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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3b4w NAD Aldehyde dehydrogenase family protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3b4w NADAldehyde dehydrogenase family protein / 1.200
4pz2 NADAldehyde dehydrogenase 2-6 / 1.033
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.029
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.018
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 1.013
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.006
4i8p NADAminoaldehyde dehydrogenase 1 / 1.006
3efv NADPutative succinate-semialdehyde dehydrogenase / 1.001
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.999
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.994
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.985
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.976
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.970
4i8q NADPutative betaine aldehyde dehyrogenase / 0.969
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.964
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.950
2jg7 NADAntiquitin / 0.950
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.933
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.932
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.931
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.927
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.919
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.917
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.914
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.904
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.903
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.903
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.902
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.900
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.898
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.894
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.876
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.870
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.863
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.863
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.861
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.857
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.842
3haz NADBifunctional protein PutA / 0.822
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.821
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.809
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.807
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.799
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.786
4pxl NADAldehyde dehydrogenase3 / 0.786
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.759
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.756
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.753
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.751
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.751
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.751
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.750
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.748
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.746
4pt0 NADAldehyde dehydrogenase / 0.742
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.739
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.738
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.737
4i3v NADAldehyde dehydrogenase (NAD+) / 0.736
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.736
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.735
3iwj NADAminoaldehyde dehydrogenase / 0.734
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.731
1bi9 NADRetinal dehydrogenase 2 / 0.728
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.724
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.721
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.720
4c3s NADAldehyde Dehydrogenase / 0.719
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.717
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
4i9b NADPutative betaine aldehyde dehyrogenase / 0.714
4i3w NADAldehyde dehydrogenase (NAD+) / 0.712
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.703
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.701
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.700
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.700
4f3x NADPutative aldehyde dehydrogenase / 0.699
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.695
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.690
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
4nmj NAPAldehyde dehydrogenase / 0.686
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.684
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.683
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.683
4h73 NDPAldehyde dehydrogenase / 0.679
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.677
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.676
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
4nmk NAPAldehyde dehydrogenase / 0.667
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.664
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.660
5dib NADBetaine-aldehyde dehydrogenase / 0.657
3wfj NAD2-dehydropantoate 2-reductase / 0.655
5ez4 NADBetaine-aldehyde dehydrogenase / 0.655
1vbi NADMalate/L-lactate dehydrogenase family protein / 0.652
2voj NADAlanine dehydrogenase 1.4.1.1 0.651