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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bea IXH Macrophage colony-stimulating factor 1 receptor 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3bea IXHMacrophage colony-stimulating factor 1 receptor 2.7.10.1 0.956
4ji9 1M3Tyrosine-protein kinase JAK2 / 0.728
2xck MH43-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.724
3cjf SAVVascular endothelial growth factor receptor 2 2.7.10.1 0.724
2jkq VG8Focal adhesion kinase 1 2.7.10.2 0.683
2x81 ZZLAurora kinase A 2.7.11.1 0.678
3ztx ZTXAurora kinase B-A 2.7.11.1 0.678
4fsw HK6Serine/threonine-protein kinase Chk1 2.7.11.1 0.675
2x4f 16XMyosin light chain kinase family member 4 2.7.11.1 0.673
4bbe 3O4Tyrosine-protein kinase JAK2 / 0.671
4eut BX7Serine/threonine-protein kinase TBK1 2.7.11.1 0.658
4gmy 0X5Tyrosine-protein kinase JAK2 / 0.656
4b6l 9ZPSerine/threonine-protein kinase PLK3 2.7.11.21 0.651
2vgp AD6Aurora kinase B-A 2.7.11.1 0.650