qe6 SAMUncharacterized protein / 0.753
2g1p SAHDNA adenine methylase 2.1.1.72 0.751
2gs9 SAHUncharacterized protein / 0.747
2ore SAHDNA adenine methylase 2.1.1.72 0.746
4azw SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.746
3mte SAM16S rRNA (adenine(1408)-N(1))-methyltransferase 2.1.1.180 0.745
1y9d FADPyruvate oxidase 1.2.3.3 0.741
4rtk SAHDNA adenine methylase 2.1.1.72 0.741
5dxa SFGHistone-arginine methyltransferase CARM1 / 0.741
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.738
4nec SAHPutative SAM-dependent methyltransferase / 0.738
5je2 SAHMethyl transferase / 0.735
3egv SAHRibosomal protein L11 methyltransferase 2.1.1 0.732
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.732
2o07 MTASpermidine synthase 2.5.1.16 0.728
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.728
3lcc SAHThiocyanate methyltransferase 1 / 0.728
4rts SAMDNA adenine methylase 2.1.1.72 0.727
2dpm SAMModification methylase DpnIIA 2.1.1.72 0.726
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.726
3cjt SAHRibosomal protein L11 methyltransferase 2.1.1 0.726
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.726
4fzv SAM5-methylcytosine rRNA methyltransferase NSUN4 2.1.1 0.726
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.726
1yqz FADCoenzyme A disulfide reductase / 0.725
2yx1 SFGtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.725
1g60 SAMModification methylase MboII 2.1.1.72 0.724
1p1c SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.723
1boo SAHModification methylase PvuII 2.1.1.113 0.722
4uy6 SAHHistidine N-alpha-methyltransferase / 0.722
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.722
1eg2 MTAModification methylase RsrI 2.1.1.72 0.720
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.720
3duw SAHO-methyltransferase, putative / 0.720
5dx1 SFGHistone-arginine methyltransferase CARM1 / 0.720
3mht SAHModification methylase HhaI 2.1.1.37 0.717
3fpf MTAUncharacterized protein / 0.716
4gqb 0XUProtein arginine N-methyltransferase 5 / 0.716
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.716
3iv6 SAMUncharacterized protein / 0.715
3rw9 DSHSpermidine synthase 2.5.1.16 0.715
3tm4 SAMUncharacterized protein / 0.715
4lwp SAHArginine N-methyltransferase, putative / 0.715
5i39 FADL-amino acid deaminase / 0.715
5dxj SFGHistone-arginine methyltransferase CARM1 / 0.714
3tsc NADUncharacterized protein / 0.711
3lby SAHUncharacterized protein / 0.710
3b3f SAHHistone-arginine methyltransferase CARM1 / 0.709
2y1x SAHHistone-arginine methyltransferase CARM1 / 0.707
4wec NADShort chain dehydrogenase / 0.707
5dx8 SFGHistone-arginine methyltransferase CARM1 / 0.707
3nmu SAMFibrillarin-like rRNA/tRNA 2'-O-methyltransferase / 0.705
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.703
4rtr SAMDNA adenine methylase 2.1.1.72 0.703
1bc5 SAHChemotaxis protein methyltransferase 2.1.1.80 0.702
3sso SAHMycinamicin VI 2''-O-methyltransferase / 0.702
1wy7 SAHUncharacterized protein / 0.701
4b63 FADL-ornithine N(5)-monooxygenase / 0.701
4yac NAIC alpha-dehydrogenase / 0.700
3g07 SAM7SK snRNA methylphosphate capping enzyme 2.1.1 0.699
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.698
4gol SA8DNA adenine methylase 2.1.1.72 0.698
4rvd SAMD-mycarose 3-C-methyltransferase / 0.698
1p1i NADInositol-3-phosphate synthase 5.5.1.4 0.697
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.697
4blw SAHRibosomal RNA large subunit methyltransferase J / 0.697
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.697
3dmh SAMProbable ribosomal RNA small subunit methyltransferase / 0.696
2hmv ADPKtr system potassium uptake protein A / 0.695
4tlx FDAKtzI / 0.695
4tm1 FDAKtzI / 0.695
4tm4 FDAKtzI / 0.695
4yuz S4MSpermidine synthase, putative / 0.695
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.694
1nw6 SFGModification methylase RsrI 2.1.1.72 0.693
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.693
3a27 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.693
3c3y SAHO-methyltransferase / 0.693
4rto SFGDNA adenine methylase 2.1.1.72 0.693
1ahh NAD7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.692
1txz APRProbable ADP-ribose 1''-phosphate phosphatase YML087W 3.1.3.84 0.692
3fri SAH16S rRNA methylase / 0.692
4gc9 SAMDimethyladenosine transferase 1, mitochondrial 2.1.1 0.692
5jdz SAHMethyl transferase / 0.692
2zzm SAMtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.691
3a4t SFGtRNA (cytosine(48)-C(5))-methyltransferase 2.1.1 0.691
4fwe FADLysine-specific histone demethylase 1B 1 0.691
4mb2 ATPUncharacterized protein / 0.691
1g38 NEAModification methylase TaqI 2.1.1.72 0.690
1skm SAHModification methylase HhaI 2.1.1.37 0.690
1sqf SAMRibosomal RNA small subunit methyltransferase B 2.1.1.176 0.690
4rtj SFGDNA adenine methylase 2.1.1.72 0.690
5je4 SAHMethyl transferase / 0.690
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.688
1d2h SAHGlycine N-methyltransferase 2.1.1.20 0.687
1ges FADGlutathione reductase 1.8.1.7 0.687
2pt6 S4MSpermidine synthase / 0.687
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.687
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.687
2eju SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.686
2z6u SAHModification methylase HhaI 2.1.1.37 0.686
3ou2 SAHSAM-dependent methyltransferase / 0.686
5e72 SAMN2, N2-dimethylguanosine tRNA methyltransferase / 0.686
1f8r FADL-amino-acid oxidase 1.4.3.2 0.685
7mht SAHModification methylase HhaI 2.1.1.37 0.685
3ec7 NADInositol 2-dehydrogenase / 0.684
4rtm SAMDNA adenine methylase 2.1.1.72 0.684
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.684
3vc1 SAHGeranyl diphosphate 2-C-methyltransferase 2.1.1.255 0.683
4dcm SAMRibosomal RNA large subunit methyltransferase G 2.1.1.174 0.683
4xcx SAHSmall RNA 2'-O-methyltransferase / 0.683
5jr3 SAHCarminomycin 4-O-methyltransferase DnrK 2.1.1.292 0.683
4poo SAMPutative RNA methylase / 0.682
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.681
3e8s SAHUncharacterized protein / 0.681
3lcu SAH16S rRNA (guanine(1405)-N(7))-methyltransferase 2.1.1.179 0.681
5bxy SAHPutative RNA methylase family UPF0020 / 0.681
4ckc SAHmRNA-capping enzyme catalytic subunit 2.1.1.56 0.680
4xxg FADCholesterol oxidase 1.1.3.6 0.680
3cbg SAHO-methyltransferase / 0.679
3m6v SAMRibosomal RNA small subunit methyltransferase F / 0.679
3ou6 SAMSAM-dependent methyltransferase / 0.679
3wdm ADN4-phosphopantoate--beta-alanine ligase 6.3.2.36 0.679
4o29 SAHProtein-L-isoaspartate O-methyltransferase / 0.679
4obw SAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial / 0.679
5epe SAHUncharacterized protein / 0.679
1b4v FADCholesterol oxidase 1.1.3.6 0.678
1f3l SAHProtein arginine N-methyltransferase 3 / 0.678
4eqg A5AHistidine triad nucleotide-binding protein 1 3 0.678
2qa2 FADPolyketide oxygenase CabE / 0.677
3ldg SAHUncharacterized protein / 0.677
4eqe KAAHistidine triad nucleotide-binding protein 1 3 0.677
1uay ADNOxidoreductase / 0.676
3uoz FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.676
2ibt NEAModification methylase TaqI 2.1.1.72 0.675
2px5 SAHGenome polyprotein 2.7.7.48 0.675
4kwc SAHMethyltransferase domain family / 0.675
5bp9 SAHPutative methyltransferase protein / 0.675
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.675
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.674
2rgh FADAlpha-Glycerophosphate Oxidase / 0.674
3cn8 FADPolyamine oxidase FMS1 / 0.674
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.673
4icy FADPgaE / 0.673
1r00 SAHAclacinomycin 10-hydroxylase RdmB 4.1.1 0.672
2hnk SAHSAM-dependent O-methyltransferase / 0.672
4fgz SAHPhosphoethanolamine N-methyltransferase / 0.672
1nv8 SAMRelease factor glutamine methyltransferase 2.1.1.297 0.671
2h00 SAHU6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase / 0.671
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.671
4qdk SAHMagnesium-protoporphyrin O-methyltransferase 2.1.1.11 0.671
4x3q SAHSibL / 0.671
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.670
3g8a SAHRibosomal RNA small subunit methyltransferase G / 0.670
2nxe SAMRibosomal protein L11 methyltransferase 2.1.1 0.669
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.669
4kdr SAHUbiquinone biosynthesis O-methyltransferase / 0.669
4ysh FADGlycine oxidase / 0.669
5e8j SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.669
5f8f SFGPossible transcriptional regulatory protein / 0.669
2zcj SAHModification methylase HhaI 2.1.1.37 0.668
2zzn SAMtRNA (guanine(37)-N1)-methyltransferase Trm5b 2.1.1.228 0.668
3cjq SAHRibosomal protein L11 methyltransferase 2.1.1 0.668
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.668
4rv9 SAHD-mycarose 3-C-methyltransferase / 0.668
2iid FADL-amino-acid oxidase 1.4.3.2 0.667
2q3e UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.667
3dzi RGTADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 3.2.2.6 0.667
3iei SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.667
1ger FADGlutathione reductase 1.8.1.7 0.666
3pt6 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.666
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.666
1qaq SFGrRNA adenine N-6-methyltransferase 2.1.1.184 0.665
2v74 SAHHistone-arginine methyltransferase CARM1 / 0.665
3cty FADProbable thioredoxin reductase / 0.665
3ihg FADAklavinone 12-hydroxylase RdmE / 0.665
2gv8 FADThiol-specific monooxygenase 1.14.13 0.664
2ign FADPyranose 2-oxidase / 0.664
2j9l ATPH(+)/Cl(-) exchange transporter 5 / 0.664
3dlc SAMSAM (And some other nucleotide) binding motif:Generic methyltransferase / 0.664
3lfz ADPUncharacterized protein MJ1225 / 0.664
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.664
1nc1 MTH5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 3.2.2.9 0.663
2c7q SAHModification methylase HhaI 2.1.1.37 0.663
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.663
4egu 5GPPutative histidine triad (HIT) protein / 0.663
3pt9 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.662
4u2t FADCholesterol oxidase 1.1.3.6 0.662
5dst SAHProtein arginine N-methyltransferase 8 2.1.1 0.662
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.661
3zwo G2QADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 3.2.2.6 0.660
4c04 SFGProtein arginine N-methyltransferase 6 / 0.660
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.660
10mh SAHModification methylase HhaI 2.1.1.37 0.659
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.659
3sx2 NADUncharacterized protein / 0.659
4u7t SAHDNA (cytosine-5)-methyltransferase 3A 2.1.1.37 0.659
3tos SAHCalS11 / 0.658
5dbj FADFADH2-dependent halogenase PltA / 0.658
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.657
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.657
2z86 UGAChondroitin synthase 2.4.1.175 0.657
3c96 FADFlavin-containing monooxygenase / 0.657
4dmg SAMUncharacterized protein / 0.657
4eak ATP5'-AMP-activated protein kinase subunit gamma-1 / 0.657
1rje SAHLeucine carboxyl methyltransferase 1 2.1.1.233 0.656
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.656
2zwv SAHProbable ribosomal RNA small subunit methyltransferase / 0.656
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.656
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.655
1kr5 SAHProtein-L-isoaspartate(D-aspartate) O-methyltransferase 2.1.1.77 0.655
1orh SAHProtein arginine N-methyltransferase 1 / 0.655
1y8q ATPSUMO-activating enzyme subunit 2 6.3.2 0.655
3atr FDAConserved Archaeal protein / 0.655
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.655
4ft4 SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.655
4r6x SAHPhosphoethanolamine N-methyltransferase / 0.655
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.655
3axs SFGtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.654
3e23 SAMUncharacterized protein / 0.654
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.654
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.654
1mht SAHModification methylase HhaI 2.1.1.37 0.653
3dh0 SAMUncharacterized protein / 0.653
3ldf SAHUncharacterized protein / 0.653
3nwe 662Catechol O-methyltransferase 2.1.1.6 0.653
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.653
4iv0 SAMPhosphoethanolamine N-methyltransferase, putative / 0.653
4y9d NAIC alpha-dehydrogenase / 0.653
2c29 NAPDihydroflavonol 4-reductase / 0.652
2pkm ADNAdenosine kinase 2.7.1.20 0.652
4qi4 FADCellobiose dehydrogenase / 0.652
1rjd SAMLeucine carboxyl methyltransferase 1 2.1.1.233 0.651
2np7 NEAModification methylase TaqI 2.1.1.72 0.651
3bwc SAMSpermidine synthase, putative / 0.651
3fws ANPTranscriptional repressor CcpN / 0.651
3qj4 FADRenalase / 0.651
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.651
3vc2 SAHGeranyl diphosphate 2-C-methyltransferase 2.1.1.255 0.651
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.651
1u28 NADNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.650
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.650
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.650
4mwz SAMPhosphoethanolamine N-methyltransferase, putative / 0.650
4q7f 3D1Uncharacterized protein / 0.650