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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3b2w 9NH Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3b2w 9NHTyrosine-protein kinase Lck 2.7.10.2 1.364
2ofv 242Tyrosine-protein kinase Lck 2.7.10.2 0.795
3cs9 NILTyrosine-protein kinase ABL1 2.7.10.2 0.762
3gvu STIAbelson tyrosine-protein kinase 2 2.7.10.2 0.733
3itz P66Mitogen-activated protein kinase 14 / 0.728
2e2b 406Tyrosine-protein kinase ABL1 2.7.10.2 0.717
2og8 1N8Tyrosine-protein kinase Lck 2.7.10.2 0.707
4asd BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.702
1iep STITyrosine-protein kinase ABL1 2.7.10.2 0.699
4aac AAVMitogen-activated protein kinase 14 / 0.696
3wze BAXVascular endothelial growth factor receptor 2 2.7.10.1 0.694
5hi2 BAXSerine/threonine-protein kinase B-raf 2.7.11.1 0.685
3dko IHZEphrin type-A receptor 7 2.7.10.1 0.682
3ugc 046Tyrosine-protein kinase JAK2 / 0.673
3dtw A96Vascular endothelial growth factor receptor 2 2.7.10.1 0.671
2hyy STITyrosine-protein kinase ABL1 2.7.10.2 0.670
3bx5 304Mitogen-activated protein kinase 14 / 0.670
3hng 8STVascular endothelial growth factor receptor 1 2.7.10.1 0.666
4c8b 0LIReceptor-interacting serine/threonine-protein kinase 2 2.7.11.1 0.665
4kiq 1RAMitogen-activated protein kinase 14 / 0.665
3mvm 39PMitogen-activated protein kinase 14 / 0.664
3cem AVDGlycogen phosphorylase, liver form 2.4.1.1 0.658
3e92 G6AMitogen-activated protein kinase 14 / 0.657
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.656
4aa0 AA0Mitogen-activated protein kinase 14 / 0.655