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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3be2 RAJ Vascular endothelial growth factor receptor 2 2.7.10.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3be2 RAJVascular endothelial growth factor receptor 2 2.7.10.1 1.253
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.849
4tyj 0LIFibroblast growth factor receptor 4 2.7.10.1 0.829
4u0i 0LIMast/stem cell growth factor receptor Kit 2.7.10.1 0.823
4uxq 0LIFibroblast growth factor receptor 4 2.7.10.1 0.817
4v01 0LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b / 0.807
3rgf BAXCyclin-dependent kinase 8 2.7.11.22 0.763
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.762
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.748
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.747
4aa5 NQBMitogen-activated protein kinase 14 / 0.745
4kiq 1RAMitogen-activated protein kinase 14 / 0.741
3d7z GK5Mitogen-activated protein kinase 14 / 0.723
2p4i MR9Angiopoietin-1 receptor 2.7.10.1 0.712
3e92 G6AMitogen-activated protein kinase 14 / 0.699
3dtw A96Vascular endothelial growth factor receptor 2 2.7.10.1 0.690
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.689
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.685
3dt1 P40Mitogen-activated protein kinase 14 / 0.684
3oez STIProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.681
3rin I2OMitogen-activated protein kinase 14 / 0.675
4equ G6ISerine/threonine-protein kinase 10 2.7.11.1 0.675
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.672
4ckr DI1Epithelial discoidin domain-containing receptor 1 2.7.10.1 0.669
3vnt 0JAVascular endothelial growth factor receptor 2 2.7.10.1 0.668
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.668
4at4 T6EBDNF/NT-3 growth factors receptor 2.7.10.1 0.662
1w83 L11Mitogen-activated protein kinase 14 / 0.661
3efl 706Vascular endothelial growth factor receptor 2 2.7.10.1 0.660
4i5h G17Mitogen-activated protein kinase 1 2.7.11.24 0.660
4f6w 0SSCyclin-dependent kinase 8 2.7.11.22 0.656
3mvm 39PMitogen-activated protein kinase 14 / 0.650
4cf8 V7HIntegrase / 0.650
4f7j 0SUCyclin-dependent kinase 8 2.7.11.22 0.650