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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3all FAD 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.316
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.093
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 1.055
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.987
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.978
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.948
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.933
4bjz FADProbable salicylate monooxygenase / 0.923
4bk3 FADProbable salicylate monooxygenase / 0.918
4k5r FADOxygenase / 0.845
4j31 FADKynurenine 3-monooxygenase / 0.832
2qa1 FADPgaE / 0.831
4k2x FADPolyketide oxygenase/hydroxylase / 0.829
4icy FADPgaE / 0.823
3ept FDAPutative FAD-monooxygenase / 0.820
4j2w FADKynurenine 3-monooxygenase / 0.812
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.804
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.797
2eq8 FADDihydrolipoyl dehydrogenase / 0.795
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.793
4bk2 FADProbable salicylate monooxygenase / 0.783
1k0j FADp-hydroxybenzoate hydroxylase / 0.782
3atq FDAConserved Archaeal protein / 0.780
4opi FDAConserved Archaeal protein / 0.780
2qa2 FADPolyketide oxygenase CabE / 0.779
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.778
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.777
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.774
4opu FDAConserved Archaeal protein / 0.774
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.770
1d7l RFLp-hydroxybenzoate hydroxylase / 0.769
3ab1 FADFerredoxin--NADP reductase 1.18.1.2 0.766
3rp8 FADFAD-dependent urate hydroxylase / 0.766
5buk FADFADH2-dependent halogenase / 0.765
1k0l FADp-hydroxybenzoate hydroxylase / 0.764
2eq7 FADDihydrolipoyl dehydrogenase / 0.763
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.763
1geu FADGlutathione reductase 1.8.1.7 0.762
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.761
3c4a FADProtodeoxyviolaceinate monooxygenase 1 0.760
4hb9 FADUncharacterized protein / 0.760
2eq6 FADDihydrolipoyl dehydrogenase / 0.759
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.759
1phh FADp-hydroxybenzoate hydroxylase / 0.758
2tpr FADTrypanothione reductase 1.8.1.12 0.758
3nix FADFlavoprotein/dehydrogenase / 0.757
1gte FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.756
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.756
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.753
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.753
2yqu FADDihydrolipoyl dehydrogenase / 0.751
3lad FADDihydrolipoyl dehydrogenase / 0.750
1zk7 FADMercuric reductase 1.16.1.1 0.749
3atr FDAConserved Archaeal protein / 0.748
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.748
2xdo FADTetX family tetracycline inactivation enzyme / 0.746
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.744
3fmw FADOxygenase / 0.743
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.742
3dk4 FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
3dk9 FADGlutathione reductase, mitochondrial 1.8.1.7 0.741
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.739
1ges FADGlutathione reductase 1.8.1.7 0.739
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.738
1get FADGlutathione reductase 1.8.1.7 0.736
1ger FADGlutathione reductase 1.8.1.7 0.735
3cge FADCoenzyme A disulfide reductase / 0.735
4x4j FADPutative oxygenase / 0.733
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.732
4j36 FADKynurenine 3-monooxygenase / 0.731
4opc FDAConserved Archaeal protein / 0.729
1pdh FASp-hydroxybenzoate hydroxylase / 0.728
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.727
4opt FDAConserved Archaeal protein / 0.727
2eq9 FADDihydrolipoyl dehydrogenase / 0.726
2q7v FADThioredoxin reductase / 0.726
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.726
4j33 FADKynurenine 3-monooxygenase / 0.726
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.725
4ntc FADThioredoxin reductase gliT / 0.725
1cc2 FADCholesterol oxidase 1.1.3.6 0.724
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.724
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.724
2i0z FADNAD(FAD)-utilizing dehydrogenases / 0.724
2r9z FADGlutathione amide reductase / 0.724
1nhq FADNADH peroxidase 1.11.1.1 0.723
1rsg FADPolyamine oxidase FMS1 / 0.722
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.721
4j56 FADThioredoxin reductase 2 1.8.1.9 0.721
4nte FADDepH / 0.721
5dbj FADFADH2-dependent halogenase PltA / 0.721
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.720
2rab FADGlutathione amide reductase / 0.719
4opl FDAConserved Archaeal protein / 0.718
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.717
4gdp FADPolyamine oxidase FMS1 / 0.717
4j34 FADKynurenine 3-monooxygenase / 0.717
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.717
1typ FADTrypanothione reductase 1.8.1.12 0.716
2npx FADNADH peroxidase 1.11.1.1 0.715
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.715
2wow FADTrypanothione reductase / 0.714
2x3n FADProbable FAD-dependent monooxygenase / 0.713
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.712
3nyc FADFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.712
1nhr FADNADH peroxidase 1.11.1.1 0.711
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.711
4gcm FADThioredoxin reductase 1.8.1.9 0.711
1gsn FADGlutathione reductase, mitochondrial 1.8.1.7 0.710
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.710
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.710
1nhp FADNADH peroxidase 1.11.1.1 0.709
3gyj FADCholesterol oxidase 1.1.3.6 0.709
4a99 FADTetX family tetracycline inactivation enzyme / 0.709
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.709
1fea FADTrypanothione reductase 1.8.1.12 0.708
4guv FADTetX family tetracycline inactivation enzyme / 0.708
4u2t FADCholesterol oxidase 1.1.3.6 0.708
2gew FADCholesterol oxidase 1.1.3.6 0.706
3cty FADProbable thioredoxin reductase / 0.706
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.706
4gr1 FADGlutathione reductase, mitochondrial 1.8.1.7 0.706
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.706
1b4v FADCholesterol oxidase 1.1.3.6 0.705
1zx9 FADMercuric reductase 1.16.1.1 0.705
4dsh FDAUncharacterized protein / 0.704
4u2l SFDCholesterol oxidase 1.1.3.6 0.704
2xyo FADTetX family tetracycline inactivation enzyme / 0.703
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.703
2bac FADPutative aminooxidase / 0.702
2hqm FADGlutathione reductase 1.8.1.7 0.702
3k4c FADPyranose 2-oxidase / 0.702
4a6n FADTetX family tetracycline inactivation enzyme / 0.702
4jq9 FADDihydrolipoyl dehydrogenase / 0.701
2zbw FADFerredoxin--NADP reductase / 0.700
3pl8 FADPyranose 2-oxidase / 0.700
4opg FDAConserved Archaeal protein / 0.700
1xpq FADPolyamine oxidase FMS1 / 0.699
2cfy FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.699
2whd FADThioredoxin reductase / 0.698
1lpf FADDihydrolipoyl dehydrogenase 1.8.1.4 0.696
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.696
2wp5 FADTrypanothione reductase / 0.695
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.695
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.694
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.694
2bab FADPutative aminooxidase / 0.693
3p9u FADTetX family tetracycline inactivation enzyme / 0.693
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.691
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.691
4opd FDAConserved Archaeal protein / 0.691
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.690
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.690
4g9k FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.690
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.690
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.689
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.689
4b64 FADL-ornithine N(5)-monooxygenase / 0.689
4em3 FADCoenzyme A disulfide reductase / 0.689
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.689
4nev FADTrypanothione reductase / 0.689
3cgd FADCoenzyme A disulfide reductase / 0.688
5cku FADL-ornithine N(5)-monooxygenase / 0.688
1tyt FADTrypanothione reductase 1.8.1.12 0.687
2gqw FADFerredoxin reductase / 0.687
3cnj FADCholesterol oxidase 1.1.3.6 0.687
4la1 FADThioredoxin glutathione reductase / 0.687
4ocg FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.687
1npx FADNADH peroxidase 1.11.1.1 0.686
3gyi FADCholesterol oxidase 1.1.3.6 0.686
4xwr FADCholesterol oxidase 1.1.3.6 0.686
2z6c FMNPhototropin-1 2.7.11.1 0.685
4dna FADProbable glutathione reductase / 0.685
4u2s FDACholesterol oxidase 1.1.3.6 0.685
1q1w FADPutidaredoxin reductase 1.18.1.5 0.684
1z6l FADPolyamine oxidase FMS1 / 0.684
2gr3 FADFerredoxin reductase / 0.684
4rek FADCholesterol oxidase 1.1.3.6 0.684
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.683
1n4u FAECholesterol oxidase 1.1.3.6 0.683
3dme FADPutative conserved exported protein / 0.683
2wes FADTryptophan 5-halogenase / 0.682
3b6d FAECholesterol oxidase 1.1.3.6 0.682
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.681
2q0k FADThioredoxin reductase 1.8.1.9 0.681
4eeu FMNPhototropin-2 2.7.11.1 0.681
4g6h FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.681
1b8s FADCholesterol oxidase 1.1.3.6 0.680
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.680
1nhs FADNADH peroxidase 1.11.1.1 0.679
1tdo FADL-amino-acid oxidase 1.4.3.2 0.679
4jnq FDAThioredoxin reductase / 0.679
4em4 FADCoenzyme A disulfide reductase / 0.678
1f8w FADNADH peroxidase 1.11.1.1 0.677
3k4n FADPyranose 2-oxidase / 0.677
4cnk FADL-amino acid oxidase / 0.677
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.677
3bg7 FADPyranose 2-oxidase / 0.676
4at0 FADPossible succinate dehydrogenase / 0.676
4b69 FADL-ornithine N(5)-monooxygenase / 0.676
1gth FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.675
2apg FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.675
4gap FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.675
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.674
3lsh FADPyranose 2-oxidase / 0.674
1f8r FADL-amino-acid oxidase 1.4.3.2 0.673
3icr FADCoenzyme A disulfide reductase / 0.673
3ntd FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.673
3ics FADCoenzyme A disulfide reductase / 0.672
1f3p FADFerredoxin reductase / 0.671
2cdu FADNADH oxidase / 0.671
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.671
1n4v FADCholesterol oxidase 1.1.3.6 0.670
1tdf FADThioredoxin reductase 1.8.1.9 0.670
3zdn FADMonoamine oxidase N 1.4.3.4 0.670
4eer FMNPhototropin-2 2.7.11.1 0.670
3q9t FAYUncharacterized protein / 0.669
3we0 FADLysine 2-monooxygenase / 0.669
1cbo FADCholesterol oxidase 1.1.3.6 0.668
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.668
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.668
2jb1 FADL-amino acid oxidase / 0.668
3a27 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.668
3ict FADCoenzyme A disulfide reductase / 0.668
1ijh FADCholesterol oxidase 1.1.3.6 0.667
1n1p FADCholesterol oxidase 1.1.3.6 0.667
1n4w FADCholesterol oxidase 1.1.3.6 0.667
2b9w FADPutative aminooxidase / 0.667
2jb2 FADL-amino acid oxidase / 0.667
3d72 FADVivid PAS protein VVD / 0.667
3qvr FADGlucose oxidase 1.1.3.4 0.667
1onf FADGlutathione reductase 1.8.1.7 0.666
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.666
4ech FADPolyamine oxidase FMS1 / 0.666
3fbs FADOxidoreductase / 0.665
3v76 FDAUncharacterized protein / 0.665
4r38 RBFBlue-light-activated histidine kinase 2 2.7.13.3 0.665
2dji FADPyruvate oxidase / 0.664
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.663
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.662
2pr5 FMNBlue-light photoreceptor / 0.662
1ep3 FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit / 0.661
1i0s FMNFerric-chelate reductase (NAD(P)H) / 0.661
2b9x FADPutative aminooxidase / 0.661
2b9y FADPutative aminooxidase / 0.661
3qvp FADGlucose oxidase 1.1.3.4 0.661
1d7y FADFerredoxin reductase / 0.660
1tde FADThioredoxin reductase 1.8.1.9 0.660
1uum FMNDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.660
2vvl FADMonoamine oxidase N 1.4.3.4 0.660
4cnj FADL-amino acid oxidase / 0.660
2pd7 FADVivid PAS protein VVD / 0.659
4b1b FADThioredoxin reductase 1.8.1.9 0.659
4ylf FADDihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog / 0.659
1n9n FMNPutative blue light receptor / 0.658
2ign FADPyranose 2-oxidase / 0.658
3jqr FADFerredoxin--NADP reductase, apicoplast / 0.658
3a6q FMNFMN-binding protein / 0.657
1q1r FADPutidaredoxin reductase 1.18.1.5 0.656
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.656
4iv8 SAMPhosphoethanolamine N-methyltransferase,putative / 0.656
5ahs FADAcyl-CoA dehydrogenase / 0.656
2np6 NEAModification methylase TaqI 2.1.1.72 0.655
2v3a FADRubredoxin-NAD(+) reductase 1.18.1.1 0.655
2x8g FADThioredoxin glutathione reductase / 0.655
4hc4 SAHProtein arginine N-methyltransferase 6 / 0.655
5cho FADFlavin reductase / 0.655
1i8t FADUDP-galactopyranose mutase 5.4.99.9 0.654
2o06 MTASpermidine synthase 2.5.1.16 0.654
2pdt FADVivid PAS protein VVD / 0.654
2v6o FADThioredoxin glutathione reductase / 0.654
2yg7 FADPutrescine oxidase / 0.654
2z1q FADAcyl-CoA dehydrogenase / 0.654
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.654
1h81 FADPolyamine oxidase 1.5.3.14 0.653
1zmd NAIDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.653
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.653
3lsm SFDPyranose 2-oxidase / 0.653
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.653
4u8n FDAUDP-galactopyranose mutase / 0.653
5ez7 FADProbable FAD-dependent oxidoreductase PA4991 / 0.653
1zy8 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.652
3a6r FMNFMN-binding protein / 0.652
3fg2 FADPutative rubredoxin reductase / 0.652
3is2 FADVivid PAS protein VVD / 0.652
4f07 FADStyrene monooxygenase component 2 / 0.652
4xxg FADCholesterol oxidase 1.1.3.6 0.652
1mxt FAECholesterol oxidase 1.1.3.6 0.651
2iw5 FADLysine-specific histone demethylase 1A 1 0.651
2jkc FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.651
3bi2 FADPolyamine oxidase FMS1 / 0.651
4ynt FDAGlucose oxidase, putative / 0.651
3bgi SAHThiopurine S-methyltransferase 2.1.1.67 0.650
3lb8 FADPutidaredoxin reductase 1.18.1.5 0.650
4kuk RBFPutative blue-light photoreceptor / 0.650