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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ada NAD Subunit alpha of sarocosine oxidase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity
Align
3ada NADSubunit alpha of sarocosine oxidase / 1.216
3ad9 NADSubunit alpha of sarocosine oxidase / 1.156
3ict FADCoenzyme A disulfide reductase / 0.795
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.794
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.780
1grg FADGlutathione reductase, mitochondrial 1.8.1.7 0.779
1grh FADGlutathione reductase, mitochondrial 1.8.1.7 0.778
4jdr FADDihydrolipoyl dehydrogenase 1.8.1.4 0.778
2eq7 FADDihydrolipoyl dehydrogenase / 0.777
3t37 FADPyridoxine 4-oxidase / 0.767
2x8g FADThioredoxin glutathione reductase / 0.766
3djg FADGlutathione reductase, mitochondrial 1.8.1.7 0.765
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.764
4la1 FADThioredoxin glutathione reductase / 0.764
5fs9 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.764
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.763
3fbs FADOxidoreductase / 0.763
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.762
2x8h FADThioredoxin glutathione reductase / 0.762
4kpr FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.762
1gra FADGlutathione reductase, mitochondrial 1.8.1.7 0.761
1zk7 FADMercuric reductase 1.16.1.1 0.761
3djj FADGlutathione reductase, mitochondrial 1.8.1.7 0.759
1geu FADGlutathione reductase 1.8.1.7 0.758
4jn9 FADDepH / 0.758
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.757
2hqm FADGlutathione reductase 1.8.1.7 0.754
3dk8 FADGlutathione reductase, mitochondrial 1.8.1.7 0.754
1ges FADGlutathione reductase 1.8.1.7 0.751
1gal FADGlucose oxidase 1.1.3.4 0.750
1zx9 FADMercuric reductase 1.16.1.1 0.749
2f5z FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.749
1cjc FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.748
1e6e FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.746
3dgz FADThioredoxin reductase 2, mitochondrial 1.8.1.9 0.746
5j60 FADThioredoxin reductase / 0.744
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.742
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.739
4hb9 FADUncharacterized protein / 0.739
1d4c FADFumarate reductase flavoprotein subunit 1.3.5.4 0.738
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.738
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.738
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.737
3r9u FADThioredoxin reductase / 0.736
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.736
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.736
3f8r NAPNADH oxidase/thioredoxin reductase / 0.733
2q0k FADThioredoxin reductase 1.8.1.9 0.731
4ccq FADThioredoxin reductase / 0.731
1feb FADTrypanothione reductase 1.8.1.12 0.729
3nlc FADUncharacterized protein / 0.729
2gmh FADElectron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial 1.5.5.1 0.727
2gr0 FADFerredoxin reductase / 0.727
1gpe FADGlucose oxidase 1.1.3.4 0.725
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.724
1fec FADTrypanothione reductase 1.8.1.12 0.723
2eq8 FADDihydrolipoyl dehydrogenase / 0.723
2gh5 FADGlutathione reductase, mitochondrial 1.8.1.7 0.723
4lii FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.723
4emj FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.722
2eq6 FADDihydrolipoyl dehydrogenase / 0.720
3ish FADThioredoxin reductase 1.8.1.9 0.720
4usr FADMonooxygenase / 0.719
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.717
3cge FADCoenzyme A disulfide reductase / 0.717
4cbq FADThioredoxin reductase / 0.717
4tlx FDAKtzI / 0.716
1trb FADThioredoxin reductase 1.8.1.9 0.715
2tpr FADTrypanothione reductase 1.8.1.12 0.714
3q9t FAYUncharacterized protein / 0.714
3rnm FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.714
4tm1 FDAKtzI / 0.714
5buk FADFADH2-dependent halogenase / 0.714
2zbw FADFerredoxin--NADP reductase / 0.713
3cgc FADCoenzyme A disulfide reductase / 0.713
3cox FADCholesterol oxidase 1.1.3.6 0.713
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.712
3jsk AHZThiamine thiazole synthase / 0.712
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.711
4gcm FADThioredoxin reductase 1.8.1.9 0.711
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.711
2yvj FADFerredoxin reductase / 0.710
2v6o FADThioredoxin glutathione reductase / 0.709
4z24 FADPutative GMC-type oxidoreductase R135 1 0.709
1gv4 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.708
1h81 FADPolyamine oxidase 1.5.3.14 0.708
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.708
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.708
3k7m FAD6-hydroxy-L-nicotine oxidase / 0.708
4gut FADLysine-specific histone demethylase 1B 1 0.708
1djn ADPTrimethylamine dehydrogenase 1.5.8.2 0.707
1mo9 FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.707
2eq9 FADDihydrolipoyl dehydrogenase / 0.707
3qfb FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.707
4u2t FADCholesterol oxidase 1.1.3.6 0.707
3f8p NADNADH oxidase/thioredoxin reductase / 0.706
1ger FADGlutathione reductase 1.8.1.7 0.705
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.703
3lxd FADFAD-dependent pyridine nucleotide-disulfide oxidoreductase / 0.702
1cf3 FADGlucose oxidase 1.1.3.4 0.701
3ef6 FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.701
3gwf FADCyclohexanone monooxygenase / 0.701
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.700
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.700
3m0o FADMonomeric sarcosine oxidase 1.5.3.1 0.700
1m6i FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.699
4a99 FADTetX family tetracycline inactivation enzyme / 0.699
2j3n FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.698
3cgb FADCoenzyme A disulfide reductase / 0.698
3nn6 FB06-hydroxy-L-nicotine oxidase / 0.698
4a65 FADThioredoxin reductase / 0.697
4ccr FADThioredoxin reductase / 0.697
5fs6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.696
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.695
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.695
4jq9 FADDihydrolipoyl dehydrogenase / 0.695
1lqu FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.694
4dsg FADUncharacterized protein / 0.694
5cku FADL-ornithine N(5)-monooxygenase / 0.694
1gxf FADTrypanothione reductase 1.8.1.12 0.693
1tdf FADThioredoxin reductase 1.8.1.9 0.693
1zmc FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.693
2gew FADCholesterol oxidase 1.1.3.6 0.693
2tmd ADPTrimethylamine dehydrogenase 1.5.8.2 0.693
3b6d FAECholesterol oxidase 1.1.3.6 0.693
3gyi FADCholesterol oxidase 1.1.3.6 0.693
1ijh FADCholesterol oxidase 1.1.3.6 0.692
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.692
2yg4 FADPutrescine oxidase / 0.691
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.691
2jb1 FADL-amino acid oxidase / 0.690
4qi5 FADCellobiose dehydrogenase / 0.690
1z6l FADPolyamine oxidase FMS1 / 0.689
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.689
1djq ADPTrimethylamine dehydrogenase 1.5.8.2 0.688
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.688
2yg7 FADPutrescine oxidase / 0.687
3nta FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.687
1pdh FASp-hydroxybenzoate hydroxylase / 0.686
1nhq FADNADH peroxidase 1.11.1.1 0.685
3k30 ADPHistamine dehydrogenase / 0.685
1nhp FADNADH peroxidase 1.11.1.1 0.684
1ryi FADGlycine oxidase 1.4.3.19 0.684
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.684
4tm4 FDAKtzI / 0.683
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.682
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.682
5fs7 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.682
4up3 FADThioredoxin reductase / 0.681
3kpk FADSulfide-quinone reductase / 0.680
5fs8 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.680
5hhf FDAUDP-galactopyranose mutase / 0.680
2ar8 FADFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.679
4fk1 FADPutative thioredoxin reductase / 0.679
4z26 FADPutative GMC-type oxidoreductase R135 1 0.679
1mxt FAECholesterol oxidase 1.1.3.6 0.678
3cty FADProbable thioredoxin reductase / 0.678
4o5u FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.678
1n1p FADCholesterol oxidase 1.1.3.6 0.677
1n4u FAECholesterol oxidase 1.1.3.6 0.677
1n4v FADCholesterol oxidase 1.1.3.6 0.677
1n4w FADCholesterol oxidase 1.1.3.6 0.677
3cnj FADCholesterol oxidase 1.1.3.6 0.677
4a5l FADThioredoxin reductase / 0.677
4o5q FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.677
4rek FADCholesterol oxidase 1.1.3.6 0.677
4u2l SFDCholesterol oxidase 1.1.3.6 0.677
4u2s FDACholesterol oxidase 1.1.3.6 0.677
4xwr FADCholesterol oxidase 1.1.3.6 0.677
4xxg FADCholesterol oxidase 1.1.3.6 0.677
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.676
3rha FDAPutrescine oxidase / 0.676
3we0 FADLysine 2-monooxygenase / 0.675
4gus FADLysine-specific histone demethylase 1B 1 0.675
4hsu FADLysine-specific histone demethylase 1B 1 0.675
4j56 FADThioredoxin reductase 2 1.8.1.9 0.675
3cgd FADCoenzyme A disulfide reductase / 0.674
1bzl FADTrypanothione reductase 1.8.1.12 0.673
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.673
3tsc NADUncharacterized protein / 0.673
4b63 FADL-ornithine N(5)-monooxygenase / 0.673
4ech FADPolyamine oxidase FMS1 / 0.673
4fwe FADLysine-specific histone demethylase 1B 1 0.673
1cl0 FADThioredoxin reductase 1.8.1.9 0.672
3kkj FADRenalase / 0.672
4udr FAD5-(hydroxymethyl)furfural oxidase / 0.672
2r0c FADPutative FAD-monooxygenase / 0.671
4guu FA9Lysine-specific histone demethylase 1B 1 0.671
4qi7 FADCellobiose dehydrogenase / 0.671
4guv FADTetX family tetracycline inactivation enzyme / 0.670
3gyj FADCholesterol oxidase 1.1.3.6 0.669
3uov FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.669
4nzh FADL-ornithine N(5)-monooxygenase / 0.669
4qi4 FADCellobiose dehydrogenase / 0.669
4ysh FADGlycine oxidase / 0.669
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.668
2ym2 FADPhenylacetone monooxygenase 1.14.13.92 0.668
3ics FADCoenzyme A disulfide reductase / 0.668
1jki NAIInositol-3-phosphate synthase 5.5.1.4 0.667
1k0j FADp-hydroxybenzoate hydroxylase / 0.667
1vdc FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.667
3lsi FADPyranose 2-oxidase / 0.667
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.666
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.666
3t2k FADSulfide-quinone reductase / 0.666
4dsh FDAUncharacterized protein / 0.666
4tm3 FADKtzI / 0.666
3cnt FADPolyamine oxidase FMS1 / 0.665
3oz2 FADDigeranylgeranylglycerophospholipid reductase / 0.665
4gur FADLysine-specific histone demethylase 1B 1 0.665
4i58 FADCyclohexylamine Oxidase / 0.665
4wct FADFructosyl amine:oxygen oxidoreductase / 0.665
1cbo FADCholesterol oxidase 1.1.3.6 0.664
1y56 ATPUncharacterized protein / 0.664
2c4c FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 0.664
1c0l FADD-amino-acid oxidase 1.4.3.3 0.663
1f3p FADFerredoxin reductase / 0.663
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.663
1o94 ADPTrimethylamine dehydrogenase 1.5.8.2 0.663
3dgh FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.663
3gdp FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.663
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.662
2cul FADGidA-related protein / 0.662
2yg5 FADPutrescine oxidase / 0.662
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.662
3itj FADThioredoxin reductase 1 1.8.1.9 0.662
3uth FDAUDP-galactopyranose mutase / 0.662
1b4v FADCholesterol oxidase 1.1.3.6 0.661
4jnq FDAThioredoxin reductase / 0.661
1d7y FADFerredoxin reductase / 0.660
2x3n FADProbable FAD-dependent monooxygenase / 0.660
3utf FDAUDP-galactopyranose mutase / 0.660
4c3y FAD3-ketosteroid dehydrogenase / 0.660
4h4u FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.660
4u8n FDAUDP-galactopyranose mutase / 0.660
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.659
2yqu FADDihydrolipoyl dehydrogenase / 0.659
3sz0 FADSulfide-quinone reductase / 0.659
5eb5 FAD(R)-mandelonitrile lyase 1 4.1.2.10 0.659
2b9y FADPutative aminooxidase / 0.658
2qa1 FADPgaE / 0.658
2xvf FADPutative flavin-containing monooxygenase / 0.658
3lov FADProtoporphyrinogen oxidase / 0.658
4b68 FADL-ornithine N(5)-monooxygenase / 0.658
3qvp FADGlucose oxidase 1.1.3.4 0.657
3ukl FADUDP-galactopyranose mutase / 0.657
4bk2 FADProbable salicylate monooxygenase / 0.657
4c3x FAD3-ketosteroid dehydrogenase / 0.657
4ynt FDAGlucose oxidase, putative / 0.657
3icr FADCoenzyme A disulfide reductase / 0.656
4fwf FADLysine-specific histone demethylase 1B 1 0.656
4nte FADDepH / 0.656
1b8s FADCholesterol oxidase 1.1.3.6 0.655
1k0l FADp-hydroxybenzoate hydroxylase / 0.655
2gqf FADUncharacterized protein HI_0933 / 0.655
3m12 FADMonomeric sarcosine oxidase 1.5.3.1 0.655
1ojt FADDihydrolipoyl dehydrogenase / 0.654
2dw4 FADLysine-specific histone demethylase 1A 1 0.654
2whd FADThioredoxin reductase / 0.653
3ute FADUDP-galactopyranose mutase / 0.653
4eqw FADCoenzyme A disulfide reductase / 0.653
2bab FADPutative aminooxidase / 0.651
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.651
2b9w FADPutative aminooxidase / 0.650
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.650
4bur FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.650
4gdp FADPolyamine oxidase FMS1 / 0.650