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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3amb VX6 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3amb VX6cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.085
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
3e5a VX6Aurora kinase A 2.7.11.1 0.740
4af3 VX6Aurora kinase B 2.7.11.1 0.720
2f4j VX6Tyrosine-protein kinase ABL1 2.7.10.2 0.692
4bgq 38RCyclin-dependent kinase-like 5 2.7.11.22 0.678
2xa4 AZ5Tyrosine-protein kinase JAK2 / 0.675
4b8m VX6Aurora kinase B-A 2.7.11.1 0.674
3zdu 38RCyclin-dependent kinase-like 3 2.7.11.22 0.672
2xyn VX6Abelson tyrosine-protein kinase 2 2.7.10.2 0.668
3w16 P9JAurora kinase A 2.7.11.1 0.667
1vyz N5BCyclin-dependent kinase 2 2.7.11.22 0.663
4jbq VX6Aurora kinase A 2.7.11.1 0.663
4fkj 11KCyclin-dependent kinase 2 2.7.11.22 0.662
4ek6 10KCyclin-dependent kinase 2 2.7.11.22 0.661
4bdh WVISerine/threonine-protein kinase Chk2 2.7.11.1 0.660
4e5f 0N7Polymerase acidic protein / 0.660
4fki 09KCyclin-dependent kinase 2 2.7.11.22 0.659
2c4g 514Cyclin-dependent kinase 2 2.7.11.22 0.657
2bmc MPYAurora kinase A 2.7.11.1 0.654
3ama SKEcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.650