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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zm4 KSM Tyrosine-protein kinase Lck 2.7.10.2

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zm4 KSMTyrosine-protein kinase Lck 2.7.10.2 1.050
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
2zyb KSLTyrosine-protein kinase Lck 2.7.10.2 0.731
2zva 1N1Tyrosine-protein kinase Lyn 2.7.10.2 0.725
2y6o 1N1Ephrin type-A receptor 4 2.7.10.1 0.684
2gqg 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.680
3oct 1N1Tyrosine-protein kinase BTK 2.7.10.2 0.667
3qlg 1N1Proto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.667
4xey 1N1Tyrosine-protein kinase ABL1 2.7.10.2 0.663
4e5f 0N7Polymerase acidic protein / 0.660
4ftm 1HKSerine/threonine-protein kinase Chk1 2.7.11.1 0.658