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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3aej AA5 Methionine gamma-lyase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3aej AA5Methionine gamma-lyase / 1.325
1arg PPDAspartate aminotransferase 2.6.1.1 0.736
4oma LCSMethionine gamma-lyase / 0.719
1ahg TYR_PLPAspartate aminotransferase 2.6.1.1 0.710
1cl2 PPGCystathionine beta-lyase MetC 4.4.1.8 0.706
2ycn P61Tyrosine phenol-lyase 4.1.99.2 0.704
4wxg 2BOSerine hydroxymethyltransferase / 0.704
1x28 PGUAspartate aminotransferase 2.6.1.1 0.695
1maq PGUAspartate aminotransferase, mitochondrial 2.6.1.1 0.691
1akb PPDAspartate aminotransferase, mitochondrial 2.6.1.1 0.685
4i1n FOLDihydrofolate reductase 1.5.1.3 0.681
1akc PPEAspartate aminotransferase, mitochondrial 2.6.1.1 0.680
3qpg 3QPAspartate aminotransferase 2.6.1.1 0.679
4dbc 3QPAspartate aminotransferase 2.6.1.1 0.679
3kkz SAMUncharacterized protein / 0.678
1dfo PLGSerine hydroxymethyltransferase 2.1.2.1 0.677
4x5g FOLDihydrofolate reductase 1.5.1.3 0.670
1toi HCIAspartate aminotransferase 2.6.1.1 0.665
4ge4 0KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial 2.6.1.39 0.660
1toj HCIAspartate aminotransferase 2.6.1.1 0.659
4kfj FOLDihydrofolate reductase 1.5.1.3 0.659
4w5k PLPAspartate aminotransferase, mitochondrial / 0.658
4bqw QNMEgl nine homolog 1 / 0.657
1arh PPDAspartate aminotransferase 2.6.1.1 0.655
1rc4 DDFDihydrofolate reductase 1.5.1.3 0.655
1rf7 DHFDihydrofolate reductase 1.5.1.3 0.655
2d0k FOLDihydrofolate reductase 1.5.1.3 0.653
4kjj FOLDihydrofolate reductase 1.5.1.3 0.653
1d3g BREDihydroorotate dehydrogenase (quinone), mitochondrial 1.3.5.2 0.652
4x5h FOLDihydrofolate reductase 1.5.1.3 0.651