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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3agl A03 cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.492
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.798
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.794
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.792
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.792
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.790
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.766
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.760
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.743
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.742
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.736
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.736
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.734
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.730
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.723
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
4ysj ADPCalmodulin-like domain protein kinase / 0.723
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.719
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.716
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.712
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.710
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.704
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.698
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.695
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.691
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.683
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.681
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.679
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.676
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.673
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.672
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
2vqd AP2Biotin carboxylase 6.3.4.14 0.670
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.670
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.667
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.667
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.665
4qny ANPMitogen activated protein kinase, putative / 0.665
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.664
4xlv ACPInsulin receptor 2.7.10.1 0.664
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.663
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.660
5ce3 ADPProtein kinase YopO / 0.660
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.658
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.658
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.658
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.656
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.656
4utd ACPAurora kinase A 2.7.11.1 0.655
2pui ADPMethylthioribose kinase 2.7.1.100 0.654
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.654
3gu8 3GUDeath-associated protein kinase 1 2.7.11.1 0.653
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.653
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.653
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.650
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.650