Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2zhf 49U Prothrombin 3.4.21.5

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2zhf 49UProthrombin 3.4.21.5 0.977
2zi2 24UProthrombin 3.4.21.5 0.962
2zfq 45UProthrombin 3.4.21.5 0.941
2zhq 27UProthrombin 3.4.21.5 0.934
2zg0 50UProthrombin 3.4.21.5 0.920
2ziq 26UProthrombin 3.4.21.5 0.900
2zfr 46UProthrombin 3.4.21.5 0.886
2zgx 29UProthrombin 3.4.21.5 0.886
1k22 MELProthrombin 3.4.21.5 0.881
4bah MELProthrombin 3.4.21.5 0.881
4bam MM9Prothrombin 3.4.21.5 0.881
2zda 32UProthrombin 3.4.21.5 0.880
4ban M6SProthrombin 3.4.21.5 0.879
2zhe 13UProthrombin 3.4.21.5 0.862
4bao MVFProthrombin 3.4.21.5 0.862
4bak M67Prothrombin 3.4.21.5 0.860
3biv 11UProthrombin 3.4.21.5 0.859
4baq M4ZProthrombin 3.4.21.5 0.855
2gde SN3Prothrombin 3.4.21.5 0.839
1riw OSCProthrombin 3.4.21.5 0.838
2znk 31UProthrombin 3.4.21.5 0.836
3utu 1TSProthrombin 3.4.21.5 0.832
2v3h I25Prothrombin 3.4.21.5 0.828
1ypm RA4Prothrombin 3.4.21.5 0.816
1ypl RA8Prothrombin 3.4.21.5 0.805
2bdy UNBProthrombin 3.4.21.5 0.802
1k21 IGNProthrombin 3.4.21.5 0.781
2zhw 12UProthrombin 3.4.21.5 0.776
1c4v IH2Prothrombin 3.4.21.5 0.772
1lpk CBBCoagulation factor X 3.4.21.6 0.763
1ae8 AZLProthrombin 3.4.21.5 0.758
2zdv 37UProthrombin 3.4.21.5 0.754
4ayy 9MXProthrombin 3.4.21.5 0.752
4ax9 N5NProthrombin 3.4.21.5 0.750
1ype UIPProthrombin 3.4.21.5 0.749
1ypk CCRProthrombin 3.4.21.5 0.749
4e7r 0NWProthrombin 3.4.21.5 0.747
3hat GLY_VAL_ARG_RNGProthrombin 3.4.21.5 0.746
1g7u PEP2-dehydro-3-deoxyphosphooctonate aldolase 2.5.1.55 0.744
4e5i 0N9Polymerase acidic protein / 0.744
5cmx 0G6Prothrombin 3.4.21.5 0.744
1c5n ESIProthrombin 3.4.21.5 0.740
4ayv 9MQProthrombin 3.4.21.5 0.739
2anm CDOProthrombin 3.4.21.5 0.738
3plp BBACationic trypsin 3.4.21.4 0.737
1afe ALZProthrombin 3.4.21.5 0.729
1c4u IH1Prothrombin 3.4.21.5 0.729
3qto 10PProthrombin 3.4.21.5 0.723
4az2 9MUProthrombin 3.4.21.5 0.723
1nzq 162Prothrombin 3.4.21.5 0.722
2zp0 PI0Coagulation factor VII 3.4.21.21 0.721
1vzq SHYProthrombin 3.4.21.5 0.720
1wqv PSMCoagulation factor VII 3.4.21.21 0.720
1ypj UIBProthrombin 3.4.21.5 0.718
3biu 10UProthrombin 3.4.21.5 0.715
1d4p BPPProthrombin 3.4.21.5 0.713
2zff 53UProthrombin 3.4.21.5 0.712
3qwc 98PProthrombin 3.4.21.5 0.712
7kme ACE_0BN_CHG_PRRProthrombin 3.4.21.5 0.712
1o0d 163Prothrombin 3.4.21.5 0.709
1uvs I11Prothrombin 3.4.21.5 0.709
3p17 99PProthrombin 3.4.21.5 0.708
2pks G44Prothrombin 3.4.21.5 0.707
2zf0 51UProthrombin 3.4.21.5 0.706
3dhk 23UProthrombin 3.4.21.5 0.705
1zsk 421Coagulation factor XI 3.4.21.27 0.703
1wtg 3BPCoagulation factor VII 3.4.21.21 0.702
3v0x ANHCationic trypsin 3.4.21.4 0.701
1ta2 176Prothrombin 3.4.21.5 0.700
2cn0 F25Prothrombin 3.4.21.5 0.699
3dux 64UProthrombin 3.4.21.5 0.698
3qdz PRO_ALA_PRO_ARGProthrombin 3.4.21.5 0.692
1d9i 00PProthrombin 3.4.21.5 0.691
1ypg UIRProthrombin 3.4.21.5 0.690
1c1u BAIProthrombin 3.4.21.5 0.688
2zc9 22UProthrombin 3.4.21.5 0.687
1vja 7INUrokinase-type plasminogen activator 3.4.21.73 0.686
3f68 91UProthrombin 3.4.21.5 0.684
3qtv 06PProthrombin 3.4.21.5 0.682
3eq0 2TSProthrombin 3.4.21.5 0.680
1nt1 T76Prothrombin 3.4.21.5 0.679
1ta6 177Prothrombin 3.4.21.5 0.679
2v3o I26Prothrombin 3.4.21.5 0.679
1xm1 GAHProthrombin 3.4.21.5 0.678
2zgb 21UProthrombin 3.4.21.5 0.676
2a2x NA9Prothrombin 3.4.21.5 0.674
2cf8 ESHProthrombin 3.4.21.5 0.673
2zfp 19UProthrombin 3.4.21.5 0.673
1f92 UKPUrokinase-type plasminogen activator 3.4.21.73 0.670
1sl3 170Prothrombin 3.4.21.5 0.667
4jpe 1M7Beta-secretase 1 3.4.23.46 0.666
4joo 1M4Beta-secretase 1 3.4.23.46 0.662
1mue CDDProthrombin 3.4.21.5 0.661
4e5f 0N7Polymerase acidic protein / 0.660
1nm6 L86Prothrombin 3.4.21.5 0.658
3c1k T15Prothrombin 3.4.21.5 0.657
1owe 675Urokinase-type plasminogen activator 3.4.21.73 0.656
1c1w BAHProthrombin 3.4.21.5 0.653
1ny2 ARG_PRO_PRO_GLYProthrombin 3.4.21.5 0.653
4fub 4UPUrokinase-type plasminogen activator 3.4.21.73 0.653
1owi 426Urokinase-type plasminogen activator 3.4.21.73 0.652