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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3a8w ATP Protein kinase C iota type 2.7.11.13

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3a8w ATPProtein kinase C iota type 2.7.11.13 0.916
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.769
3orp AGSSerine/threonine protein kinase / 0.750
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.722
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.718
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.717
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.715
3ork AGSSerine/threonine protein kinase / 0.713
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.700
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.695
3orl AGSSerine/threonine protein kinase / 0.695
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.694
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.693
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.692
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.689
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.684
2acx ANPG protein-coupled receptor kinase 6 2.7.11.16 0.684
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.684
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
3orm AGSSerine/threonine protein kinase / 0.675
3t8o ATPRhodopsin kinase / 0.675
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.675
4qml ANPSerine/threonine-protein kinase 24 2.7.11.1 0.675
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.672
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.672
2pul ACPMethylthioribose kinase 2.7.1.100 0.672
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
5dnr ATPAurora kinase A 2.7.11.1 0.671
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.670
3lct ADPALK tyrosine kinase receptor 2.7.10.1 0.669
3ort AGSSerine/threonine protein kinase / 0.667
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.667
4c3r ACPAurora kinase A 2.7.11.1 0.667
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.666
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.666
2dwb ANPAurora kinase A 2.7.11.1 0.666
3m0e ATPTranscriptional regulator (NtrC family) / 0.665
5i4n ATPTyrosine-protein kinase JAK2 / 0.665
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.664
2olc ADPMethylthioribose kinase 2.7.1.100 0.664
3c4w ATPRhodopsin kinase / 0.663
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.662
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.662
5dn3 ATPAurora kinase A 2.7.11.1 0.662
2pui ADPMethylthioribose kinase 2.7.1.100 0.661
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.661
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.660
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.659
3c4z ADPRhodopsin kinase / 0.659
3llt ANPProtein serine/threonine kinase-1 / 0.659
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.658
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.658
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.656
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.656
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.655
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.655
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.654
2pup ADPMethylthioribose kinase 2.7.1.100 0.653
4ceg ADPAurora kinase A 2.7.11.1 0.653
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.652
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.650